KEGG   DRUG: D09668Help
Entry
D09668                      Drug                                   

Name
Sifalimumab (USAN/INN)
Formula
C6396H9918N1714O2006S42
Exact mass
144177.5032
Mol weight
144266.1963
Sequence
(Heavy chain) QVQLVQSGAE VKKPGASVKV SCKASGYTFT SYSISWVRQA
PGQGLEWMGW ISVYNGNTNY AQKFQGRVTM TTDTSTSTAY LELRSLRSDD TAVYYCARDP
IAAGYWGQGT LVTVSSASTK GPSVFPLAPS SKSTSGGTAA LGCLVKDYFP EPVTVSWNSG
ALTSGVHTFP AVLQSSGLYS LSSVVTVPSS SLGTQTYICN VNHKPSNTKV DKKVEPKSCD
KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG
VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG
QPREPQVYTL PPSREEMTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD
GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGK
(Disulfide bridge: 22-96; 143-199; 260-320; 366-424, Dimer: 225; 228)
(Light chain) EIVLTQSPGT LSLSPGERAT LSCRASQSVS STYLAWYQQK
PGQAPRLLIY GASSRATGIP DRFSGSGSGT DFTLTISRLE PEDFAVYYCQ QYGSSPRTFG
QGTKVEIKRT VAAPSVFIFP PSDEQLKSGT ASVVCLLNNF YPREAKVQWK VDNALQSGNS
QESVTEQDSK DSTYSLSSTL TLSKADYEKH KVYACEVTHQ GLSSPVTKSF NRGEC
(Disulfide bridge: 23-89; 135-195; H219-L215)
  Type
Peptide
Activity
Treatment of SLE, dermatomyositis, and polymyositis
Comment
Monoclonal antibody
Target
interferon alpha [HSA:3439 3440 3441 3442 3443 3444 3445 3446 3447 3448 3449 3451 3452] [KO:K05414]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04140  Regulation of autophagy  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines
  Class II cytokines
   interferon alpha
    Sifalimumab
     D09668  Sifalimumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
1006877-41-3
PubChem: 

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