KEGG   DRUG: SiltuximabHelp
Entry
D09669                      Drug                                   

Name
Siltuximab (USAN/INN);
Sylvant (TN)
Product
Formula
C6450H9932N1688O2016S50
Exact mass
144891.2586
Mol weight
144981.2251
Sequence
(Heavy chain) EVQLVESGGK LLKPGGSLKL SCAASGFTFS SFAMSWFRQS
PEKRLEWVAE ISSGGSYTYY PDTVTGRFTI SRDNAKNTLY LEMSSLRSED TAMYYCARGL
WGYYALDYWG QGTSVTVSSA STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW
NSGALTSGVH TFPAVLQSSG LYSLSSVVTV PSSSLGTQTY ICNVNHKPSN TKVDKKVEPK
SCDKTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY
VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK
AKGQPREPQV YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL
DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
(Disulfide bridge: 22-96; 146-202; 263-323; 369-427, Dimer: 228; 231)
(Light chain) QIVLIQSPAI MSASPGEKVT MTCSASSSVS YMYWYQQKPG
SSPRLLIYDT SNLASGVPVR FSGSGSGTSY SLTISRMEAE DAATYYCQQW SGYPYTFGGG
TKLEIKRTVA APSVFIFPPS DEQLKSGTAS VVCLLNNFYP REAKVQWKVD NALQSGNSQE
SVTEQDSKDS TYSLSSTLTL SKADYEKHKV YACEVTHQGL SSPVTKSFNR GEC
(Disulfide bridge: 23-87; 133-193; H222-L213)
  Type
Peptide
Class
Other
 DG02019  Interleukin inhibitor
Remark
ATC code: 
Activity
Immunomodulator, Anti-IL-6 antibody
  Disease
Castleman's disease [DS:H01479]
Comment
Monoclonal antibody
Target
IL6 [HSA:3569] [KO:K05405]
  Pathway
Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AC Interleukin inhibitors
     L04AC11 Siltuximab
      D09669  Siltuximab (USAN/INN)
USP drug classification [BR:br08302]
 Immunological Agents
  Immunomodulators
   Siltuximab
    D09669  Siltuximab (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Cytokines
  Class I cytokines
   interleukin 6
    Siltuximab
     D09669  Siltuximab (USAN/INN)
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D09669
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09669
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09669
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D09669
BRITE hierarchy
Other DBs
CAS: 
541502-14-1
PubChem: 

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