KEGG   DRUG: D09669Help
Entry
D09669                      Drug                                   

Name
Siltuximab (USAN/INN)
Product
Formula
C6450H9932N1688O2016S50
Exact mass
144891.2586
Mol weight
144981.2251
Sequence
(Heavy chain) EVQLVESGGK LLKPGGSLKL SCAASGFTFS SFAMSWFRQS
PEKRLEWVAE ISSGGSYTYY PDTVTGRFTI SRDNAKNTLY LEMSSLRSED TAMYYCARGL
WGYYALDYWG QGTSVTVSSA STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW
NSGALTSGVH TFPAVLQSSG LYSLSSVVTV PSSSLGTQTY ICNVNHKPSN TKVDKKVEPK
SCDKTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY
VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK
AKGQPREPQV YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL
DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
(Disulfide bridge: 22-96; 146-202; 263-323; 369-427, Dimer: 228; 231)
(Light chain) QIVLIQSPAI MSASPGEKVT MTCSASSSVS YMYWYQQKPG
SSPRLLIYDT SNLASGVPVR FSGSGSGTSY SLTISRMEAE DAATYYCQQW SGYPYTFGGG
TKLEIKRTVA APSVFIFPPS DEQLKSGTAS VVCLLNNFYP REAKVQWKVD NALQSGNSQE
SVTEQDSKDS TYSLSSTLTL SKADYEKHKV YACEVTHQGL SSPVTKSFNR GEC
(Disulfide bridge: 23-87; 133-193; H222-L213)
  Type
Peptide
Comment
Monoclonal antibody
Target
IL-6 [HSA:3569] [KO:K05405]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  Jak-STAT signaling pathway  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines
  Class I cytokines
   IL-6
    Siltuximab
     D09669  Siltuximab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
541502-14-1
PubChem: 

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