KEGG   DRUG: D09670Help
Entry
D09670                      Drug                                   

Name
Sotatercept (USAN/INN)
Formula
C3448H5264N920O1058S42
Exact mass
77829.4657
Mol weight
77878.949
Sequence
ILGRSETQEC LFFNANWEKD RTNQTGVEPC YGDKDKRRHC FATWKNISGS IEIVKQGCWL
DDINCYDRTD CVEKKDSPEV YFCCCEGNMC NEKFSYFPEM EVTQPTSNPV TPKPPTGGGT
HTCPPCPAPE LLGGPSVFLF PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE
VHNAKTKPRE EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPVPIE KTISKAKGQP
REPQVYTLPP SREEMTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS
FFLYSKLTVD KSRWQQGNVF SCSVMHEALH NHYTQKSLSL SPGK
(Disulfide bridge: 10-40; 30-58; 65-84; 71-83; 85-90; 158-218; 264-322, Dimer: 123; 126)
  Type
Peptide
Activity
Red cell maturation agent for the treatment of anemia, and bone anabolic agent for the treatment of cancer-related bone loss
Comment
Fusion protein (extracellular domain of the activin receptor 2A and Fc of IgG1)
Target
activin receptor type-2A (ACVR2A) [HSA:92] [KO:K04670]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04350  TGF-beta signaling pathway  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  TGF-beta receptors
   ACVR2A
    Sotatercept
     D09670  Sotatercept (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
1001080-50-7
PubChem: 

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