KEGG   DRUG: D09704Help
Entry
D09704                      Drug                                   

Name
Atacicept (USAN/INN)
Formula
C3104H4788N856O950S44
Exact mass
70662.0376
Mol weight
70707.2547
Sequence
AMRSCPEEQY WDPLLGTCMS CKTICNHQSQ RTCAAFCRSL SCRKEQGKFY DHLLRDCISC
ASICGQHPKQ CAYFCENKLR SEPKSSDKTH TCPPCPAPEA EGAPSVFLFP PKPKDTLMIS
RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE QYNSTYRVVS VLTVLHQDWL
NGKEYKCKVS NKALPSSIEK TISKAKGQPR EPQVYTLPPS RDELTKNQVS LTCLVKGFYP
SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSKLTVDK SRWQQGNVFS CSVMHEALHN
HYTQKSLSLS PGK
(Disulfide bridge: 5-18; 21-33; 25-37; 42-57; 60-71; 64-75; 127-187; 233-291, Dimer: 92; 95)
  Type
Peptide
Activity
Treatment of autoimmune disease
Comment
fusion protein (TACI [HSA:23495] [KO:K05150] - Ig)
Target
APRIL (TNFSF13) / BAFF (TNFSF13B) [HSA:8741 10673] [KO:K05475 K05476]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa05323  Rheumatoid arthritis  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines
  TNF family
   APRIL
    Atacicept
     D09704  Atacicept (USAN/INN)
   BAFF
    Atacicept
     D09704  Atacicept (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
845264-92-8
PubChem: 

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