KEGG   DRUG: D09727Help
Entry
D09727                      Drug                                   
Name
Insulin degludec (genetical recombination) (JAN);
Insulin degludec (USAN/INN);
Tresiba (TN)
Formula
C274H411N65O81S6
Exact mass
6099.8364
Mol weight
6103.972
Sequence
(A chain) Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala
Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys
(Amide bridge: 29-C)
(B chain) Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr
Gln Leu Glu Asn Tyr Cys Asn
(Disulfide bridge: 6-11; A7-B7; A19-B20)
(C chain)
  Type
Peptide
Activity
Treatment of diabetes [DS:H00408 H00409]
Target
insulin receptor agonist [HSA:3643] [KO:K04527]
  Pathway
hsa04520  Adherens junction
hsa04910  Insulin signaling pathway
hsa04930  Type II diabetes mellitus
hsa04960  Aldosterone-regulated sodium reabsorption  
 
Interaction
Drug interaction
Structure map
Antidiabetics
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class II (Insulin receptor family)
    insulin receptor [HSA:3643] [KO:K04527]
     Insulin degludec
      D09727  Insulin degludec (genetical recombination) (JAN); Insulin degludec (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
844439-96-9
PubChem: 

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