KEGG   DRUG: Insulin degludecHelp
Entry
D09727                      Drug                                   

Name
Insulin degludec (USAN/INN);
Insulin degludec (genetical recombination) (JAN);
Tresiba (TN)
Product
Formula
C274H411N65O81S6
Exact mass
6099.8364
Mol weight
6103.972
Sequence
(A chain) Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala
Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys
(Amide bridge: 29-C)
(B chain) Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr
Gln Leu Glu Asn Tyr Cys Asn
(Disulfide bridge: 6-11; A7-B7; A19-B20)
(C chain)
  Type
Peptide
Class
Antidiabetic agent
 DG01636  Insulin and analogue
  DG01801  Insulin analogue
   DG01797  Insulin analogue, long-acting
Cyp inducer
 DG01637  CYP1A2 inducer
Remark
Therapeutic category: 
ATC code: 
Efficacy
Antidiabetic, Insulin receptor agonist
Comment
Insulin analog
Treatment of diabetes
Target
INSR (CD220) [HSA:3643] [KO:K04527]
  Pathway
Adherens junction
Insulin signaling pathway
Type II diabetes mellitus
Aldosterone-regulated sodium reabsorption
Interaction
Drug interaction
Structure map
Antidiabetics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10A INSULINS AND ANALOGUES
    A10AE Insulins and analogues for injection, long-acting
     A10AE06 Insulin degludec
      D09727  Insulin degludec (USAN/INN)
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Insulins
   Insulin Degludec
    D09727  Insulin degludec (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2492  Pancreatic hormones
     D09727  Insulin degludec (USAN/INN); Insulin degludec (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class II (Insulin receptor family)
    insulin receptor
     Insulin degludec
      D09727  Insulin degludec (USAN/INN)
Antidiabetics [br08361.html]
 D09727
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D09727
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09727
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D09727
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09727
BRITE hierarchy
Other DBs
CAS: 
844439-96-9
PubChem: 

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