| Entry |
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| Name |
Teneligliptin hydrobromide hydrate (JAN) |
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| Formula |
(C22H30N6OS)2. 5HBr. xH2O
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| Structure |
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| Class |
|
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| Remark |
| Therapeutic category: | 3969 |
| Product (DG01283): | D09756<JP> |
| Product (mixture): | D10897<JP> |
|
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| Efficacy |
Antidiabetic, Dipeptidyl peptidase-4 (DPP-4) inhibitor |
|---|
| Disease |
Type 2 diabetes mellitus [DS: H00409] |
|---|
| Target |
|
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| Pathway |
| hsa04974 | Protein digestion and absorption |
|
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| Metabolism |
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| Interaction |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A10 DRUGS USED IN DIABETES
A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
A10BH Dipeptidyl peptidase 4 (DPP-4) inhibitors
A10BH08 Teneligliptin
D09756 Teneligliptin hydrobromide hydrate (JAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
3 Agents affecting metabolism
39 Other agents affecting metabolism
396 Antidiabetic agents
3969 Others
D09756 Teneligliptin hydrobromide hydrate (JAN)
Drug groups [BR:br08330]
Antidiabetic agent
DG02044 Hypoglycemic agent
DG01601 DPP-4 inhibitor
DG01283 Teneligliptin
D09756 Teneligliptin hydrobromide hydrate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01283 Teneligliptin
D09756 Teneligliptin hydrobromide hydrate
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG01283 Teneligliptin
D09756 Teneligliptin hydrobromide hydrate
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
DG01283 Teneligliptin
D09756 Teneligliptin hydrobromide hydrate
DG02951 FMO inhibitor
DG01283 Teneligliptin
D09756 Teneligliptin hydrobromide hydrate
Unclassified
DG03306 FMO substrate
DG03191 FMO1 substrate
DG01283 Teneligliptin
D09756 Teneligliptin hydrobromide hydrate
DG02950 FMO3 substrate
DG01283 Teneligliptin
D09756 Teneligliptin hydrobromide hydrate
Drug classes [BR:br08332]
Antidiabetic agent
DG01601 DPP-4 inhibitor
D09756 Teneligliptin hydrobromide hydrate
DG02044 Hypoglycemic agent
D09756 Teneligliptin hydrobromide hydrate
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
Peptidyl-peptidases
DPP4 (CD26)
D09756 Teneligliptin hydrobromide hydrate (JAN) <JP>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D09756
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D09756
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D09756
Drug groups [BR:br08330]
Antidiabetic agent
DG02044 Hypoglycemic agent
DG01601 DPP-4 inhibitor
DG01283 Teneligliptin
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01283 Teneligliptin
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG01283 Teneligliptin
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
DG01283 Teneligliptin
DG02951 FMO inhibitor
DG01283 Teneligliptin
Unclassified
DG03306 FMO substrate
DG03191 FMO1 substrate
DG01283 Teneligliptin
DG02950 FMO3 substrate
DG01283 Teneligliptin
|
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| Other DBs |
|
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| KCF data |
ATOM 66
1 N1x N 24.6400 -14.0000
2 C1x C 23.2400 -14.0000
3 C1y C 22.8200 -15.3300
4 C1x C 23.9400 -16.1700
5 C1y C 25.0600 -15.3300
6 C5a C 26.2500 -16.0300
7 N1y N 27.4400 -15.3300
8 C1x C 29.2600 -14.0000
9 C1x C 27.8600 -14.0000
10 C1x C 28.5600 -16.1700
11 S2x S 29.6800 -15.3300
12 N1y N 21.6300 -16.0300
13 C1x C 20.4400 -15.3300
14 C1x C 19.1800 -16.0300
15 N1y N 19.1800 -17.4300
16 C1x C 20.3700 -18.1300
17 C1x C 21.6300 -17.4300
18 C8y C 17.9900 -18.1300
19 C8y C 16.1700 -19.4600
20 C8x C 17.5700 -19.4600
21 N4y N 16.8700 -17.2900
22 N5x N 15.7500 -18.1300
23 C8y C 16.8700 -15.8900
24 C8x C 18.0600 -15.1900
25 C8x C 18.0600 -13.7900
26 C8x C 16.8700 -13.0900
27 C8x C 15.6800 -13.7900
28 C8x C 15.6800 -15.1900
29 C1a C 15.3300 -20.5800
30 O5a O 26.2500 -17.4300
31 X Br 34.0200 -14.3500
32 O0 O 34.5800 -17.0100
33 N1x N 24.6400 -14.0000
34 C1x C 23.2400 -14.0000
35 C1y C 22.8200 -15.3300
36 C1x C 23.9400 -16.1700
37 C1y C 25.0600 -15.3300
38 C5a C 26.2500 -16.0300
39 N1y N 27.4400 -15.3300
40 C1x C 27.8600 -14.0000
41 C1x C 29.2600 -14.0000
42 S2x S 29.6800 -15.3300
43 C1x C 28.5600 -16.1700
44 O5a O 26.2500 -17.4300
45 N1y N 21.6300 -16.0300
46 C1x C 20.4400 -15.3300
47 C1x C 19.1800 -16.0300
48 N1y N 19.1800 -17.4300
49 C1x C 20.3700 -18.1300
50 C1x C 21.6300 -17.4300
51 C8y C 17.9900 -18.1300
52 C8x C 17.5700 -19.4600
53 C8y C 16.1700 -19.4600
54 N5x N 15.7500 -18.1300
55 N4y N 16.8700 -17.2900
56 C8y C 16.8700 -15.8900
57 C8x C 18.0600 -15.1900
58 C8x C 18.0600 -13.7900
59 C8x C 16.8700 -13.0900
60 C8x C 15.6800 -13.7900
61 C8x C 15.6800 -15.1900
62 C1a C 15.3300 -20.5800
63 X Br 34.0200 -14.3500
64 X Br 34.0200 -14.3500
65 X Br 34.0200 -14.3500
66 X Br 34.0200 -14.3500
BOND 68
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 1 5 1
6 5 6 1 #Down
7 6 7 1
8 8 9 1
9 9 7 1
10 7 10 1
11 10 11 1
12 8 11 1
13 3 12 1 #Down
14 12 13 1
15 13 14 1
16 14 15 1
17 15 16 1
18 16 17 1
19 12 17 1
20 15 18 1
21 19 20 1
22 20 18 2
23 18 21 1
24 21 22 1
25 19 22 2
26 21 23 1
27 23 24 2
28 24 25 1
29 25 26 2
30 26 27 1
31 27 28 2
32 23 28 1
33 19 29 1
34 6 30 2
35 33 34 1
36 34 35 1
37 35 36 1
38 36 37 1
39 33 37 1
40 37 38 1 #Down
41 38 39 1
42 41 40 1
43 40 39 1
44 39 43 1
45 43 42 1
46 41 42 1
47 35 45 1 #Down
48 45 46 1
49 46 47 1
50 47 48 1
51 48 49 1
52 49 50 1
53 45 50 1
54 48 51 1
55 53 52 1
56 52 51 2
57 51 55 1
58 55 54 1
59 53 54 2
60 55 56 1
61 56 57 2
62 57 58 1
63 58 59 2
64 59 60 1
65 60 61 2
66 56 61 1
67 53 62 1
68 38 44 2
BRACKET 1 13.5800 -21.3500 13.5800 -12.6000
1 30.1000 -12.6000 30.1000 -21.3500
1 2
ORIGINAL 1 1 2 3 4 5 6 7 9 8 11 10 30 12 13 14 15
1 16 17 18 20 19 22 21 23 24 25 26 27 28 29
REPEAT 1 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48
1 49 50 51 52 53 54 55 56 57 58 59 60 61 62
2 32.6900 -14.9800 32.6900 -13.7200
2 35.1400 -13.7200 35.1400 -14.9800
2 5
ORIGINAL 2 31
REPEAT 2 63 64 65 66
3 32.8300 -17.7100 32.8300 -16.3800
3 35.0700 -16.3800 35.0700 -17.7100
3 x
ORIGINAL 3 32
REPEAT 3
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