KEGG   DRUG: MogamulizumabHelp
Entry
D09761                      Drug                                   

Name
Mogamulizumab (USAN);
Mogamulizumab (genetical recombination) (JAN);
KW-0761;
Poteligeo (TN)
Formula
C6520H10072N1736O2020S42
Exact mass
146352.7047
Mol weight
146442.8849
Sequence
(Heavy chain)
EVQLVESGGD LVQPGRSLRL SCAASGFIFS NYGMSWVRQA PGKGLEWVAT ISSASTYSYY
PDSVKGRFTI SRDNAKNSLY LQMNSLRVED TALYYCGRHS DGNFAFGYWG QGTLVTVSSA
STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW NSGALTSGVH TFPAVLQSSG
LYSLSSVVTV PSSSLGTQTY ICNVNHKPSN TKVDKKVEPK SCDKTHTCPP CPAPELLGGP
SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS
TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSRDEL
TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ
QGNVFSCSVM HEALHNHYTQ KSLSLSPGK (dimer)
(Light chain)
DVLMTQSPLS LPVTPGEPAS ISCRSSRNIV HINGDTYLEW YLQKPGQSPQ LLIYKVSNRF
SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCFQGSLLP WTFGQGTKVE IKRTVAAPSV
FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ SGNSQESVTE QDSKDSTYSL
SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC (dimer)
(disulfide bridge: H22-H96; H146-H202; H222-L219; H228-H'228; H231-H'231; H263-H323; H369-H427; H'B22-H'96; H'146-H'202; H'222-L'219; H'263-H'323; H'369-H'427; L23-L93; L139-L199; L'23-L'93; L'139-L'199)
  Type
Peptide
Remark
Therapeutic category: 
ATC code: 
Activity
Antineoplastic
Comment
Monoclonal antibody
Target
CCR4 (CD194) [HSA:1233] [KO:K04179]
  Pathway
Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XC Monoclonal antibodies
     L01XC25 Mogamulizumab
      D09761  Mogamulizumab (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D09761  Mogamulizumab (USAN); Mogamulizumab (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Chemokine receptors
   chemokine receptor 4 (CCR4)
    Mogamulizumab
     D09761  Mogamulizumab (USAN)
Antineoplastics [br08340.html]
 D09761
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D09761
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09761
BRITE hierarchy
Other DBs
CAS: 
1159266-37-1
PubChem: 

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