KEGG   DRUG: D09761Help
Entry
D09761                      Drug                                   

Name
Mogamulizumab (genetical recombination) (JAN);
Mogamulizumab (USAN);
KW-0761;
Poteligeo (TN)
Formula
C6520H10072N1736O2020S42
Exact mass
146352.7047
Mol weight
146442.8849
Sequence
(Heavy chain)
EVQLVESGGD LVQPGRSLRL SCAASGFIFS NYGMSWVRQA PGKGLEWVAT ISSASTYSYY
PDSVKGRFTI SRDNAKNSLY LQMNSLRVED TALYYCGRHS DGNFAFGYWG QGTLVTVSSA
STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW NSGALTSGVH TFPAVLQSSG
LYSLSSVVTV PSSSLGTQTY ICNVNHKPSN TKVDKKVEPK SCDKTHTCPP CPAPELLGGP
SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS
TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSRDEL
TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ
QGNVFSCSVM HEALHNHYTQ KSLSLSPGK (dimer)
(Light chain)
DVLMTQSPLS LPVTPGEPAS ISCRSSRNIV HINGDTYLEW YLQKPGQSPQ LLIYKVSNRF
SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCFQGSLLP WTFGQGTKVE IKRTVAAPSV
FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ SGNSQESVTE QDSKDSTYSL
SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC (dimer)
(disulfide bridge: H22-H96; H146-H202; H222-L219; H228-H'228; H231-H'231; H263-H323; H369-H427; H'B22-H'96; H'146-H'202; H'222-L'219; H'263-H'323; H'369-H'427; L23-L93; L139-L199; L'23-L'93; L'139-L'199)
  Type
Peptide
Activity
Antineoplastic [DS:H00009]
Remark
Therapeutic category: 
Comment
anti-CCR4 antibody
Target
C-C chemokine receptor type 4 (CCR4) [HSA:1233] [KO:K04179]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04062  Chemokine signaling pathway  
 
Interaction
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D09761  Mogamulizumab (genetical recombination) (JAN); Mogamulizumab (USAN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Chemokine receptors
   chemokine receptor 4 (CCR4) [HSA:1233] [KO:K04179]
    Mogamulizumab
     D09761  Mogamulizumab (genetical recombination) (JAN); Mogamulizumab (USAN)
BRITE hierarchy
Other DBs
CAS: 
1159266-37-1
PubChem: 

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