KEGG   DRUG: Norepinephrine hydrochlorideHelp
Entry
D09794                      Drug                                   

Name
Norepinephrine hydrochloride (JAN);
(+/-)-Noradrenaline hydrochloride
Formula
C8H11NO3. HCl
Exact mass
205.0506
Mol weight
205.6388
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01699  Catecholamine cardiotonic
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01448  alpha1-Adrenergic receptor agonist
   DG01449  alpha2-Adrenergic receptor agonist
  DG01455  beta-Adrenergic receptor agonist
   DG01451  beta1-Adrenergic receptor agonist
   DG01452  beta2-Adrenergic receptor agonist
   DG01453  beta3-Adrenergic receptor agonist
 DG01951  Catecholamine adrenergic receptor agonist
 DG01592  COMT substrate
Remark
ATC code: 
Chemical group: 
Efficacy
Antihypotensive, Vasoconstrictor, Adrenergic receptor agonist
Comment
Catecholamine derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137];
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140];
ADRB1 [HSA:153] [KO:K04141];
ADRB2 [HSA:154] [KO:K04142];
ADRB3 [HSA:155] [KO:K04143]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
Metabolism
Enzyme: MAOA [HSA:4128]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA03 Norepinephrine
      D09794  Norepinephrine hydrochloride (JAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Norepinephrine
      D09794  Norepinephrine hydrochloride (JAN)
    alpha2-adrenergic receptor
     Norepinephrine
      D09794  Norepinephrine hydrochloride (JAN)
    beta1-adrenergic receptor
     Norepinephrine
      D09794  Norepinephrine hydrochloride (JAN)
    beta2-adrenergic receptor
     Norepinephrine
      D09794  Norepinephrine hydrochloride (JAN)
    beta3-adrenergic receptor
     Norepinephrine
      D09794  Norepinephrine hydrochloride (JAN)
BRITE hierarchy
Other DBs
CAS: 
55-27-6
PubChem: 
ChEMBL: 
LigandBox: 
KCF data Show

ATOM        13
            1   C8y C    31.0800  -22.1900
            2   C8x C    31.0800  -23.5900
            3   C8x C    29.8200  -21.4900
            4   C1c C    32.2700  -21.4900
            5   C8x C    29.8200  -24.2900
            6   C8y C    28.6300  -22.1900
            7   C1b C    33.4600  -22.1900
            8   O1a O    32.2700  -20.0900
            9   C8y C    28.6300  -23.5900
            10  N1a N    34.6500  -21.4900
            11  O1a O    27.4400  -24.2900
            12  O1a O    27.4400  -21.4900
            13  X   Cl   33.8800  -24.2900
BOND        12
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     4   8 1
            8     5   9 2
            9     7  10 1
            10    9  11 1
            11    6   9 1
            12    6  12 1

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