KEGG   DRUG: D09813Help
Entry
D09813                      Drug                                   

Name
Lenalidomide hydrate (JAN);
Revlimid (TN)
Formula
(C13H13N3O3)2. H2O
Exact mass
536.2019
Mol weight
536.5365
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Immunomulator intended for use in the treatment of multiple myeloma, myelodysplastic syndromes, solid tumors including glioma and metastatic melanoma, Crohn's disease, and heart failure [DS:H00010]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Thalidomide [DR:D00754] derivative
Indication: Multiple myeloma (MM), Myelodysplastic syndromes (MDS)
Lenalidomide is for the type of MDS with a chromosome problem where part of chromosome 5 is missing.
Target
TNF-alpha inhibitor [HSA:7124] [KO:K03156]
Interaction
Genomic biomarker: Chromosome-5q deletion
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AX Other immunosuppressants
     L04AX04 Lenalidomide
      D09813  Lenalidomide hydrate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D09813  Lenalidomide hydrate (JAN)
Target-based classification of drugs [BR:br08310]
 Cytokines
  TNF family
   TNF-alpha
    Lenalidomide
     D09813  Lenalidomide hydrate (JAN)
Antineoplastics [BR:br08308]
 Biologic response modifiers
  Nonspecific immunomodulation
   Lenalidomide
    D09813  Lenalidomide hydrate (JAN)
BRITE hierarchy
Other DBs
PubChem: 
LigandBox: 
KCF data Show

ATOM        39
            1   C8x C    19.9500  -19.5300
            2   C8x C    19.9500  -20.9300
            3   C8x C    21.2100  -21.6300
            4   C8y C    22.4000  -20.9300
            5   C8y C    22.4000  -19.5300
            6   C8y C    21.2100  -18.8300
            7   C5x C    23.7300  -21.4200
            8   N1y N    24.5700  -20.2300
            9   C1x C    23.7300  -19.1100
            10  C1y C    25.9000  -20.2300
            11  O5x O    24.1500  -22.7500
            12  N1a N    21.2100  -17.4300
            13  C1x C    26.6700  -21.4900
            14  C1x C    28.0700  -21.4900
            15  C5x C    28.7700  -20.2300
            16  N1x N    28.0700  -19.0400
            17  C5x C    26.6700  -19.0400
            18  O5x O    25.9700  -17.8500
            19  O5x O    30.1700  -20.2300
            20  O0  O    35.2800  -20.7900
            21  C8x C    19.9500  -19.5300
            22  C8x C    19.9500  -20.9300
            23  C8x C    21.2100  -21.6300
            24  C8y C    22.4000  -20.9300
            25  C8y C    22.4000  -19.5300
            26  C8y C    21.2100  -18.8300
            27  N1a N    21.2100  -17.4300
            28  C1x C    23.7300  -19.1100
            29  N1y N    24.5700  -20.2300
            30  C5x C    23.7300  -21.4200
            31  O5x O    24.1500  -22.7500
            32  C1y C    25.9000  -20.2300
            33  C1x C    26.6700  -21.4900
            34  C1x C    28.0700  -21.4900
            35  C5x C    28.7700  -20.2300
            36  N1x N    28.0700  -19.0400
            37  C5x C    26.6700  -19.0400
            38  O5x O    25.9700  -17.8500
            39  O5x O    30.1700  -20.2300
BOND        42
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    5   9 1
            11    8  10 1
            12    7  11 2
            13    6  12 1
            14   10  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   10  17 1
            20   17  18 2
            21   15  19 2
            22   21  22 2
            23   22  23 1
            24   23  24 2
            25   24  25 1
            26   25  26 2
            27   21  26 1
            28   24  30 1
            29   30  29 1
            30   29  28 1
            31   25  28 1
            32   29  32 1
            33   30  31 2
            34   26  27 1
            35   32  33 1
            36   33  34 1
            37   34  35 1
            38   35  36 1
            39   36  37 1
            40   32  37 1
            41   37  38 2
            42   35  39 2
BRACKET     1    19.1800  -23.8700   19.1800  -16.3100
            1    31.0100  -16.3100   31.0100  -23.8700
            1  2
 ORIGINAL  1    1   2   3   4   5   6  12   9   8   7  11  10  13  14  15  16
            1   17  18  19
 REPEAT    1   21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36
            1   37  38  39

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