KEGG   DRUG: Amuvatinib hydrochlorideHelp
Entry
D09865                      Drug                                   

Name
Amuvatinib hydrochloride (USAN)
Formula
C23H21N5O3S. HCl
Exact mass
483.1132
Mol weight
483.9705
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Remark
Chemical group: 
Activity
Antineoplastic, Tyrosine kinase inhibitor
Target
KIT (CD117) [HSA:3815] [KO:K05091];
AXL [HSA:558] [KO:K05115]
  Pathway
Cytokine-cytokine receptor interaction
Pathways in cancer
Interaction
Drug interaction
Other DBs
CAS: 
1055986-67-8
PubChem: 
LigandBox: 
KCF data Show

ATOM        33
            1   C8y C    21.6300  -29.9600
            2   N5x N    21.6300  -31.3600
            3   C8x C    22.8200  -32.0600
            4   N5x N    24.0800  -31.3600
            5   C8y C    24.0800  -29.9600
            6   C8y C    22.8200  -29.2600
            7   N1y N    25.2700  -29.2600
            8   C1x C    26.4600  -29.9600
            9   C1x C    27.7200  -29.2600
            10  N1y N    27.7200  -27.8600
            11  C1x C    26.5300  -27.1600
            12  C1x C    25.2700  -27.8600
            13  C2c C    28.9100  -27.1600
            14  N1b N    30.1700  -27.8600
            15  C1b C    31.2900  -27.1600
            16  C8y C    32.4800  -27.8600
            17  C8x C    32.4800  -29.2600
            18  C8x C    33.7400  -29.9600
            19  C8y C    34.9300  -29.2600
            20  C8y C    34.9300  -27.8600
            21  C8x C    33.7400  -27.1600
            22  O2x O    36.2600  -29.6800
            23  C1x C    37.1000  -28.5600
            24  O2x O    36.2600  -27.4400
            25  O2x O    22.5400  -27.8600
            26  C8y C    21.1400  -27.7200
            27  C8y C    20.5800  -29.0500
            28  C8x C    20.3700  -26.6000
            29  C8x C    18.9700  -26.7400
            30  C8x C    18.4100  -28.0700
            31  C8x C    19.1800  -29.1900
            32  S0  S    28.9100  -25.7600
            33  X   Cl   30.1000  -31.8500
BOND        37
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13    7  12 1
            14   10  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   16  21 1
            24   19  22 1
            25   22  23 1
            26   23  24 1
            27   20  24 1
            28    6  25 1
            29   25  26 1
            30   26  27 2
            31    1  27 1
            32   26  28 1
            33   28  29 2
            34   29  30 1
            35   30  31 2
            36   27  31 1
            37   13  32 2

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