KEGG   DRUG: D09907Help
Entry
D09907                      Drug                                   

Name
Fulranumab (USAN/INN)
Formula
C6446H9930N1718O2018S50
Exact mass
145293.325
Mol weight
145383.3662
Sequence
(Heavy chain) EVQLVESGGG LVQPGGSLRL SCAASGFTLR SYSMNWVRQA
PGKGLEWVSY ISRSSHTIFY ADSVKGRFTI SRDNAKNSLY LQMDSLRDED TAMYYCARVY
SSGWHVSDYF DYWGQGILVT VSSASTKGPS VFPLAPCSRS TSESTAALGC LVKDYFPEPV
TVSWNSGALT SGVHTFPAVL QSSGLYSLSS VVTVPSSNFG TQTYTCNVDH KPSNTKVDKT
VERKCCVECP PCPAPPVAGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVQFNWY
VDGVEVHNAK TKPREEQFNS TFRVVSVLTV VHQDWLNGKE YKCKVSNKGL PAPIEKTISK
TKGQPREPQV YTLPPSREEM TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPML
DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
(Disulfide bridge: 22-96; 150-206; 263-323; 369-427, Dimer: 225; 226; 229; 232)
(Light chain) AIQLTQSPSS LSASVGDRVT ITCRASQGIS SALAWYQQKP
GKAPKLLIYD ASSLESGVPS RFSGSGSGTD FTLTISSLQP EDFATYYCQQ FNSYPLTFGG
GTKVEIKRTV AAPSVFIFPP SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ
ESVTEQDSKD STYSLSSTLT LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: 23-88; 134-194; H137-L214, Dimer)
  Type
Peptide
Activity
Treatment of pain
Comment
monoclonal antibody
Target
NGF [HSA:4803] [KO:K02582]
  Pathway
hsa04010  MAPK signaling pathway
hsa04210  Apoptosis
hsa04722  Neurotrophin signaling pathway  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines
  PDGF family
   NGF
    Fulranumab
     D09907  Fulranumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
902141-80-4
PubChem: 

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