KEGG   DRUG: D09908Help
Entry
D09908                      Drug                                   

Name
Ganitumab (USAN/INN)
Formula
C6472H10028N1728O2020S42
Exact mass
145620.3358
Mol weight
145709.9683
Sequence
(Heavy chain) QVQLQESGPG LVKPSGTLSL TCAVSGGSIS SSNWWSWVRQ
PPGKGLEWIG EIYHSGSTNY NPSLKSRVTI SVDKSKNQFS LKLSSVTAAD TAVYYCARWT
GRTDAFDIWG QGTMVTVSSA STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW
NSGALTSGVH TFPAVLQSSG LYSLSSVVTV PSSSLGTQTY ICNVNHKPSN TKVDKKVEPK
SCDKTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY
VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK
AKGQPREPQV YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL
DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
(Disulfide bridge: 22-96; 146-202; 263-323; 369-427, Dimer: 228; 231)
(Light chain) DVVMTQSPLS LPVTPGEPAS ISCRSSQSLL HSNGYNYLDW
YLQKPGQSPQ LLIYLGSNRA SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCMQGTHWP
LTFGQGTKVE IKRTVAAPSV FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ
SGNSQESVTE QDSKDSTYSL SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(Disulfide bridge: 23-93; 139-199; H222-L219, Dimer)
  Type
Peptide
Activity
Treatment of cancer
Comment
monoclonal antibody
Target
insulin-like growth factor 1 receptor [HSA:3480] [KO:K05087]
  Pathway
hsa04510  Focal adhesion
hsa04520  Adherens junction
hsa05200  Pathways in cancer  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class II (Insulin receptor family)
    insulin-like growth factor 1 receptor
     Ganitumab
      D09908  Ganitumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
905703-97-1
PubChem: 

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