KEGG   DRUG: D09911Help
Entry
D09911                      Drug                                   

Name
Gevokizumab (USAN/INN)
Formula
C6442H9962N1710O2010S52
Exact mass
145101.5356
Mol weight
145191.6587
Sequence
(Heavy chain) QVQLQESGPG LVKPSQTLSL TCSFSGFSLS TSGMGVGWIR
QPSGKGLEWL AHIWWDGDES YNPSLKSRLT ISKDTSKNQV SLKITSVTAA DTAVYFCARN
RYDPPWFVDW GQGTLVTVSS ASTKGPSVFP LAPCSRSTSE STAALGCLVK DYFPEPVTVS
WNSGALTSGV HTFPAVLQSS GLYSLSSVVT VTSSNFGTQT YTCNVDHKPS NTKVDKTVER
KCCVECPPCP APPVAGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVQFNWYVDG
MEVHNAKTKP  REEQFNSTFR  300 VVSVLTVVHQ  DWLNGKEYKC  KVSNKGLPAP
IEKTISKTKG  QPREPQVYTL  PPSREEMTKN  QVSLTCLVKG  FYPSDIAVEW
ESNGQPENNY  KTTPPMLDSD  GSFFLYSKLT  VDKSRWQQGN  VFSCSVMHEA
LHNHYTQKSL  SLSPG
(Disulfide bridge: 22-97; 147-203; 260-320; 366-424, Dimer: 222; 223; 226; 229)
(Light chain) DIQMTQSTSS LSASVGDRVT ITCRASQDIS NYLSWYQQKP
GKAVKLLIYY TSKLHSGVPS RFSGSGSGTD YTLTISSLQQ EDFATYFCLQ GKMLPWTFGQ
GTKLEIKRTV AAPSVFIFPP SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ
ESVTEQDSKD STYSLSSTLT LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: 23-88; 134-194; H134-L214, Dimer)
  Type
Peptide
Activity
Treatment of diabetes, inflammatory disorders
Comment
monoclonal antibody
Target
interleukin-1beta (IL1B) [HSA:3553] [KO:K04519]
  Pathway
hsa04010  MAPK signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04621  NOD-like receptor signaling pathway  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines
  IL-1 family
   IL-1B
    Gevokizumab
     D09911  Gevokizumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
1129435-60-4
PubChem: 

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