KEGG   DRUG: D09917Help
Entry
D09917                      Drug                                   
Name
Latrepirdine (USAN/INN)
Formula
C21H25N3
Exact mass
319.2048
Mol weight
319.4433
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of Alzheimer's disease
Target
acetylcholinesterase (AChE) inhibitor [HSA:43] [KO:K01049];
N-methyl-D-aspartate receptor antagonist [HSA:2902 2903 2904 2905 2906] [KO:K05208 K05209 K05210 K05211 K05212]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
hsa04725  Cholinergic synapse
hsa05010  Alzheimer's disease  
 
Brite
Target-based classification of drugs [BR:br08310]
 Ion channels
  Glutamate-gated cation channels
   Glutamate (ionotropic), NMDA
    N-methyl-D-aspartate receptor [HSA:2902 2903 2904 2905 2906] [KO:K05208 K05209 K05210 K05211 K05212]
     Latrepirdine
      D09917  Latrepirdine (USAN/INN)
 Enzymes
  Hydrolases
   acetylcholinesterase (AChE) [HSA:43] [KO:K01049]
    Latrepirdine
     D09917  Latrepirdine (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
3613-73-8
PubChem: 
LigandBox: 
KCF data Show

ATOM        24
            1   C8y C    19.9065  -28.4433
            2   C8y C    21.3057  -28.3959
            3   C8y C    21.6930  -27.0505
            4   N4y N    20.5331  -26.2664
            5   C8y C    19.4290  -27.1272
            6   C8x C    22.2771  -29.4040
            7   C8y C    23.6359  -29.0667
            8   C8x C    24.0232  -27.7213
            9   C8x C    23.0517  -26.7132
            10  C1x C    18.0505  -26.8826
            11  C1x C    17.1495  -27.9541
            12  N1y N    17.6270  -29.2702
            13  C1x C    19.0054  -29.5148
            14  C1b C    20.4855  -24.8502
            15  C1b C    21.6913  -24.0987
            16  C8y C    21.7134  -22.6811
            17  C8x C    22.9268  -22.0054
            18  N5x N    22.9485  -20.6056
            19  C8y C    21.7470  -19.8869
            20  C8x C    20.5336  -20.5626
            21  C8x C    20.5119  -21.9624
            22  C1a C    21.7687  -18.4800
            23  C1a C    24.6103  -30.0780
            24  C1a C    16.7364  -30.3293
BOND        27
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 1
            5     1   5 2
            6     2   6 1
            7     6   7 2
            8     7   8 1
            9     8   9 2
            10    3   9 1
            11    5  10 1
            12   10  11 1
            13   11  12 1
            14   12  13 1
            15    1  13 1
            16    4  14 1
            17   14  15 1
            18   15  16 1
            19   16  17 1
            20   17  18 2
            21   18  19 1
            22   19  20 2
            23   20  21 1
            24   16  21 2
            25   19  22 1
            26    7  23 1
            27   12  24 1

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