KEGG   DRUG: LatrepirdineHelp
Entry
D09917                      Drug                                   

Name
Latrepirdine (USAN/INN)
Formula
C21H25N3
Exact mass
319.2048
Mol weight
319.4433
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01595  Cholinesterase inhibitor
  DG01593  Acetylcholinesterase inhibitor
 DG01498  NMDA receptor antagonist
Unclassified
 DG01968  Agents for Alzheimer-type dementia
Remark
Chemical group: 
Activity
Nootropic
Comment
Treatment of Alzheimer's disease
Target
ACHE [HSA:43] [KO:K01049];
GRIN (NMDAR) [HSA:2902 2903 2904 2905 2906] [KO:K05208 K05209 K05210 K05211 K05212]
  Pathway
Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cholinergic synapse
Alzheimer's disease
Interaction
Drug interaction
Structure map
Agents for Alzheimer-type dementia
Brite
Target-based classification of drugs [BR:br08310]
 Ion channels
  Glutamate-gated cation channels
   Glutamate (ionotropic), NMDA
    N-methyl-D-aspartate receptor
     Latrepirdine
      D09917  Latrepirdine (USAN/INN)
 Enzymes
  Hydrolases
   acetylcholinesterase (AChE)
    Latrepirdine
     D09917  Latrepirdine (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
3613-73-8
PubChem: 
LigandBox: 
KCF data Show

ATOM        24
            1   C8y C    19.9065  -28.4433
            2   C8y C    21.3057  -28.3959
            3   C8y C    21.6930  -27.0505
            4   N4y N    20.5331  -26.2664
            5   C8y C    19.4290  -27.1272
            6   C8x C    22.2771  -29.4040
            7   C8y C    23.6359  -29.0667
            8   C8x C    24.0232  -27.7213
            9   C8x C    23.0517  -26.7132
            10  C1x C    18.0505  -26.8826
            11  C1x C    17.1495  -27.9541
            12  N1y N    17.6270  -29.2702
            13  C1x C    19.0054  -29.5148
            14  C1b C    20.4855  -24.8502
            15  C1b C    21.6913  -24.0987
            16  C8y C    21.7134  -22.6811
            17  C8x C    22.9268  -22.0054
            18  N5x N    22.9485  -20.6056
            19  C8y C    21.7470  -19.8869
            20  C8x C    20.5336  -20.5626
            21  C8x C    20.5119  -21.9624
            22  C1a C    21.7687  -18.4800
            23  C1a C    24.6103  -30.0780
            24  C1a C    16.7364  -30.3293
BOND        27
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 1
            5     1   5 2
            6     2   6 1
            7     6   7 2
            8     7   8 1
            9     8   9 2
            10    3   9 1
            11    5  10 1
            12   10  11 1
            13   11  12 1
            14   12  13 1
            15    1  13 1
            16    4  14 1
            17   14  15 1
            18   15  16 1
            19   16  17 1
            20   17  18 2
            21   18  19 1
            22   19  20 2
            23   20  21 1
            24   16  21 2
            25   19  22 1
            26    7  23 1
            27   12  24 1

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