KEGG   DRUG: D09919Help
Entry
D09919                      Drug                                   
Name
Lenvatinib (USAN/INN)
Formula
C21H19ClN4O4
Exact mass
426.1095
Mol weight
426.853
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antineoplastic
Target
vascular endothelial growth factor receptor (VEGFR) inhibitor [HSA:2321] [KO:K05096];
fibroblast growth factor receptor (FGFR) inhibitor [HSA:2260 2263 2261 2264] [KO:K04362 K05093 K05094 K05095];
platelet derived growth factor receptor inhibitor [HSA:5156 5159] [KO:K04363 K05089]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04510  Focal adhesion
hsa05200  Pathways in cancer  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class III (PDGF receptor family)
    PDGFRA tyrosine kinase [HSA:5156] [KO:K04363]
     Lenvatinib
      D09919  Lenvatinib (USAN/INN)
    PDGFRB tyrosine kinase [HSA:5159] [KO:K05089]
     Lenvatinib
      D09919  Lenvatinib (USAN/INN)
   RTK class IV (FGF receptor family)
    fibroblast growth factor receptor 1 [HSA:2260] [KO:K04362]
     Lenvatinib
      D09919  Lenvatinib (USAN/INN)
    fibroblast growth factor receptor 2 [HSA:2263] [KO:K05093]
     Lenvatinib
      D09919  Lenvatinib (USAN/INN)
    fibroblast growth factor receptor 3 [HSA:2261] [KO:K05094]
     Lenvatinib
      D09919  Lenvatinib (USAN/INN)
    fibroblast growth factor receptor 4 [HSA:2264] [KO:K05095]
     Lenvatinib
      D09919  Lenvatinib (USAN/INN)
   RTK class V (VEGF receptor family)
    VEGFR1 tyrosine kinase [HSA:2321] [KO:K05096]
     Lenvatinib
      D09919  Lenvatinib (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
417716-92-8
PubChem: 
LigandBox: 
KCF data Show

ATOM        30
            1   C8y C     8.9600  -18.7600
            2   C8y C     8.9600  -20.1600
            3   C8x C    10.1724  -20.8600
            4   C8y C    11.3849  -20.1600
            5   C8y C    11.3849  -18.7600
            6   C8x C    10.1724  -18.0600
            7   C8y C    12.5973  -20.8600
            8   C8x C    13.8097  -20.1600
            9   C8x C    13.8097  -18.7600
            10  N5x N    12.5973  -18.0600
            11  O2a O    12.5973  -22.2600
            12  C8y C    13.8118  -22.9612
            13  C8x C    13.8117  -24.3598
            14  C8y C    15.0242  -25.0599
            15  C8y C    16.2366  -24.3599
            16  C8x C    16.2366  -22.9612
            17  C8x C    15.0242  -22.2612
            18  O2a O     7.7476  -18.0600
            19  C5a C     7.7476  -20.8600
            20  N1a N     6.5521  -20.1696
            21  O5a O     7.7475  -22.2598
            22  X   Cl   15.0241  -26.4598
            23  N1b N    17.4516  -25.0614
            24  C5a C    18.6483  -24.3703
            25  N1b N    19.8350  -25.0555
            26  O5a O    18.6485  -22.9603
            27  C1a C     6.5521  -18.7504
            28  C1y C    21.0267  -24.3674
            29  C1x C    22.4267  -24.3674
            30  C1x C    21.7267  -23.1549
BOND        33
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12    7  11 1
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 2
            19   12  17 1
            20    1  18 1
            21    2  19 1
            22   19  20 1
            23   19  21 2
            24   14  22 1
            25   15  23 1
            26   23  24 1
            27   24  25 1
            28   24  26 2
            29   18  27 1
            30   25  28 1
            31   28  29 1
            32   28  30 1
            33   30  29 1

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