KEGG   DRUG: D09920Help
Entry
D09920                      Drug                                   

Name
Lenvatinib mesilate (JAN);
Lenvatinib mesylate (USAN)
Formula
C21H19ClN4O4. CH4SO3
Exact mass
522.0976
Mol weight
522.9586
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antineoplastic
Target
vascular endothelial growth factor receptor (VEGFR) inhibitor [HSA:2321] [KO:K05096];
fibroblast growth factor receptor (FGFR) inhibitor [HSA:2260 2263 2261 2264] [KO:K04362 K05093 K05094 K05095];
platelet derived growth factor receptor inhibitor [HSA:5156 5159] [KO:K04363 K05089]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04510  Focal adhesion
hsa05200  Pathways in cancer  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class III (PDGF receptor family)
    PDGFRA tyrosine kinase
     Lenvatinib
      D09920  Lenvatinib mesilate (JAN); Lenvatinib mesylate (USAN)
    PDGFRB tyrosine kinase
     Lenvatinib
      D09920  Lenvatinib mesilate (JAN); Lenvatinib mesylate (USAN)
   RTK class IV (FGF receptor family)
    fibroblast growth factor receptor 1
     Lenvatinib
      D09920  Lenvatinib mesilate (JAN); Lenvatinib mesylate (USAN)
    fibroblast growth factor receptor 2
     Lenvatinib
      D09920  Lenvatinib mesilate (JAN); Lenvatinib mesylate (USAN)
    fibroblast growth factor receptor 3
     Lenvatinib
      D09920  Lenvatinib mesilate (JAN); Lenvatinib mesylate (USAN)
    fibroblast growth factor receptor 4
     Lenvatinib
      D09920  Lenvatinib mesilate (JAN); Lenvatinib mesylate (USAN)
   RTK class V (VEGF receptor family)
    VEGFR1 tyrosine kinase
     Lenvatinib
      D09920  Lenvatinib mesilate (JAN); Lenvatinib mesylate (USAN)
BRITE hierarchy
Other DBs
CAS: 
857890-39-2
PubChem: 
LigandBox: 
KCF data Show

ATOM        35
            1   C8y C    12.8800  -22.4700
            2   C8y C    12.8800  -23.8700
            3   C8x C    14.1400  -24.5700
            4   C8y C    15.3300  -23.8700
            5   C8y C    15.3300  -22.4700
            6   C8x C    14.1400  -21.7700
            7   C8y C    16.5200  -24.5700
            8   C8x C    17.7800  -23.8700
            9   C8x C    17.7800  -22.4700
            10  N5x N    16.5200  -21.7700
            11  O2a O    16.5200  -25.9700
            12  C8y C    17.7800  -26.6700
            13  C8x C    17.7800  -28.0700
            14  C8y C    18.9700  -28.7700
            15  C8y C    20.1600  -28.0700
            16  C8x C    20.1600  -26.6700
            17  C8x C    18.9700  -25.9700
            18  O2a O    11.6900  -21.7700
            19  C5a C    11.6900  -24.5700
            20  N1a N    10.5000  -23.8700
            21  O5a O    11.6900  -25.9700
            22  X   Cl   18.9700  -30.1700
            23  N1b N    21.4200  -28.7700
            24  C5a C    22.6100  -28.0700
            25  N1b N    23.8000  -28.7700
            26  O5a O    22.6100  -26.6700
            27  C1a C    10.5000  -22.4000
            28  C1y C    24.9900  -28.0700
            29  C1x C    26.3900  -28.0700
            30  C1x C    25.6900  -26.8100
            31  C1a C    21.2100  -23.1700
            32  S4a S    22.6100  -23.1700
            33  O1d O    24.0100  -23.1700
            34  O1d O    22.6100  -21.7700
            35  O1d O    22.6100  -24.5700
BOND        37
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12    7  11 1
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 2
            19   12  17 1
            20    1  18 1
            21    2  19 1
            22   19  20 1
            23   19  21 2
            24   14  22 1
            25   15  23 1
            26   23  24 1
            27   24  25 1
            28   24  26 2
            29   18  27 1
            30   25  28 1
            31   28  29 1
            32   28  30 1
            33   30  29 1
            34   31  32 1
            35   32  33 1
            36   32  34 2
            37   32  35 2

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