KEGG   DRUG: Lenvatinib mesylateHelp
Entry
D09920                      Drug                                   

Name
Lenvatinib mesylate (USAN);
Lenvatinib mesilate (JAN);
Lenvima (TN)
Product
Formula
C21H19ClN4O4. CH4SO3
Exact mass
522.0976
Mol weight
522.9586
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antineoplastic
  Disease
Thyroid cancer [DS:H00032]
Renal cell carcinoma [DS:H00021]
Target
VEGFR1 (FLT1) [HSA:2321] [KO:K05096];
FGFR [HSA:2260 2263 2261 2264] [KO:K04362 K05093 K05094 K05095];
PDGFRA [HSA:5156] [KO:K04363];
PDGFRB [HSA:5159] [KO:K05089]
  Pathway
MAPK signaling pathway
Calcium signaling pathway
Cytokine-cytokine receptor interaction
Focal adhesion
Pathways in cancer
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Transporter: ABCB1 [HSA:5243]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XE Protein kinase inhibitors
     L01XE29 Lenvatinib
      D09920  Lenvatinib mesylate (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D09920  Lenvatinib mesylate (USAN); Lenvatinib mesilate (JAN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class III (PDGF receptor family)
    PDGFRA tyrosine kinase
     Lenvatinib
      D09920  Lenvatinib mesylate (USAN)
    PDGFRB tyrosine kinase
     Lenvatinib
      D09920  Lenvatinib mesylate (USAN)
   RTK class IV (FGF receptor family)
    fibroblast growth factor receptor 1
     Lenvatinib
      D09920  Lenvatinib mesylate (USAN)
    fibroblast growth factor receptor 2
     Lenvatinib
      D09920  Lenvatinib mesylate (USAN)
    fibroblast growth factor receptor 3
     Lenvatinib
      D09920  Lenvatinib mesylate (USAN)
    fibroblast growth factor receptor 4
     Lenvatinib
      D09920  Lenvatinib mesylate (USAN)
   RTK class V (VEGF receptor family)
    VEGFR1 tyrosine kinase
     Lenvatinib
      D09920  Lenvatinib mesylate (USAN)
Antineoplastics [br08340.html]
 D09920
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D09920
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D09920
BRITE hierarchy
Other DBs
CAS: 
857890-39-2
PubChem: 
LigandBox: 
KCF data Show

ATOM        35
            1   C8y C    12.8800  -22.4700
            2   C8y C    12.8800  -23.8700
            3   C8x C    14.1400  -24.5700
            4   C8y C    15.3300  -23.8700
            5   C8y C    15.3300  -22.4700
            6   C8x C    14.1400  -21.7700
            7   C8y C    16.5200  -24.5700
            8   C8x C    17.7800  -23.8700
            9   C8x C    17.7800  -22.4700
            10  N5x N    16.5200  -21.7700
            11  O2a O    16.5200  -25.9700
            12  C8y C    17.7800  -26.6700
            13  C8x C    17.7800  -28.0700
            14  C8y C    18.9700  -28.7700
            15  C8y C    20.1600  -28.0700
            16  C8x C    20.1600  -26.6700
            17  C8x C    18.9700  -25.9700
            18  O2a O    11.6900  -21.7700
            19  C5a C    11.6900  -24.5700
            20  N1a N    10.5000  -23.8700
            21  O5a O    11.6900  -25.9700
            22  X   Cl   18.9700  -30.1700
            23  N1b N    21.4200  -28.7700
            24  C5a C    22.6100  -28.0700
            25  N1b N    23.8000  -28.7700
            26  O5a O    22.6100  -26.6700
            27  C1a C    10.5000  -22.4000
            28  C1y C    24.9900  -28.0700
            29  C1x C    26.3900  -28.0700
            30  C1x C    25.6900  -26.8100
            31  C1a C    21.2100  -23.1700
            32  S4a S    22.6100  -23.1700
            33  O1d O    24.0100  -23.1700
            34  O1d O    22.6100  -21.7700
            35  O1d O    22.6100  -24.5700
BOND        37
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12    7  11 1
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 2
            19   12  17 1
            20    1  18 1
            21    2  19 1
            22   19  20 1
            23   19  21 2
            24   14  22 1
            25   15  23 1
            26   23  24 1
            27   24  25 1
            28   24  26 2
            29   18  27 1
            30   25  28 1
            31   28  29 1
            32   28  30 1
            33   30  29 1
            34   31  32 1
            35   32  33 1
            36   32  34 2
            37   32  35 2

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