KEGG   DRUG: D09926Help
Entry
D09926                      Drug                                   

Name
Icrucumab (USAN/INN)
Formula
C6514H10024N1756O2032S42
Exact mass
146704.3296
Mol weight
146794.5664
Sequence
(Heavy chain) QAQVVESGGG VVQSGRSLRL SCAASGFAFS SYGMHWVRQA
PGKGLEWVAV IWYDGSNKYY ADSVRGRFTI SRDNSENTLY LQMNSLRAED TAVYYCARDH
YGSGVHHYFY YGLDVWGQGT TVTVSSASTK GPSVFPLAPS SKSTSGGTAA LGCLVKDYFP
EPVTVSWNSG ALTSGVHTFP AVLQSSGLYS LSSVVTVPSS SLGTQTYICN VNHKPSNTKV
DKRVEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP
EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP
IEKTISKAKG QPREPQVYTL PPSREEMTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY
KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGK
(Disulfide bridge: 22-96; 153-209; 270-330; 376-434, Dimer: 235; 238)
(Light chain) EIVLTQSPGT LSLSPGERAT LSCRASQSVS SSYLAWYQQK
PGQAPRLLIY GASSRATGIP DRFSGSGSGT DFTLTISRLE PEDFAVYYCQ QYGSSPLTFG
GGTKVEIKRT VAAPSVFIFP PSDEQLKSGT ASVVCLLNNF YPREAKVQWK VDNALQSGNS
QESVTEQDSK DSTYSLSSTL TLSKADYEKH KVYACEVTHQ GLSSPVTKSF NRGEC
(Disulfide bridge: 23-89; 135-195; H229-L215, Dimer)
  Type
Peptide
Activity
Treatment of solid tumors
Comment
Monoclonal antibody
Target
VEGFR1 tyrosine kinase [HSA:2321] [KO:K05096]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04144  Endocytosis
hsa04510  Focal adhesion  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class V (VEGF receptor family)
    VEGFR1 tyrosine kinase [HSA:2321] [KO:K05096]
     Icrucumab
      D09926  Icrucumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
1024603-92-6
PubChem: 

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