KEGG   DRUG: D09930Help
Entry
D09930                      Drug                                   

Name
Mavrilimumab (USAN/INN)
Formula
C6706H10438N1762O2104S54
Exact mass
151044.8863
Mol weight
151138.6849
Sequence
(Heavy chain) QVQLVQSGAE VKKPGASVKV SCKVSGYTLT ELSIHWVRQA
PGKGLEWMGG FDPEENEIVY AQRFQGRVTM TEDTSTDTAY MELSSLRSED TAVYYCAIVG
SFSPLTLGLW GQGTMVTVSS ASTKGPSVFP LAPCSRSTSE STAALGCLVK DYFPEPVTVS
WNSGALTSGV HTFPAVLQSS GLYSLSSVVT VPSSSLGTKT YTCNVDHKPS NTKVDKRVES
KYGPPCPSCP APEFLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSQED PEVQFNWYVD
GVEVHNAKTK PREEQFNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKGLPS SIEKTISKAK
GQPREPQVYT LPPSQEEMTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS
DGSFFLYSRL TVDKSRWQEG NVFSCSVMHE ALHNHYTQKS LSLSLGK
(Disulfide bridge: 22-96; 147-203; 261-321; 367-425, Dimer: 226; 229)
(Light chain) QSVLTQPPSV SGAPGQRVTI SCTGSGSNIG APYDVSWYQQ
LPGTAPKLLI YHNNKRPSGV PDRFSGSKSG TSASLAITGL QAEDEADYYC ATVEAGLSGS
VFGGGTKLTV LGQPKAAPSV TLFPPSSEEL QANKATLVCL ISDFYPGAVT VAWKADSSPV
KAGVETTTPS KQSNNKYAAS SYLSLTPEQW KSHRSYSCQV THEGSTVEKT VAPTECS
(Disulfide bridge: 22-90; 139-198; H134-L216, Dimer)
  Type
Peptide
Activity
Treatment of rheumatoid arthritis [DS:H00630]
Comment
Monoclonal antibody
Target
GM-CSF receptor alpha (CD116) [HSA:1438] [KO:K05066]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  Jak-STAT signaling pathway  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Class I cytokine receptors (hematopoietin family receptors)
   granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha
    Mavrilimumab
     D09930  Mavrilimumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
1085337-57-0
PubChem: 

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