KEGG   DRUG: OlaratumabHelp
Entry
D09939                      Drug                                   

Name
Olaratumab (USAN/INN);
Lartruvo (TN)
Product
Formula
C6554H10076N1736O2048S40
Exact mass
147148.6495
Mol weight
147239.1336
Sequence
(Heavy chain) QLQLQESGPG LVKPSETLSL TCTVSGGSIN SSSYYWGWLR
QSPGKGLEWI GSFFYTGSTY YNPSLRSRLT ISVDTSKNQF SLMLSSVTAA DTAVYYCARQ
STYYYGSGNY YGWFDRWDQG TLVTVSSAST KGPSVFPLAP SSKSTSGGTA ALGCLVKDYF
PEPVTVSWNS GALTSGVHTF PAVLQSSGLY SLSSVVTVPS SSLGTQTYIC NVNHKPSNTK
VDKRVEPKSC DKTHTCPPCP APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED
PEVKFNWYVD GVEVHNAKTK PREEQYNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKALPA
PIEKTISKAK GQPREPQVYT LPPSREEMTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN
YKTTPPVLDS DGSFFLYSKL TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSPGK
(Disulfide bridge:22-97; 154-210; 271-331; 377-435, Dimer: 236; 239)
(Light chain) EIVLTQSPAT LSLSPGERAT LSCRASQSVS SYLAWYQQKP
GQAPRLLIYD ASNRATGIPA RFSGSGSGTD FTLTISSLEP EDFAVYYCQQ RSNWPPAFGQ
GTKVEIKRTV AAPSVFIFPP SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ
ESVTEQDSKD STYSLSSTLT LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: 23-88; 134-194; H230-L214, Dimer)
  Type
Peptide
Activity
Antineoplastic, Anti-platelet-derived growth factor (PDGF) receptor alpha antibody
  Disease
Soft tissue sarcoma
Comment
Monoclonal antibody
Treatment of solid tumors
Target
PDGFRA [HSA:5156] [KO:K04363]
  Pathway
MAPK signaling pathway
Calcium signaling pathway
Cytokine-cytokine receptor interaction
Focal adhesion
Gap junction
Regulation of actin cytoskeleton
Brite
USP drug classification [BR:br08302]
 Antineoplastics
  Monoclonal Antibody/Antibody-Drug Conjugate
   Olaratumab
    D09939  Olaratumab (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class III (PDGF receptor family)
    PDGFRA tyrosine kinase
     Olaratumab
      D09939  Olaratumab (USAN/INN)
Antineoplastics [br08340.html]
 D09939
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D09939
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09939
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09939
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D09939
BRITE hierarchy
Other DBs
CAS: 
1024603-93-7
PubChem: 

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