KEGG   DRUG: D09941Help
Entry
D09941                      Drug                                   

Name
Onartuzumab (genetical recombination) (JAN);
Onartuzumab (USAN/INN)
Formula
C4422H6820N1168O1363S31
Exact mass
99085.16
Mol weight
99146.489
Sequence
(A chain)
EVQLVESGGG LVQPGGSLRL SCAASGYTFT SYWLHWVRQA PGKGLEWVGM IDPSNSDTRF
NPNFKDRFTI SADTSKNTAY LQMNSLRAED TAVYYCATYR SYVTPLDYWG QGTLVTVSSA
STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW NSGALTSGVH TFPAVLQSSG
LYSLSSVVTV PSSSLGTQTY ICNVNHKPSN TKVDKKVEPK SCDKTHTCPP CPAPELLGGP
SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS
TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSREEM
TKNQVSLSCA VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLVS KLTVDKSRWQ
QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
(B chain)
DKTHTCPPCP APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD
GVEVHNAKTK PREEQYNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK
GQPREPQVYT LPPSREEMTK NQVSLWCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS
DGSFFLYSKL TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSPGK
(C chain)
DIQMTQSPSS LSASVGDRVT ITCKSSQSLL YTSSQKNYLA WYQQKPGKAP KLLIYWASTR
ESGVPSRFSG SGSGTDFTLT ISSLQPEDFA TYYCQQYYAY PWTFGQGTKV EIKRTVAAPS
VFIFPPSDEQ LKSGTASVVC LLNNFYPREA KVQWKVDNAL QSGNSQESVT EQDSKDSTYS
LSSTLTLSKA DYEKHKVYAC EVTHQGLSSP VTKSFNRGEC
(Disulfide bridge: A22-A96, A146-A202, A222-C220, A228-B6, A231-B9, A263-A323, A369-A427, B41-B101, B147-B205, C23-C94, C140-C200)
  Type
Peptide
Activity
Treatment of cancer
Comment
monoclonal antibody
Target
met proto-oncogene (c-Met) [HSA:4233] [KO:K05099]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04510  Focal adhesion
hsa04520  Adherens junction  
 
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Tyrosine protein kinases
   Met family
    MET
     Onartuzumab
      D09941  Onartuzumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
1133766-06-9
PubChem: 

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