KEGG   DRUG: D09967Help
Entry
D09967                      Drug                                   

Name
Secukinumab (genetical recombination) (JAN);
Secukinumab (USAN/INN)
Formula
C6584H10134N1754O2042S44
Exact mass
147851.0774
Mol weight
147942.2994
Sequence
(Heavy chain) EVQLVESGGG LVQPGGSLRL SCAASGFTFS NYWMNWVRQA
PGKGLEWVAA INQDGSEKYY VGSVKGRFTI SRDNAKNSLY LQMNSLRVED TAVYYCVRDY
YDILTDYYIH YWYFDLWGRG TLVTVSSAST KGPSVFPLAP SSKSTSGGTA ALGCLVKDYF
PEPVTVSWNS GALTSGVHTF PAVLQSSGLY SLSSVVTVPS SSLGTQTYIC NVNHKPSNTK
VDKRVEPKSC DKTHTCPPCP APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED
PEVKFNWYVD GVEVHNAKTK PREEQYNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKALPA
PIEKTISKAK GQPREPQVYT LPPSREEMTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN
YKTTPPVLDS DGSFFLYSKL TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSPGK
(Disulfide bridge: 22-96; 154-210; 271-331; 377-435, Dimer: 236; 239)
(Light chain) EIVLTQSPGT LSLSPGERAT LSCRASQSVS SSYLAWYQQK
PGQAPRLLIY GASSRATGIP DRFSGSGSGT DFTLTISRLE PEDFAVYYCQ QYGSSPCTFG
QGTRLEIKRT VAAPSVFIFP PSDEQLKSGT ASVVCLLNNF YPREAKVQWK VDNALQSGNS
QESVTEQDSK DSTYSLSSTL TLSKADYEKH KVYACEVTHQ GLSSPVTKSF NRGEC
(Disulfide bridge: 23-89; 135-195; H230-L215, Dimer)
  Type
Peptide
Activity
Uveitis, rheumatoid arthritis, psoriasis
Remark
ATC code: 
Comment
Monoclonal antibody
Target
interleukin 17A [HSA:3605] [KO:K05489]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa05323  Rheumatoid arthritis  
 
Interaction
Drug interaction
Structure map
Antirheumatics - DMARDs and biological agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AC Interleukin inhibitors
     L04AC10 Secukinumab
      D09967  Secukinumab (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Cytokines
  IL-17 family
   IL-17A
    Secukinumab
     D09967  Secukinumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
1229022-83-6
PubChem: 

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