KEGG   DRUG: D09979Help
Entry
D09979                      Drug                                   

Name
Tralokinumab (USAN/INN)
Formula
C6374H9822N1698O2014S44
Exact mass
143784.6063
Mol weight
143873.2167
Sequence
(Heavy chain) QVQLVQSGAE VKKPGASVKV SCKASGYTFT NYGLSWVRQA
PGQGLEWMGW ISANNGDTNY GQEFQGRVTM TTDTSTSTAY MELRSLRSDD TAVYYCARDS
SSSWARWFFD LWGRGTLVTV SSASTKGPSV FPLAPCSRST SESTAALGCL VKDYFPEPVT
VSWNSGALTS GVHTFPAVLQ SSGLYSLSSV VTVPSSSLGT KTYTCNVDHK PSNTKVDKRV
ESKYGPPCPS CPAPEFLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSQ EDPEVQFNWY
VDGVEVHNAK TKPREEQFNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKGL PSSIEKTISK
AKGQPREPQV YTLPPSQEEM TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL
DSDGSFFLYS RLTVDKSRWQ EGNVFSCSVM HEALHNHYTQ KSLSLSLGK
(Disulfide bridge: 22-96; 149-205; 263-323; 369-427, Dimer: 228; 231)
(Light chain) SYVLTQPPSV SVAPGKTARI TCGGNIIGSK LVHWYQQKPG
QAPVLVIYDD GDRPSGIPER FSGSNSGNTA TLTISRVEAG DEADYYCQVW DTGSDPVVFG
GGTKLTVLGQ PKAAPSVTLF PPSSEELQAN KATLVCLISD FYPGAVTVAW KADSSPVKAG
VETTTPSKQS NNKYAASSYL SLTPEQWKSH RSYSCQVTHE GSTVEKTVAP TECS
(Disulfide bridge: 22-87; 136-195; H136-L213, Dimer)
  Type
Peptide
Activity
Treatment of asthma and inflammatory diseases
Comment
Monoclonal antibody
Target
IL-13 [HSA:3596] [KO:K05435]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  Jak-STAT signaling pathway  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines
  Class I cytokines
   IL-13
    Tralokinumab
     D09979  Tralokinumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
1044515-88-9
PubChem: 

» Japanese version   » Back

DBGET integrated database retrieval system