KEGG   DRUG: Trastuzumab emtansineHelp
Entry
D09980                      Drug                                   

Name
Trastuzumab emtansine (USAN/INN);
Trastuzumab emtansine (genetical recombination) (JAN);
Ado-trastuzumab emtansine;
Kadcyla (TN)
Product
Formula
C6448H9948N1720O2012S44
Exact mass
145075.67
Mol weight
145165.1575
Remark
Therapeutic category: 4291
ATC code: L01XC14
Product: D09980<JP/US>
Efficacy
Antineoplastic, Tubulin polymerization inhibitor, Receptor tyrosine kinase inhibitor, Anti-HER2 antibody
  Disease
Breast cancer (HER2 positive) [DS:H00031]
Comment
Antibody-drug conjugate
Target
ERBB2 (HER2, CD340) [HSA_VAR:2064v1 2064v3] [HSA:2064] [KO:K05083] (trastuzumab)
TUBB [HSA:10381 10382 10383 203068 347688 347733 7280 81027 84617] [KO:K07375] (emtansine)
  Network
N10009  Tyrosine kinase inhibitor to HER2 overexpression/amplification
  Pathway
hsa04012  ErbB signaling pathway
hsa05200  Pathways in cancer
hsa05224  Breast cancer
Structure map
map07045  Antineoplastics - protein kinases inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XC Monoclonal antibodies
     L01XC14 Trastuzumab emtansine
      D09980  Trastuzumab emtansine (USAN/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D09980  Trastuzumab emtansine (USAN/INN); Trastuzumab emtansine (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   EGFR family
    ERBB2 (HER2, CD340) [HSA_VAR:2064v1 2064v3]
     D09980  Trastuzumab emtansine (USAN/INN) <JP/US>
 Not elsewhere classified
  Cellular components
   Cytoskeleton
    TUBB
     D09980  Trastuzumab emtansine (USAN/INN) <JP/US>
Antineoplastics [br08340.html]
 D09980
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D09980
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09980
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D09980
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09980
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Companion diagnostics
  D09980
BRITE hierarchy
Other DBs
CAS: 1018448-65-1
PubChem: 135626701

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