KEGG   DRUG: D10062Help
Entry
D10062                      Drug                                   

Name
Cabozantinib (USAN)
Formula
C28H24FN3O5
Exact mass
501.17
Mol weight
501.5057
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antineoplastic
Comment
medullary thyroid carcinoma
Target
PDGFRA tyrosine kinase inhibitor [HSA:5156] [KO:K04363];
PDGFRB tyrosine kinase inhibitor [HSA:5159] [KO:K05089];
RET inhibitor [HSA:5979] [KO:K05126];
VEGFR1 tyrosine kinase inhibitor [HSA:2321] [KO:K05096];
VEGFR2 tyrosine kinase inhibitor [HSA:3791] [KO:K05098];
VEGFR3 tyrosine kinase inhibitor [HSA:2324] [KO:K05097];
c-KIT tyrosine kinase inhibitor [HSA:3815] [KO:K05091]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04370  VEGF signaling pathway
hsa05200  Pathways in cancer  
 
Brite
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Cabozantinib
    D10062  Cabozantinib (USAN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class III (PDGF receptor family)
    PDGFRA tyrosine kinase [HSA:5156] [KO:K04363]
     Cabozantinib
      D10062  Cabozantinib (USAN)
    PDGFRB tyrosine kinase [HSA:5159] [KO:K05089]
     Cabozantinib
      D10062  Cabozantinib (USAN)
    c-KIT tyrosine kinase [HSA:3815] [KO:K05091]
     Cabozantinib
      D10062  Cabozantinib (USAN)
   RTK class V (VEGF receptor family)
    VEGFR1 tyrosine kinase [HSA:2321] [KO:K05096]
     Cabozantinib
      D10062  Cabozantinib (USAN)
    VEGFR2 tyrosine kinase [HSA:3791] [KO:K05098]
     Cabozantinib
      D10062  Cabozantinib (USAN)
    VEGFR3 tyrosine kinase [HSA:2324] [KO:K05097]
     Cabozantinib
      D10062  Cabozantinib (USAN)
   RTK class XIV (RET receptor family)
    RET [HSA:5979] [KO:K05126] [EC:2.7.10.1]
     Cabozantinib
      D10062  Cabozantinib (USAN)
BRITE hierarchy
Other DBs
CAS: 
849217-68-1
PubChem: 
LigandBox: 
KCF data Show

ATOM        37
            1   C8y C    16.3800  -12.0400
            2   C8y C    16.3800  -13.4400
            3   C8y C    15.1900  -14.1400
            4   C8x C    13.9300  -13.4400
            5   C8x C    13.9300  -12.0400
            6   N5x N    15.1900  -11.3400
            7   C8x C    17.5700  -11.3400
            8   C8y C    18.8300  -12.0400
            9   C8y C    18.8300  -13.4400
            10  C8x C    17.5700  -14.1400
            11  O2a O    20.0200  -11.3400
            12  C1a C    21.2100  -12.0400
            13  O2a O    20.0200  -14.1400
            14  C1a C    21.2100  -13.4400
            15  O2a O    15.1900  -15.5400
            16  C8y C    16.4500  -16.2400
            17  C8x C    16.4500  -17.6400
            18  C8x C    17.6400  -18.3400
            19  C8y C    18.8300  -17.6400
            20  C8x C    18.8300  -16.1700
            21  C8x C    17.6400  -15.4700
            22  N1b N    20.0900  -18.2700
            23  C5a C    21.2800  -17.5700
            24  C1z C    22.5400  -18.2700
            25  O5a O    21.2800  -16.1700
            26  C5a C    23.7300  -17.5000
            27  N1b N    24.9200  -18.2000
            28  O5a O    23.7300  -16.1000
            29  C8y C    26.1100  -17.5000
            30  C8x C    27.3700  -18.2000
            31  C8x C    28.4900  -17.4300
            32  C8y C    28.4900  -16.0300
            33  C8x C    27.3000  -15.4000
            34  C8x C    26.1100  -16.1000
            35  X   F    29.7500  -15.4000
            36  C1x C    21.8400  -19.4600
            37  C1x C    23.2400  -19.4600
BOND        41
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    2  10 1
            12    8  11 1
            13   11  12 1
            14    9  13 1
            15   13  14 1
            16    3  15 1
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   16  21 1
            24   19  22 1
            25   22  23 1
            26   23  24 1
            27   23  25 2
            28   24  26 1
            29   26  27 1
            30   26  28 2
            31   27  29 1
            32   29  30 2
            33   30  31 1
            34   31  32 2
            35   32  33 1
            36   33  34 2
            37   29  34 1
            38   32  35 1
            39   36  37 1
            40   37  24 1
            41   24  36 1

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