KEGG   DRUG: D10071Help
Entry
D10071                      Drug                                   

Name
Ixekizumab (USAN)
Sequence
(A chain)
QVQLVQSGAE VKKPGSSVKV SCKASGYSFT DYHIHWVRQA PGQGLEWMGV INPMYGTTDY
NQRFKGRVTI TADESTSTAY MELSSLRSED TAVYYCARYD YFTGTGVYWG QGTLVTVSSA
STKGPSVFPL APCSRSTSES TAALGCLVKD YFPEPVTVSW NSGALTSGVH TFPAVLQSSG
LYSLSSVVTV PSSSLGTKTY TCNVDHKPSN TKVDKRVESK YGPPCPPCPA PEFLGGPSVF
LFPPKPKDTL MISRTPEVTC VVVDVSQEDP EVQFNWYVDG VEVHNAKTKP REEQFNSTYR
VVSVLTVLHQ DWLNGKEYKC KVSNKGLPSS IEKTISKAKG QPREPQVYTL PPSQEEMTKN
QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSRLT VDKSRWQEGN
VFSCSVMHEA LHNHYTQKSL SLSLG
(B chain)
DIVMTQTPLS LSVTPGQPAS ISCRSSRSLV HSRGNTYLHW YLQKPGQSPQ LLIYKVSNRF
IGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCSQSTHLP FTFGQGTKLE IKRTVAAPSV
FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ SGNSQESVTE QDSKDSTYSL
SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(dimer; disulfide bridge: A22-A96, A133-B219, A146-A202, A225-A'225, A228-A'228, A260-A320, A366-A424, A'22-A'96, A'133-B'219, A'146-A'202, A'260-A'320, A'366-A'424, B23-B'93, B139-B199, B'23-B'93, B'139-B'199)
  Type
Peptide
Activity
Treatment of autoimmune diseases
Comment
Monoclonal antibody
Target
interleukin 17 receptor [HSA:23765] [KO:K05164]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  IL-17 receptor family
   interleukin 17 receptor [HSA:23765] [KO:K05164]
    Ixekizumab
     D10071  Ixekizumab (USAN)
BRITE hierarchy
Other DBs
PubChem: 

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