KEGG   DRUG: IxekizumabHelp
Entry
D10071                      Drug                                   

Name
Ixekizumab (USAN);
Ixekizumab (genetical recombination) (JAN)
Product
Sequence
(A chain)
QVQLVQSGAE VKKPGSSVKV SCKASGYSFT DYHIHWVRQA PGQGLEWMGV INPMYGTTDY
NQRFKGRVTI TADESTSTAY MELSSLRSED TAVYYCARYD YFTGTGVYWG QGTLVTVSSA
STKGPSVFPL APCSRSTSES TAALGCLVKD YFPEPVTVSW NSGALTSGVH TFPAVLQSSG
LYSLSSVVTV PSSSLGTKTY TCNVDHKPSN TKVDKRVESK YGPPCPPCPA PEFLGGPSVF
LFPPKPKDTL MISRTPEVTC VVVDVSQEDP EVQFNWYVDG VEVHNAKTKP REEQFNSTYR
VVSVLTVLHQ DWLNGKEYKC KVSNKGLPSS IEKTISKAKG QPREPQVYTL PPSQEEMTKN
QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSRLT VDKSRWQEGN
VFSCSVMHEA LHNHYTQKSL SLSLG
(B chain)
DIVMTQTPLS LSVTPGQPAS ISCRSSRSLV HSRGNTYLHW YLQKPGQSPQ LLIYKVSNRF
IGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCSQSTHLP FTFGQGTKLE IKRTVAAPSV
FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ SGNSQESVTE QDSKDSTYSL
SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(dimer; disulfide bridge: A22-A96, A133-B219, A146-A202, A225-A'225, A228-A'228, A260-A320, A366-A424, A'22-A'96, A'133-B'219, A'146-A'202, A'260-A'320, A'366-A'424, B23-B'93, B139-B199, B'23-B'93, B'139-B'199)
  Type
Peptide
Remark
Therapeutic category: 
Activity
Treatment of autoimmune diseases
Comment
Monoclonal antibody
Target
interleukin 17 receptor [HSA:23765] [KO:K05164]
  Pathway
Cytokine-cytokine receptor interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D10071  Ixekizumab (USAN); Ixekizumab (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  IL-17 receptor family
   interleukin 17 receptor
    Ixekizumab
     D10071  Ixekizumab (USAN)
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D10071
BRITE hierarchy
Other DBs
PubChem: 

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