KEGG   DRUG: D10075Help
Entry
D10075                      Drug                                   

Name
Navarixin (USAN);
Navarixin hydrate
Formula
C21H23N3O5. H2O
Exact mass
415.1743
Mol weight
415.4397
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of asthma and COPD
Target
chemokine (C-X-C motif) receptor 2 (CRCX2) antagonist [HSA:3579] [KO:K05050];
chemokine (C-X-C motif) receptor 1 (CRCX1) antagonist [HSA:3577] [KO:K04175]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04062  Chemokine signaling pathway  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Chemokine receptors
   chemokine receptor 1 (CXCR1)
    Navarixin
     D10075  Navarixin (USAN)
   chemokine receptor 2 (CXCR2)
    Navarixin
     D10075  Navarixin (USAN)
BRITE hierarchy
Other DBs
PubChem: 
LigandBox: 
KCF data Show

ATOM        30
            1   C8x C    11.5500  -14.9100
            2   C8y C    11.5500  -16.3100
            3   C8y C    12.7400  -17.0100
            4   C8y C    14.0000  -16.3100
            5   C8x C    14.0000  -14.9100
            6   C8x C    12.7400  -14.2100
            7   C5a C    10.2900  -17.0100
            8   N1c N     9.1000  -16.3100
            9   O5a O    10.2900  -18.4100
            10  C1a C     7.9100  -17.0100
            11  C1a C     9.1000  -14.9100
            12  O1a O    12.7400  -18.4100
            13  N1b N    15.1900  -17.0100
            14  C2y C    16.3800  -16.3100
            15  C2y C    17.7800  -16.3100
            16  C5x C    17.7800  -14.9800
            17  C5x C    16.3800  -14.9800
            18  N1b N    18.9700  -17.0100
            19  C1c C    20.1600  -16.3100
            20  O5x O    18.7600  -14.0000
            21  O5x O    15.4000  -14.0000
            22  C8y C    21.3500  -17.0100
            23  C1b C    20.1600  -14.9100
            24  C1a C    21.3500  -14.2100
            25  C8x C    21.7700  -18.3400
            26  C8x C    23.2400  -18.3400
            27  C8y C    23.6600  -17.0100
            28  O2x O    22.5400  -16.1700
            29  C1a C    24.9900  -16.5900
            30  O0  O    25.8300  -13.9300
BOND        31
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     2   7 1
            8     7   8 1
            9     7   9 2
            10    8  10 1
            11    8  11 1
            12    3  12 1
            13    4  13 1
            14   13  14 1
            15   14  15 2
            16   15  16 1
            17   16  17 1
            18   14  17 1
            19   15  18 1
            20   18  19 1
            21   16  20 2
            22   17  21 2
            23   19  22 1
            24   19  23 1 #Down
            25   23  24 1
            26   22  25 2
            27   25  26 1
            28   26  27 2
            29   27  28 1
            30   22  28 1
            31   27  29 1

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