KEGG   DRUG: D10080Help
Entry
D10080                      Drug                                   

Name
Sirukumab (USAN)
Formula
C6450H9926N1690O1998S46
Exact mass
144497.421
Mol weight
144586.9416
Sequence
(A chain)
EVQLVESGGG LVQPGGSLRL SCAASGFTFS PFAMSWVRQA PGKGLEWVAK ISPGGSWTYY
SDTVTGRFTI SRDNAKNSLY LQMNSLRAED TAVYYCARQL WGYYALDIWG QGTTVTVSSA
STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW NSGALTSGVH TFPAVLQSSG
LYSLSSVVTV PSSSLGTQTY ICNVNHKPSN TKVDKKVEPK SCDKTHTCPP CPAPELLGGP
SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS
TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSRDEL
TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ
QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
(B chain)
EIVLTQSPAT LSLSPGERAT LSCSASISVS YMYWYQQKPG QAPRLLIYDM SNLASGIPAR
FSGSGSGTDF TLTISSLEPE DFAVYYCMQW SGYPYTFGGG TKVEIKRTVA APSVFIFPPS
DEQLKSGTAS VVCLLNNFYP REAKVQWKVD NALQSGNSQE SVTEQDSKDS TYSLSSTLTL
SKADYEKHKV YACEVTHQGL SSPVTKSFNR GEC
(dimer; disulfide bridge: A22-A96, A146-A202, A222-B213, A228-A'228, A231-A'231, A263-A323, A369-A427, A'22-A'96, A'146-A'202, A'222-B'213, A'263-A'323, A'369-A'427, B23-B87, B133-B193, B'23-B'87, B'13-B'193)
  Type
Peptide
Activity
Treatment of rheumatoid arthritis
Comment
Monoclonal antibody
Target
IL-6 [HSA:3569] [KO:K05405]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  Jak-STAT signaling pathway  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines
  Class I cytokines
   IL-6
    Sirukumab
     D10080  Sirukumab (USAN)
BRITE hierarchy
Other DBs
PubChem: 

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