KEGG   DRUG: SirukumabHelp
Entry
D10080                      Drug                                   

Name
Sirukumab (USAN);
Sirukumab (genetical recombination) (JAN)
Formula
C6450H9926N1690O1998S46
Exact mass
144497.421
Mol weight
144586.9416
Sequence
(A chain)
EVQLVESGGG LVQPGGSLRL SCAASGFTFS PFAMSWVRQA PGKGLEWVAK ISPGGSWTYY
SDTVTGRFTI SRDNAKNSLY LQMNSLRAED TAVYYCARQL WGYYALDIWG QGTTVTVSSA
STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW NSGALTSGVH TFPAVLQSSG
LYSLSSVVTV PSSSLGTQTY ICNVNHKPSN TKVDKKVEPK SCDKTHTCPP CPAPELLGGP
SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS
TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSRDEL
TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ
QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
(B chain)
EIVLTQSPAT LSLSPGERAT LSCSASISVS YMYWYQQKPG QAPRLLIYDM SNLASGIPAR
FSGSGSGTDF TLTISSLEPE DFAVYYCMQW SGYPYTFGGG TKVEIKRTVA APSVFIFPPS
DEQLKSGTAS VVCLLNNFYP REAKVQWKVD NALQSGNSQE SVTEQDSKDS TYSLSSTLTL
SKADYEKHKV YACEVTHQGL SSPVTKSFNR GEC
(dimer; disulfide bridge: A22-A96, A146-A202, A222-B213, A228-A'228, A231-A'231, A263-A323, A369-A427, A'22-A'96, A'146-A'202, A'222-B'213, A'263-A'323, A'369-A'427, B23-B87, B133-B193, B'23-B'87, B'13-B'193)
  Type
Peptide
Class
Other
 DG02019  Interleukin inhibitor
Remark
ATC code: 
Efficacy
Antirheumatic, Anti-IL-6 antibody
Comment
Monoclonal antibody
Treatment of rheumatoid arthritis
Target
IL6 [HSA:3569] [KO:K05405]
  Pathway
Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AC Interleukin inhibitors
     L04AC15 Sirukumab
      D10080  Sirukumab (USAN)
Target-based classification of drugs [BR:br08310]
 Cytokines
  Class I cytokines
   interleukin 6
    Sirukumab
     D10080  Sirukumab (USAN)
BRITE hierarchy
Other DBs
CAS: 
1194585-53-9
PubChem: 

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