KEGG   DRUG: D10083Help
Entry
D10083                      Drug                                   

Name
Tabalumab (USAN)
Formula
C6518H10008N1724O2032S38
Exact mass
146160.2177
Mol weight
146250.0077
Sequence
(A chain)
QVQLQQWGAG LLKPSETLSL TCAVYGGSFS GYYWSWIRQP PGKGLEWIGE INHSGSTNYN
PSLKSRVTIS VDTSKNQFSL KLSSVTAADT AVYYCARGYY DILTGYYYYF DYWGQGTLVT
VSSASTKGPS VFPLAPCSRS TSESTAALGC LVKDYFPEPV TVSWNSGALT SGVHTFPAVL
QSSGLYSLSS VVTVPSSSLG TKTYTCNVDH KPSNTKVDKR VESKYGPPCP PCPAPEFLGG
PSVFLFPPKP KDTLMISRTP EVTCVVVDVS QEDPEVQFNW YVDGVEVHNA KTKPREEQFN
STYRVVSVLT VLHQDWLNGK EYKCKVSNKG LPSSIEKTIS KAKGQPREPQ VYTLPPSQEE
MTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SRLTVDKSRW
QEGNVFSCSV MHEALHNHYT QKSLSLSLGK
(Bchain)
EIVLTQSPAT LSLSPGERAT LSCRASQSVS RYLAWYQQKP GQAPRLLIYD ASNRATGIPA
RFSGSGSGTD STLTISSLEP EDFAVYYCQQ RSNWPRTFGQ GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSNTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(dimer; disulfide bridge: A22-A95, A137-B214, A150-206, A229-A'229, A232-A'232, A264-A324, A370-A428, A'22-A'95, A'137-B'214, A'150-A'206, A'264-A'324, A'370-A'428, B23-B88, B134-B194, B'23-B'88, B'134-B'194)
  Type
Peptide
Activity
Autoimmune diseases and B cell malignancies
Comment
Monoclonal antibody
Target
BLyS (BAFF) [HSA:10673] [KO:K05476]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines
  TNF family
   BAFF
    Tabalumab
     D10083  Tabalumab (USAN)
BRITE hierarchy
Other DBs
PubChem: 

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