KEGG   DRUG: D10088Help
Entry
D10088                      Drug                                   

Name
Amitifadine (USAN)
Formula
C11H11Cl2N
Exact mass
227.0269
Mol weight
228.1177
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of depression
Target
serotonin transporter inhibitor [HSA:6532] [KO:K05037];
noradrenalin transporter inhibitor [HSA:6530] [KO:K05035];
dopamine transporter inhibitor [HSA:6531] [KO:K05036]
  Pathway
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse  
 
Brite
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (noradrenalin transporter)
     Amitifadine
      D10088  Amitifadine (USAN)
    SLC6A3 (dopamine transporter)
     Amitifadine
      D10088  Amitifadine (USAN)
    SLC6A4 (serotonin transporter)
     Amitifadine
      D10088  Amitifadine (USAN)
BRITE hierarchy
Other DBs
CAS: 
410074-73-6
PubChem: 
LigandBox: 
KCF data Show

ATOM        14
            1   C8x C    24.0800  -17.8500
            2   C8y C    24.0800  -19.2500
            3   C8y C    22.8900  -19.9500
            4   C8x C    21.6300  -19.2500
            5   C8y C    21.6300  -17.8500
            6   C8x C    22.8900  -17.1500
            7   X   Cl   22.8900  -21.3500
            8   X   Cl   25.2700  -19.9500
            9   C1z C    20.4400  -17.1500
            10  C1y C    19.0400  -17.1500
            11  C1x C    19.7400  -18.3400
            12  C1x C    20.8600  -15.8200
            13  N1x N    19.7400  -14.9800
            14  C1x C    18.5500  -15.8200
BOND        16
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     3   7 1
            8     2   8 1
            9     9   5 1 #Up
            10    9  10 1
            11   10  11 1
            12   11   9 1
            13    9  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1

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