KEGG   DRUG: D10089Help
Entry
D10089                      Drug                                   

Name
Amitifadine hydrochloride (USAN)
Formula
C11H11Cl2N. HCl
Exact mass
263.0035
Mol weight
264.5787
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of depression
Target
serotonin transporter inhibitor [HSA:6532] [KO:K05037];
noradrenalin transporter inhibitor [HSA:6530] [KO:K05035];
dopamine transporter inhibitor [HSA:6531] [KO:K05036]
  Pathway
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse  
 
Brite
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (noradrenalin transporter) [HSA:6530] [KO:K05035]
     Amitifadine
      D10089  Amitifadine hydrochloride (USAN)
    SLC6A3 (dopamine transporter) [HSA:6531] [KO:K05036]
     Amitifadine
      D10089  Amitifadine hydrochloride (USAN)
    SLC6A4 (serotonin transporter) [HSA:6532] [KO:K05037]
     Amitifadine
      D10089  Amitifadine hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 
410074-74-7
PubChem: 
LigandBox: 
KCF data Show

ATOM        15
            1   C8x C    27.0200  -20.8600
            2   C8y C    27.0200  -22.2600
            3   C8y C    25.8300  -22.9600
            4   C8x C    24.5700  -22.2600
            5   C8y C    24.5700  -20.8600
            6   C8x C    25.8300  -20.1600
            7   X   Cl   25.8300  -24.3600
            8   X   Cl   28.2100  -22.9600
            9   C1z C    23.3800  -20.1600
            10  C1y C    21.9800  -20.1600
            11  C1x C    22.6800  -21.3500
            12  C1x C    23.8000  -18.8300
            13  N1x N    22.6800  -17.9900
            14  C1x C    21.4900  -18.8300
            15  X   Cl   28.3500  -18.2700
BOND        16
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     3   7 1
            8     2   8 1
            9     9   5 1 #Up
            10    9  10 1
            11   10  11 1
            12   11   9 1
            13    9  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1

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