KEGG   DRUG: D10151Help
Entry
D10151                      Drug                                   

Name
Plazomicin (USAN)
Formula
C25H48N6O10
Exact mass
592.3432
Mol weight
592.6828
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of gram-negative bacterial infections
Remark
Drug group: 
Comment
Semisynthetic derivative of Sisomicin [DR:D02544]
Aminoglycosides
Target
16S rRNA of 30S ribosomal subunit, protein synthesis inhibitor [KO:K01977]
  Pathway
ko03010  Ribosome  
 
Interaction
Drug interaction
Brite
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   16S rRNA of 30S ribosomal subunit inhibitor
    Aminoglycosides
     Plazomicin
      D10151  Plazomicin (USAN)
BRITE hierarchy
Other DBs
CAS: 
1154757-24-0
PubChem: 
LigandBox: 
KCF data Show

ATOM        41
            1   C1x C    18.3400  -25.8300
            2   C1z C    18.3400  -27.2300
            3   C1y C    19.5524  -27.9300
            4   C1y C    20.7649  -27.2300
            5   C1y C    20.7649  -25.8300
            6   O2x O    19.5524  -25.1300
            7   O2a O    21.9960  -25.1190
            8   O1a O    21.9960  -27.9410
            9   N1b N    19.5524  -29.3298
            10  O1a O    16.9400  -27.2300
            11  C1a C    17.6400  -28.4424
            12  C1a C    18.3232  -30.0397
            13  C1y C    23.2084  -24.4190
            14  C1y C    24.4492  -25.1355
            15  C1x C    25.6617  -24.4356
            16  C1y C    25.6619  -23.0356
            17  C1y C    24.4211  -22.3191
            18  C1y C    23.2086  -23.0190
            19  N1b N    24.4490  -26.5299
            20  O1a O    22.0246  -22.3351
            21  N1a N    26.8978  -22.3220
            22  C5a C    25.6471  -27.2219
            23  C1c C    26.8358  -26.5358
            24  O5a O    25.6470  -28.6297
            25  C1b C    28.0262  -27.2234
            26  O1a O    26.8361  -25.1302
            27  C1b C    29.2162  -26.5366
            28  N1a N    30.4060  -27.2238
            29  O2a O    24.4213  -20.9300
            30  C1y C    25.6404  -20.2264
            31  O2x O    26.8389  -20.9188
            32  C2y C    28.0515  -20.2191
            33  C2x C    28.0518  -18.8191
            34  C1x C    26.8533  -18.1267
            35  C1y C    25.6407  -18.8264
            36  N1a N    24.4146  -18.1180
            37  C1b C    29.2824  -20.9301
            38  N1b N    29.2821  -22.3298
            39  C1b C    30.4778  -23.0206
            40  C1b C    31.6654  -22.3352
            41  O1a O    32.8563  -23.0232
BOND        43
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     5   7 1 #Down
            8     4   8 1 #Down
            9     3   9 1 #Up
            10    2  10 1 #Up
            11    2  11 1 #Down
            12    9  12 1
            13   13   7 1 #Down
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   13  18 1
            20   14  19 1 #Up
            21   18  20 1 #Up
            22   16  21 1 #Up
            23   19  22 1
            24   22  23 1
            25   22  24 2
            26   23  25 1
            27   23  26 1 #Up
            28   25  27 1
            29   27  28 1
            30   17  29 1 #Down
            31   30  29 1 #Down
            32   30  31 1
            33   31  32 1
            34   32  33 2
            35   33  34 1
            36   34  35 1
            37   30  35 1
            38   35  36 1 #Down
            39   32  37 1
            40   37  38 1
            41   38  39 1
            42   39  40 1
            43   40  41 1

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