KEGG   DRUG: D10184Help
Entry
D10184                      Drug                                   

Name
Vortioxetine (USAN)
Formula
C18H22N2S
Exact mass
298.1504
Mol weight
298.4457
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidepressant, anxiolytic
Remark
ATC code: 
Drug group: 
Target
5-HT3-receptor antagonist [HSA:3359 9177 170572 200909 285242] [KO:K04819];
5-HT7-receptor antagonist [HSA:3363] [KO:K04163];
5-HT1A-receptor agonist [HSA:3350] [KO:K04153]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse  
 
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX26 Vortioxetine
      D10184  Vortioxetine (USAN)
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Vortioxetine
    D10184  Vortioxetine (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    5-HT1A-receptor
     Vortioxetine
      D10184  Vortioxetine (USAN)
    5-HT3-receptor
     Vortioxetine
      D10184  Vortioxetine (USAN)
    5-HT7-receptor
     Vortioxetine
      D10184  Vortioxetine (USAN)
BRITE hierarchy
Other DBs
CAS: 
508233-74-7
PubChem: 
LigandBox: 
KCF data Show

ATOM        21
            1   C8x C    16.6600  -18.2000
            2   C8x C    16.6600  -19.6000
            3   C8y C    17.8724  -20.3000
            4   C8y C    19.0849  -19.6000
            5   C8x C    19.0849  -18.2000
            6   C8x C    17.8724  -17.5000
            7   S2a S    17.8724  -21.6998
            8   C8y C    16.6432  -22.4097
            9   C8x C    15.4392  -21.7146
            10  C8x C    14.2268  -22.4146
            11  C8y C    14.2269  -23.8146
            12  C8x C    15.4308  -24.5097
            13  C8y C    16.6432  -23.8097
            14  C1a C    13.0083  -24.5183
            15  C1a C    17.8639  -24.5145
            16  N1y N    20.3160  -20.3110
            17  C1x C    20.3157  -21.6999
            18  C1x C    21.5280  -22.4002
            19  N1x N    22.7406  -21.7005
            20  C1x C    22.7409  -20.3116
            21  C1x C    21.5286  -19.6113
BOND        23
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     3   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15   11  14 1
            16   13  15 1
            17    4  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   20  21 1
            23   16  21 1

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