KEGG   DRUG: D10185Help
Entry
D10185                      Drug                                   

Name
Vortioxetine hydrobromide (JAN/USAN)
Product
Formula
C18H22N2S. HBr
Exact mass
378.0765
Mol weight
379.3576
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidepressant, anxiolytic
Remark
ATC code: 
Drug group: 
Target
5-HT3-receptor antagonist [HSA:3359 9177 170572 200909 285242] [KO:K04819];
5-HT7-receptor antagonist [HSA:3363] [KO:K04163];
5-HT1A-receptor agonist [HSA:3350] [KO:K04153]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse  
 
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX26 Vortioxetine
      D10185  Vortioxetine hydrobromide (USAN)
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Vortioxetine
    D10185  Vortioxetine hydrobromide (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    5-HT1A-receptor
     Vortioxetine
      D10185  Vortioxetine hydrobromide (USAN)
    5-HT3-receptor
     Vortioxetine
      D10185  Vortioxetine hydrobromide (USAN)
    5-HT7-receptor
     Vortioxetine
      D10185  Vortioxetine hydrobromide (USAN)
BRITE hierarchy
Other DBs
CAS: 
960203-27-4
PubChem: 
LigandBox: 
KCF data Show

ATOM        22
            1   C8x C    21.8400  -20.0200
            2   C8x C    21.8400  -21.4200
            3   C8y C    23.0300  -22.1200
            4   C8y C    24.2900  -21.4200
            5   C8x C    24.2900  -20.0200
            6   C8x C    23.0300  -19.3200
            7   S2a S    23.0300  -23.5200
            8   C8y C    21.8400  -24.2200
            9   C8x C    20.5800  -23.5200
            10  C8x C    19.3900  -24.2200
            11  C8y C    19.3900  -25.6200
            12  C8x C    20.5800  -26.3200
            13  C8y C    21.8400  -25.6200
            14  C1a C    18.2000  -26.3200
            15  C1a C    23.0300  -26.3200
            16  N1y N    25.4800  -22.1200
            17  C1x C    25.4800  -23.5200
            18  C1x C    26.6700  -24.2200
            19  N1x N    27.9300  -23.5200
            20  C1x C    27.9300  -22.1200
            21  C1x C    26.6700  -21.4200
            22  X   Br   28.7000  -26.8100
BOND        23
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     3   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15   11  14 1
            16   13  15 1
            17    4  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   20  21 1
            23   16  21 1

» Japanese version   » Back

DBGET integrated database retrieval system