KEGG   DRUG: D10190Help
Entry
D10190                      Drug                                   

Name
Tivozanib hydrochloride (USAN);
Tivozanib hydrochloride monohydrate
Formula
C22H19ClN4O5. HCl. H2O
Exact mass
508.0916
Mol weight
509.3393
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of solid tumor
Remark
Drug group: 
Comment
Angiogenesis inhibitor
Target
VEGFR1 tyrosine kinase inhibitor [HSA:2321] [KO:K05096];
VEGFR2 tyrosine kinase inhibitor [HSA:3791] [KO:K05098];
VEGFR3 tyrosine kinase inhibitor [HSA:2324] [KO:K05097]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04370  VEGF signaling pathway  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class V (VEGF receptor family)
    VEGFR1 tyrosine kinase
     Tivozanib
      D10190  Tivozanib hydrochloride (USAN)
    VEGFR2 tyrosine kinase
     Tivozanib
      D10190  Tivozanib hydrochloride (USAN)
    VEGFR3 tyrosine kinase
     Tivozanib
      D10190  Tivozanib hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 
682745-41-1
PubChem: 
LigandBox: 
KCF data Show

ATOM        34
            1   C8y C    17.0800  -19.3200
            2   C8y C    17.0800  -20.7200
            3   C8x C    18.3400  -21.4200
            4   C8y C    19.5300  -20.7200
            5   C8y C    19.5300  -19.3200
            6   C8x C    18.3400  -18.6200
            7   C8y C    20.7200  -21.4200
            8   C8x C    21.9800  -20.7200
            9   C8x C    21.9800  -19.3200
            10  N5x N    20.7200  -18.6200
            11  O2a O    20.7200  -22.8200
            12  C8y C    21.9800  -23.5200
            13  O2a O    15.8900  -18.6200
            14  C1a C    14.7000  -19.2500
            15  O2a O    15.8900  -21.4200
            16  C1a C    14.7000  -20.7200
            17  C8x C    21.9800  -24.9200
            18  C8y C    23.1700  -25.6200
            19  C8y C    24.3600  -24.9200
            20  C8x C    24.3600  -23.5200
            21  C8x C    23.1700  -22.8200
            22  N1b N    25.6200  -25.6200
            23  C5a C    26.8100  -24.9200
            24  N1b N    28.0000  -25.6200
            25  C8y C    29.1900  -24.9200
            26  O5a O    26.8100  -23.5200
            27  X   Cl   23.1700  -27.0200
            28  C8x C    29.1900  -23.5200
            29  N5x N    30.5200  -25.3400
            30  O2x O    31.3600  -24.2200
            31  C8y C    30.5200  -23.0300
            32  C1a C    30.9400  -21.7700
            33  X   Cl   26.1800  -18.8300
            34  O0  O    29.4000  -18.8300
BOND        35
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12    7  11 1
            13   11  12 1
            14    1  13 1
            15   13  14 1
            16    2  15 1
            17   15  16 1
            18   12  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   12  21 1
            24   19  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   23  26 2
            29   18  27 1
            30   25  28 1
            31   25  29 2
            32   29  30 1
            33   30  31 1
            34   28  31 2
            35   31  32 1

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