KEGG   DRUG: D10224Help
Entry
D10224                      Drug                                   

Name
Golvatinib (USAN)
Formula
C33H37F2N7O4
Exact mass
633.2875
Mol weight
633.6882
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antineoplastic
Target
met proto-oncogene (c-Met) inhibitor [HSA:4233] [KO:K05099];
VEGFR2 tyrosine kinase inhibitor [HSA:3791] [KO:K05098]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04151  PI3K-Akt signaling pathway
hsa04370  VEGF signaling pathway  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class V (VEGF receptor family)
    VEGFR2 tyrosine kinase [HSA:3791] [KO:K05098]
     Golvatinib
      D10224  Golvatinib (USAN)
 Protein kinases
  Tyrosine protein kinases
   Met family
    MET [HSA:4233] [KO:K05099]
     Golvatinib
      D10224  Golvatinib (USAN)
BRITE hierarchy
Other DBs
CAS: 
928037-13-2
PubChem: 
KCF data Show

ATOM        46
            1   N1y N     4.9700  -11.3400
            2   C1x C     4.9700  -12.7400
            3   C1x C     6.1600  -13.4400
            4   N1y N     7.4200  -12.7400
            5   C1x C     7.4200  -11.3400
            6   C1x C     6.1600  -10.6400
            7   C1a C     3.7800  -10.6400
            8   C1y C     8.6100  -13.4400
            9   C1x C     8.6100  -14.8400
            10  C1x C     9.8700  -15.5400
            11  N1y N    11.0600  -14.8400
            12  C1x C    11.0600  -13.4400
            13  C1x C     9.8700  -12.7400
            14  C5a C    12.2500  -15.5400
            15  N1b N    13.4400  -14.8400
            16  O5a O    12.2500  -16.9400
            17  C8y C    14.6300  -15.5400
            18  N5x N    14.6300  -16.9400
            19  C8x C    15.8900  -17.6400
            20  C8x C    17.0800  -16.9400
            21  C8y C    17.0800  -15.5400
            22  C8x C    15.8900  -14.8400
            23  O2a O    18.2700  -14.8400
            24  C8y C    19.4600  -15.5400
            25  C8x C    19.4600  -16.9400
            26  C8y C    20.7200  -17.6400
            27  C8y C    21.9100  -16.9400
            28  C8x C    21.9100  -15.5400
            29  C8x C    20.7200  -14.8400
            30  N1b N    23.1000  -17.6400
            31  C5a C    24.2900  -16.9400
            32  C1z C    25.4800  -17.6400
            33  O5a O    24.2900  -15.5400
            34  C5a C    26.6700  -16.9400
            35  N1b N    27.8600  -17.6400
            36  O5a O    26.6700  -15.5400
            37  C8y C    29.0500  -16.9400
            38  C8x C    30.2400  -17.6400
            39  C8x C    31.5000  -16.9400
            40  C8y C    31.5000  -15.5400
            41  C8x C    30.3100  -14.8400
            42  C8x C    29.0500  -15.5400
            43  X   F    32.6900  -14.8400
            44  C1x C    24.7800  -18.8300
            45  C1x C    26.1800  -18.8300
            46  X   F    20.7372  -19.0399
BOND        51
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1
            8     4   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    8  13 1
            15   11  14 1
            16   14  15 1
            17   14  16 2
            18   15  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 2
            22   20  21 1
            23   21  22 2
            24   17  22 1
            25   21  23 1
            26   23  24 1
            27   24  25 2
            28   25  26 1
            29   26  27 2
            30   27  28 1
            31   28  29 2
            32   24  29 1
            33   27  30 1
            34   30  31 1
            35   31  32 1
            36   31  33 2
            37   32  34 1
            38   34  35 1
            39   34  36 2
            40   35  37 1
            41   37  38 2
            42   38  39 1
            43   39  40 2
            44   40  41 1
            45   41  42 2
            46   37  42 1
            47   40  43 1
            48   44  45 1
            49   45  32 1
            50   44  32 1
            51   26  46 1

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