KEGG   DRUG: GolvatinibHelp
Entry
D10224                      Drug                                   

Name
Golvatinib (USAN)
Formula
C33H37F2N7O4
Exact mass
633.2875
Mol weight
633.6882
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Remark
Chemical group: 
Activity
Antineoplastic
Target
MET [HSA:4233] [KO:K05099];
VEGFR2 (KDR) [HSA:3791] [KO:K05098]
  Pathway
Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
VEGF signaling pathway
Interaction
Drug interaction
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class V (VEGF receptor family)
    VEGFR2 tyrosine kinase
     Golvatinib
      D10224  Golvatinib (USAN)
 Protein kinases
  Tyrosine protein kinases
   Met family
    MET
     Golvatinib
      D10224  Golvatinib (USAN)
BRITE hierarchy
Other DBs
CAS: 
928037-13-2
PubChem: 
PDB-CCD: 
KCF data Show

ATOM        46
            1   N1y N     4.9700  -11.3400
            2   C1x C     4.9700  -12.7400
            3   C1x C     6.1600  -13.4400
            4   N1y N     7.4200  -12.7400
            5   C1x C     7.4200  -11.3400
            6   C1x C     6.1600  -10.6400
            7   C1a C     3.7800  -10.6400
            8   C1y C     8.6100  -13.4400
            9   C1x C     8.6100  -14.8400
            10  C1x C     9.8700  -15.5400
            11  N1y N    11.0600  -14.8400
            12  C1x C    11.0600  -13.4400
            13  C1x C     9.8700  -12.7400
            14  C5a C    12.2500  -15.5400
            15  N1b N    13.4400  -14.8400
            16  O5a O    12.2500  -16.9400
            17  C8y C    14.6300  -15.5400
            18  N5x N    14.6300  -16.9400
            19  C8x C    15.8900  -17.6400
            20  C8x C    17.0800  -16.9400
            21  C8y C    17.0800  -15.5400
            22  C8x C    15.8900  -14.8400
            23  O2a O    18.2700  -14.8400
            24  C8y C    19.4600  -15.5400
            25  C8x C    19.4600  -16.9400
            26  C8y C    20.7200  -17.6400
            27  C8y C    21.9100  -16.9400
            28  C8x C    21.9100  -15.5400
            29  C8x C    20.7200  -14.8400
            30  N1b N    23.1000  -17.6400
            31  C5a C    24.2900  -16.9400
            32  C1z C    25.4800  -17.6400
            33  O5a O    24.2900  -15.5400
            34  C5a C    26.6700  -16.9400
            35  N1b N    27.8600  -17.6400
            36  O5a O    26.6700  -15.5400
            37  C8y C    29.0500  -16.9400
            38  C8x C    30.2400  -17.6400
            39  C8x C    31.5000  -16.9400
            40  C8y C    31.5000  -15.5400
            41  C8x C    30.3100  -14.8400
            42  C8x C    29.0500  -15.5400
            43  X   F    32.6900  -14.8400
            44  C1x C    24.7800  -18.8300
            45  C1x C    26.1800  -18.8300
            46  X   F    20.7372  -19.0399
BOND        51
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1
            8     4   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    8  13 1
            15   11  14 1
            16   14  15 1
            17   14  16 2
            18   15  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 2
            22   20  21 1
            23   21  22 2
            24   17  22 1
            25   21  23 1
            26   23  24 1
            27   24  25 2
            28   25  26 1
            29   26  27 2
            30   27  28 1
            31   28  29 2
            32   24  29 1
            33   27  30 1
            34   30  31 1
            35   31  32 1
            36   31  33 2
            37   32  34 1
            38   34  35 1
            39   34  36 2
            40   35  37 1
            41   37  38 2
            42   38  39 1
            43   39  40 2
            44   40  41 1
            45   41  42 2
            46   37  42 1
            47   40  43 1
            48   44  45 1
            49   45  32 1
            50   44  32 1
            51   26  46 1

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