KEGG   DRUG: D10229Help
Entry
D10229                      Drug                                   
Name
Masitinib (INN)
Formula
C28H30N6OS
Exact mass
498.2202
Mol weight
498.6424
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antineoplastic [veterinary]
Remark
ATC code: 
Target
c-KIT tyrosine kinase inhibitor [HSA:3815] [KO:K05091]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04151  PI3K-Akt signaling pathway  
 
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XE Protein kinase inhibitors
     L01XE22 Masitinib
      D10229  Masitinib (INN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class III (PDGF receptor family)
    c-KIT tyrosine kinase [HSA:3815] [KO:K05091]
     Masitinib [ATC:L01XE22]
      D10229  Masitinib (INN)
BRITE hierarchy
Other DBs
CAS: 
790299-79-5
PubChem: 
KCF data Show

ATOM        36
            1   C8x C     8.2600  -13.7200
            2   C8x C     8.2600  -15.1200
            3   C8x C     9.4500  -15.8200
            4   C8y C    10.7100  -15.1200
            5   C8x C    10.7100  -13.7200
            6   N5x N     9.4500  -13.0200
            7   C8y C    11.9000  -15.8200
            8   C8x C    12.3200  -17.1500
            9   S2x S    13.7200  -17.1500
            10  C8y C    14.1400  -15.8200
            11  N5x N    13.0200  -14.9800
            12  N1b N    15.3300  -15.1200
            13  C8y C    16.5200  -15.8200
            14  C8y C    16.5086  -17.2200
            15  C8x C    17.7153  -17.9298
            16  C8x C    18.9334  -17.2397
            17  C8y C    18.8748  -15.8397
            18  C8x C    17.7381  -15.1299
            19  N1b N    20.1121  -15.1195
            20  C5a C    21.3105  -15.8059
            21  C1a C    15.2992  -17.9052
            22  C8y C    22.4915  -15.1185
            23  O5a O    21.2457  -17.2195
            24  C8x C    23.6907  -15.8054
            25  C8x C    24.9008  -15.1013
            26  C8y C    24.8961  -13.7013
            27  C8x C    23.6969  -13.0144
            28  C8x C    22.4868  -13.7185
            29  C1b C    26.1155  -12.9915
            30  N1y N    27.3384  -13.6916
            31  C1x C    27.3430  -15.1197
            32  C1x C    28.5577  -15.8158
            33  N1y N    29.7679  -15.1119
            34  C1x C    29.7633  -13.6838
            35  C1x C    28.5486  -12.9877
            36  C1a C    30.9724  -15.8024
BOND        40
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 1
            11   10  11 2
            12   11   7 1
            13   12  13 1
            14   12  10 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   13  18 1
            21   17  19 1
            22   19  20 1
            23   14  21 1
            24   20  22 1
            25   20  23 2
            26   22  24 2
            27   24  25 1
            28   25  26 2
            29   26  27 1
            30   27  28 2
            31   22  28 1
            32   26  29 1
            33   29  30 1
            34   30  31 1
            35   31  32 1
            36   32  33 1
            37   33  34 1
            38   34  35 1
            39   30  35 1
            40   33  36 1

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