KEGG   DRUG: ImgatuzumabHelp
Entry
D10439                      Drug                                   

Name
Imgatuzumab (USAN/INN)
Formula
C6434H9942N1718O2016S44
Exact mass
144937.5966
Mol weight
145026.9443
Sequence
(Heavy chain)
QVQLVQSGAE VKKPGSSVKV SCKASGFTFT DYKIHWVRQA PGQGLEWMGY FNPNSGYSTY
AQKFQGRVTI TADKSTSTAY MELSSLRSED TAVYYCARLS PGGYYVMDAW GQGTTVTVSS
ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS
GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKKVEP KSCDKTHTCP PCPAPELLGG
PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN
STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE
LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW
QQGNVFSCSV MHEALHNHYT QKSLSLSPG
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCRASQGIN NYLNWYQQKP GKAPKRLIYN TNNLQTGVPS
RFSGSGSGTE FTLTISSLQP EDFATYYCLQ HNSFPTFGQG TKLEIKRTVA APSVFIFPPS
DEQLKSGTAS VVCLLNNFYP REAKVQWKVD NALQSGNSQE SVTEQDSKDS TYSLSSTLTL
SKADYEKHKV YACEVTHQGL SSPVTKSFNR GEC
(dimer)
(disulfide bridges: H22-H96, H147-H203, H223-L213, H229-H'229, H232-H'232, H264-H324, H370-H428, H'22-H'96, H'147-H'203, H'223-L'213, H'264-H'324, H'370-H'428, L23-L88, L133-L'193, L'23-L'88, L'133-L'193)
(glycosylation site: H300, H'300)
  Type
Peptide
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Activity
Antineoplastic, Anti-epidermal growth factor receptor antibody
Interaction
Drug interaction
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class I (EGF receptor family)
    EGFR tyrosine kinase
     Imgatuzumab
      D10439  Imgatuzumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
959963-46-3
PubChem: 

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