KEGG   DRUG: D10486Help
Entry
D10486                      Drug                                   

Name
Pimasertib hydrochloride (USAN)
Formula
C15H15FIN3O3. HCl
Exact mass
466.9909
Mol weight
467.6617
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antineoplastic
Target
MEK1/2 inhibitor [HSA:5604 5605] [KO:K04368 K04369]
  Pathway
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04370  VEGF signaling pathway
hsa05200  Pathways in cancer  
 
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Serine/threonine protein kinases: STE group
   STE7 family
    MEK1/2 [HSA:5604 5605] [KO:K04368 K04369]
     Pimasertib
      D10486  Pimasertib hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 
1236361-78-6
PubChem: 
KCF data Show

ATOM        24
            1   C8x C    18.6200  -13.9300
            2   C8x C    18.6200  -15.3300
            3   C8y C    19.8800  -16.0300
            4   C8y C    21.0700  -15.3300
            5   C8x C    21.0700  -13.9300
            6   C8y C    19.8800  -13.2300
            7   X   I    19.8800  -11.8300
            8   N1b N    19.8800  -17.4300
            9   C8y C    18.6200  -18.2000
            10  C8x C    17.4300  -17.5000
            11  N5x N    16.2400  -18.2000
            12  C8x C    16.2400  -19.6000
            13  C8x C    17.4300  -20.3000
            14  C8y C    18.6200  -19.6000
            15  C5a C    19.8800  -20.3000
            16  N1b N    21.0700  -19.6000
            17  C1b C    22.2600  -20.3000
            18  C1c C    23.4500  -19.6000
            19  C1b C    24.6400  -20.2300
            20  O1a O    25.8300  -19.6000
            21  O5a O    19.8800  -21.7000
            22  X   F    22.3300  -16.1000
            23  O1a O    23.4500  -18.1300
            24  X   Cl   28.0700  -15.1900
BOND        24
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     3   8 1
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15    9  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   15  21 2
            23    4  22 1
            24   18  23 1 #Down

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