KEGG   DRUG: イブプロフェンHelp
エントリ  
D00126                      Drug                                   

一般名   
イブプロフェン (JP17);
Ibuprofen (JP17/USP/INN)
商品名   
  後発品
米国の商品 
  後発品
IBU (DIRECT RX), IBU (DIRECT RX), IBU (RedPharm Drug), IBU (RedPharm Drug), IBU (RedPharm Drug), IBUPROFEN (A-S Medication Solutions), IBUPROFEN (A-S Medication Solutions), IBUPROFEN (Actavis Pharma), IBUPROFEN (AiPing Pharmaceutical), IBUPROFEN (AiPing Pharmaceutical), IBUPROFEN (Aidarex Pharmaceuticals LLC), ALIVIO (Alivio Medical Products), ALIVIO (Alivio Medical Products), ALIVIO (Alivio Medical Products), IBUPROFEN (Altura Pharmaceuticals), IBUPROFEN (American Health Packaging), IBUPROFEN (Amneal Pharmaceuticals of New York), IBUPROFEN (Amneal Pharmaceuticals of New York), IBUPROFEN (Aphena Pharma Solutions - Tennessee), IBUPROFEN (Aphena Pharma Solutions - Tennessee), IBUPROFEN (Apotheca), IBUPROFEN (Apotheca), IBUPROFEN (Ascend Laboratories), IBUPROFEN (Ascend Laboratories), IBUPROFEN (Ascend Laboratories), IBUPROFEN (Ascend Laboratories), IBUPROFEN (AvKARE), IBUPROFEN (Bi-Coastal Pharma International LLC), IBUPROFEN (Biomes Pharmaceuticals LLC), IBUPROFEN (Biomes Pharmaceuticals LLC), IBUPROFEN (Biomes Pharmaceuticals LLC), IBUPROFEN (Blenheim Pharmacal), IBU (Blenheim Pharmacal), IBUPROFEN (Blenheim Pharmacal), IBUPROFEN (Blenheim Pharmacal), IBUPROFEN (Blenheim Pharmacal), IBUPROFEN (Blenheim Pharmacal), IBUPROFEN (Blenheim Pharmacal), IBUPROFEN (Blenheim Pharmacal), IBUPROFEN (Blenheim Pharmacal), IBUPROFEN (Bryant Ranch Prepack), IBU (Bryant Ranch Prepack), IBUPROFEN (Bryant Ranch Prepack), IBUPROFEN (Bryant Ranch Prepack), IBUPROFEN (Bryant Ranch Prepack), IBU (Cardinal Health), IBUPROFEN (Cardinal Health), IBUPROFEN (Cardinal Health), IBUPROFEN (Cardinal Health), IBUPROFEN (Cardinal Health), IBUPROFEN (Cardinal Health), IBUPROFEN (Contract Pharmacy Services-PA), IBUPROFEN (Contract Pharmacy Services-PA), IBUPROFEN (Contract Pharmacy Services-PA), IBUPROFEN (Contract Pharmacy Services-PA), IBUPROFEN (Contract Pharmacy Services-PA), IBUPROFEN (Contract Pharmacy Services-PA), IBUPROFEN (Denton Pharma), IBUPROFEN (Direct Rx), IBUPROFEN (DirectRX), IBUPROFEN (Dispensing Solutions), IBUPROFEN (Dispensing Solutions), IBU (Dr. Reddy's Laboratories Limited), IBUPROFEN (Golden State Medical Supply), IBU (Golden State Medical Supply), IBUPROFEN (H.J. Harkins Company), IBUPROFEN (H.J. Harkins Company), IBUPROFEN (HHS/Program Support Center/Supply Service Center), IBUPROFEN (Hi-Tech Pharmacal), IBUPROFEN (Ingenus Pharmaceuticals), IBU (KAISER FOUNDATION HOSPITALS), IBUPROFEN (KAISER FOUNDATION HOSPITALS), IBUPROFEN (Keltman Pharmaceuticals), IBUPROFEN (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), IBUPROFEN (Lake Erie Medical DBA Quality Care Products LLC), IBU (Lake Erie Medical DBA Quality Care Products LLC), IBU (Lake Erie Medical DBA Quality Care Products LLC), IBUPROFEN (Lake Erie Medical DBA Quality Care Products LLC), IBUPROFEN (Lake Erie Medical DBA Quality Care Products LLC), IBUPROFEN (Legacy Pharmaceutical Packaging), IBUPROFEN (Legacy Pharmaceutical Packaging), IBUPROFEN (Life Line Home Care Services), IBUPROFEN (MARKSANS PHARMA LIMITED), IBUPROFEN (Major Pharmaceuticals), IBUPROFEN (Major Pharmaceuticals), IBUPROFEN (Mas Management Group), IBUPROFEN (McKesson Contract Packaging), IBUPROFEN (McKesson Packaging Serivces a business unit of McKesson Corporation), IBUPROFEN (Med Health Pharma), IBUPROFEN (MedVantx), IBUPROFEN (Medsource Pharmaceuticals), IBUPROFEN (Medsource Pharmaceuticals), IBUPROFEN (Method Pharmaceuticals), IBUPROFEN (NCS HealthCare of KY), IBUPROFEN (Northwind Pharmaceuticals), IBUPROFEN (Northwind Pharmaceuticals), IBUPROFEN (Northwind Pharmaceuticals), IBUPROFEN (Northwind Pharmaceuticals), IBUPROFEN (Northwind Pharmaceuticals), IBU (NuCare Pharmaceuticals), IBU (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBU (NuCare Pharmaceuticals), IBU (NuCare Pharmaceuticals), IBU (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBU (NuCare Pharmaceuticals), IBU (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBU (NuCare Pharmaceuticals), IBU (NuCare Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), COMFORT PAC WITH IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (Perrigo New York), PERRIGO IBUPROFEN (Perrigo Pharmaceuticals Company), IBUPROFEN (Perrigo Pharmaceuticals Company), IBUPROFEN (Pharmaceutical Associates), IBUPROFEN (Physicians Total Care), IBUPROFEN (Polygen Pharmaceuticals LLC), IBUPROFEN (Preferred Pharmaceuticals), IBUPROFEN (Preferred Pharmaceuticals), IBUPROFEN (Preferred Pharmaceuticals), IBUPROFEN (Preferred Pharmaceuticals), IBUPROFEN (Preferred Pharmaceuticals), IBUPROFEN (Proficient Rx LP), IBU (Proficient Rx LP), IBUPROFEN (Proficient Rx LP), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (Rebel Distributors Corp), IBUPROFEN (Rebel Distributors Corp), IBUPROFEN (Rebel Distributors Corp), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (RxChange), IBUPROFEN (RxChange), IBUPROFEN (STAT RX USA LLC), IBUPROFEN (STAT Rx USA LLC), IBUPROFEN (STAT Rx USA LLC), IBUPROFEN (Shasun Pharmaceuticals Limited), IBUPROFEN (St Marys Medical Park Pharmacy), IBUPROFEN (State of Florida DOH Central Pharmacy), IBUPROFEN (State of Florida DOH Central Pharmacy), IBUPROFEN (TIME CAP LABORATORIES), IBUPROFEN (TYA Pharmaceuticals), IBUPROFEN (Taro Pharmaceuticals U.S.A.), IBUPROFEN (Unit Dose Services), IBUPROFEN (Unit Dose Services), IBUPROFEN (Unit Dose Services), IBU (Unit Dose Services), IBU (Unit Dose Services), IBU (Unit Dose Services), IBUPROFEN (Unit Dose Services), IBU (Unit Dose Services), IBUPROFEN (VistaPharm)
  その他
組成式   
C13H18O2
質量    
206.1307
分子量   
206.2808
構造式   
Mol fileKCF fileDB searchJmolKegDraw
Simcomp    SIMCOMP
クラス   
抗炎症薬
 DG01908  プロピオン酸系抗炎症薬
 DG01504  非ステロイド性抗炎症薬 (NSAID)
  DG01908  プロピオン酸系抗炎症薬
コード   
同一コード: C01588
薬効分類: 1149
ATCコード: C01EB16 G02CC01 M01AE01 M02AA13 R02AX02
Chemical グループ: DG00245
効能    
鎮痛薬, 抗炎症薬, 解熱薬, シクロオキシゲナーゼ阻害薬
  疾患
関節リウマチ [DS:H00630]
神経炎 [DS:H01638]
コメント  
プロピオン酸誘導体
適応症:関節リウマチ, 関節痛及び関節炎, 神経痛及び神経炎, 背腰痛, 頚腕症候群, 子宮付属器炎, 月経困難症, 紅斑 (結節性紅斑, 多形滲出性紅斑, 遠心性環状紅斑) 並びに症状の消炎・鎮痛; 手術並びに外傷後の消炎・鎮痛; 急性上気道炎 (急性気管支炎を伴う急性上気道炎を含む) の解熱・鎮痛
ターゲット 
PTGS1 (COX1) [HSA:5742] [KO:K00509];
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  パスウェイ
アラキドン酸の代謝
VEGF シグナル伝達経路
代謝    
Enzyme: CYP2C9 [HSA:1559]
相互作用  
Drug interaction
構造マップ 
抗片頭痛薬
シクロオキシナーゼ (COX) 阻害薬
階層分類  
医療用医薬品の薬効分類 [BR:jp08301]
 1  神経系及び感覚器官用医薬品
  11  中枢神経系用薬
   114  解熱鎮痛消炎剤
    1149  その他の解熱鎮痛消炎剤
     D00126  イブプロフェン (JP17)
医療用医薬品のATC分類 [BR:jp08303]
 C 循環器系
  C01 心疾患治療
   C01E その他の心疾患用製剤
    C01EB その他の心疾患用製剤
     C01EB16 イブプロフェン
      D00126  イブプロフェン (JP17)
 G 泌尿生殖器系と性ホルモン
  G02 その他の婦人科用薬
   G02C その他の婦人科用薬
    G02CC 膣内投与用抗炎症製剤
     G02CC01 イブプロフェン
      D00126  イブプロフェン (JP17)
 M 筋骨格系
  M01 抗炎症及び抗リウマチ製剤
   M01A 抗炎症及び抗リウマチ製剤、非ステロイド系
    M01AE プロピオン酸誘導体
     M01AE01 イブプロフェン
      D00126  イブプロフェン (JP17)
  M02 関節・筋肉痛用局所薬剤
   M02A 関節・筋肉痛用局所薬剤
    M02AA 抗炎症製剤、局所用非ステロイド系
     M02AA13 イブプロフェン
      D00126  イブプロフェン (JP17)
 R 呼吸器系
  R02 咽頭用製剤
   R02A 咽頭用製剤
    R02AX その他の咽頭用製剤
     R02AX02 イブプロフェン
      D00126  イブプロフェン (JP17)
医療用医薬品のUSP分類 [BR:jp08302]
 鎮痛薬
  非ステロイド系抗炎症薬
   イブプロフェン
    D00126  イブプロフェン (JP17)
 抗炎症薬
  非ステロイド系抗炎症薬
   イブプロフェン
    D00126  イブプロフェン (JP17)
一般用医薬品の分類 [BR:jp08313]
 精神神経用薬
  01 かぜ薬(内用)
   D00126  イブプロフェン (JP17)
  03 解熱鎮痛薬
   D00126  イブプロフェン (JP17)
一般用医薬品のリスク区分 [BR:jp08312]
 指定第二類
  無機薬品及び有機薬品
   イブプロフェン
    D00126  イブプロフェン (JP17)
 第二類
  無機薬品及び有機薬品
   イブプロフェン
    D00126  イブプロフェン (JP17)
ターゲットに基づく医薬品分類 [BR:jp08310]
 酵素
  酸化還元酵素
   シクロオキシナーゼ-1 (COX-1)
    イブプロフェン
     D00126  イブプロフェン (JP17)
   シクロオキシナーゼ-2 (COX-2)
    イブプロフェン
     D00126  イブプロフェン (JP17)
チトクローム P450 の相互作用 [BR:jp08309]
 CYP基質
  CYP2C9
   イブプロフェン
    D00126  イブプロフェン (JP17)
 トランスポーター阻害薬
  OAT2
   イブプロフェン
    D00126  イブプロフェン (JP17)
日本薬局方収載医薬品 [BR:jp08311]
 化学薬品等
  D00126  イブプロフェン
リウマチ・痛風治療薬 [jp08366.html]
 リウマチ治療薬
  D00126
麻酔薬・鎮痛薬と抗炎症薬 [jp08369.html]
 消炎鎮痛薬
  D00126
日本のスイッチOTC薬 [jp08314.html]
 医療用から一般用へのスイッチOTC薬
  D00126
BRITE hierarchy
リンク   
CAS: 
15687-27-1
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
日化辞: 

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