KEGG   DRUG: D00304Help
エントリ  
D00304                      Drug                                   

一般名   
ジバルプロエクスナトリウム;
バルプロ酸セミナトリウム;
Divalproex sodium (USP);
Valproate semisodium (INN)
米国の商品 
  後発品
DIVALPROEX SODIUM (Aidarex Pharmaceuticals LLC), DIVALPROEX SODIUMDELAYED-RELEASE (Aidarex Pharmaceuticals LLC), DIVALPROEX SODIUM (American Health Packaging), DIVALPROEX SODIUM (American Health Packaging), DIVALPROEX SODIUM (American Health Packaging), DIVALPROEX SODIUM (Aphena Pharma Solutions - Tennessee), DIVALPROEX SODIUM (Aurobindo Pharma Limited), DIVALPROEX SODIUM (Aurobindo Pharma Limited), DIVALPROEX SODIUM (BluePoint Laboratories), DIVALPROEX SODIUM (Bryant Ranch Prepack), DIVALPROEX SODIUM (Bryant Ranch Prepack), DIVALPROEX SODIUM (Bryant Ranch Prepack), DIVALPROEX SODIUM (Cadila Healthcare Limited), DIVALPROEX SODIUM (Cadila Healthcare Limited), DIVALPROEX SODIUM (Cadila Healthcare Limited), DIVALPROEX SODIUM (Cardinal Health), DIVALPROEX SODIUM (Cardinal Health), DIVALPROEX SODIUM (Cardinal Health), DIVALPROEX SODIUM (Cardinal Health), DIVALPROEX SODIUM (Cardinal Health), DIVALPROEX SODIUM (Cardinal Health), DIVALPROEX SODIUM (Carilion Materials Management), DIVALPROEX SODIUM (Citron Pharma LLC), DIVALPROEX SODIUM (Clinical Solutions Wholesale), DIVALPROEX SODIUM (Contract Pharmacy Services-PA), DIVALPROEX SODIUM (Contract Pharmacy Services-PA), DIVALPROEX SODIUM (Dr. Reddy's Laboratories), DIVALPROEX SODIUM (Dr. Reddy's Laboratories), DIVALPROEX SODIUM (Dr. Reddy's Laboratories), DIVALPROEX SODIUM (Dr. Reddy's Laboratories), DIVALPROEX SODIUM (Global Pharmaceuticals), DIVALPROEX SODIUM (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), DIVALPROEX SODIUM (Lake Erie Medical DBA Quality Care Products LLC), DIVALPROEX SODIUM (Lupin Pharmaceuticals), DIVALPROEX SODIUM (Major Pharmaceuticals), DIVALPROEX SODIUM (McKesson Contract Packaging), DIVALPROEX SODIUM (McKesson Contract Packaging), DIVALPROEX SODIUM (McKesson Contract Packaging), DIVALPROEX SODIUM (McKesson Packaging Services a business unit of McKesson Corporation), DIVALPROEX SODIUM (Mylan Institutional), DIVALPROEX SODIUM (Mylan Institutional), DIVALPROEX SODIUM (Mylan Institutional), DIVALPROEX SODIUM (Mylan Pharmaceutical), DIVALPROEX SODIUM (Mylan Pharmaceuticals), DIVALPROEX SODIUM (Mylan Pharmaceuticals), DIVALPROEX SODIUM (NCS HealthCare of KY), DIVALPROEX SODIUM (NCS HealthCare of KY), DIVALPROEX SODIUM (NCS HealthCare of KY), DIVALPROEX SODIUM (PD-Rx Pharmaceuticals), DIVALPROEX SODIUM (Par Pharmaceutical), DIVALPROEX SODIUM (Physicians Total Care), DIVALPROEX SODIUM (Physicians Total Care), DIVALPROEX SODIUM (Qualitest Pharmaceuticals), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUMDELAYED-RELEASE (REMEDYREPACK), DIVALPROEX SODIUM (Rebel Distributors Corp), DIVALPROEX SODIUM (STAT RX USA LLC), DIVALPROEX SODIUM (State of Florida DOH Central Pharmacy), DIVALPROEX SODIUM (State of Florida DOH Central Pharmacy), DIVALPROEX SODIUM (State of Florida DOH Central Pharmacy), DIVALPROEX SODIUM (State of Florida DOH Central Pharmacy), DIVALPROEX SODIUM (State of Florida DOH Central Pharmacy), DIVALPROEX SODIUM (Sun Pharmaceutical Industries Limited), DIVALPROEX SODIUM (TWi Pharmaceuticals), DIVALPROEX SODIUM (TYA Pharmaceuticals), DIVALPROEX SODIUM EXTENDED-RELEASE (TYA Pharmaceuticals), DIVALPROEX SODIUM (TYA Pharmaceuticals), DIVALPROEX SODIUM (Teva Pharmaceuticals USA), DIVALPROEX SODIUM (Unichem Pharmaceuticals (USA)), DIVALPROEX SODIUM (Unit Dose Services), DIVALPROEX SODIUM (Upsher-Smith Laboratories), DIVALPROEX SODIUM (Upsher-Smith Laboratories), DIVALPROEX SODIUM (WOCKHARDT LIMITED), DIVALPROEX SODIUM (WOCKHARDT LIMITED), DIVALPROEX SODIUM (WOCKHARDT USA LLC), DIVALPROEX SODIUM (WOCKHARDT USA LLC), DIVALPROEX SODIUM (Watson Pharma), DIVALPROEX SODIUM (Zydus Pharmaceuticals (USA)), DIVALPROEX SODIUM (Zydus Pharmaceuticals (USA)), DIVALPROEX SODIUM (Zydus Pharmaceuticals (USA)), DIVALPROEX SODIUM EXTENDED-RELEASE (Zydus Pharmaceuticals USA), DIVALPROEX SODIUM DELAYED RELEASE (REMEDYREPACK), DIVALPROEX SODIUM DELAYED RELEASE (REMEDYREPACK), DIVALPROEX SODIUM EXTENDED RELEASE (REMEDYREPACK), DIVALPROEX SODIUM EXTENDED-RELEASE (American Health Packaging), DIVALPROEX SODIUM EXTENDED-RELEASE (Cardinal Health)
組成式   
(C8H15O2. Na)n. (C8H16O2)m
構造式   
Mol fileKCF fileDB searchJmolKegDraw
効能    
抗てんかん薬
コード   
ATCコード: N03AG01
医薬品グループ: DG00849
コメント  
バルプロ酸は尿素サイクル異常症 [DS:H00164 H00185 H00186 H00187 H01028 H01032] の患者には禁忌である。
ターゲット 
GABA transaminase inhibitor [HSA:18] [KO:K13524];
calcium channel T type blocker [HSA:8911 8912 8913] [KO:K04856 K04855 K04854];
histone acetyltransferase inhibitor [HSA:203611 253175 9085 9426] [KO:K00653];
histone deacetylases (HDACs) inhibitor [HSA:3065 3066 8841 9759 10014 10013 51564 55869 9734 83933] [KO:K06067 K11404 K11406 K11407 K11408 K11405 K11409]
  パスウェイ
hsa04010  MAPK シグナル伝達経路
hsa04020  カルシウムシグナル伝達経路
hsa04727  GABA作動性シナプス  
 
代謝    
Enzyme: CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
相互作用  
Genomic biomarker: (1) NAGS [HSA:162417], CPS [HSA:1373], ASS [HSA:445], OTC [HSA:5009], ASL [HSA:435], ARG [HSA:383 384], (2) POLG [HSA:5428]
Drug interaction
構造マップ 
抗痙攣薬
カルシウムチャネル遮断薬
抗片頭痛薬
階層分類  
医療用医薬品のATC分類 [BR:jp08303]
 N 神経系
  N03 抗てんかん薬
   N03A 抗てんかん薬
    N03AG 脂肪酸誘導体
     N03AG01 バルプロ酸
      D00304  ジバルプロエクスナトリウム
医療用医薬品のUSP分類 [BR:jp08302]
 抗けいれん薬
  ガンマアミノ酪酸(GABA)増強剤
   ジバルプロエクス
    D00304  ジバルプロエクスナトリウム
   バルプロ酸
    D00304  ジバルプロエクスナトリウム
 抗片頭痛薬
  予防薬
   ジバルプロエクス
    D00304  ジバルプロエクスナトリウム
 双極性障害治療薬
  気分安定薬
   ジバルプロエクス
    D00304  ジバルプロエクスナトリウム
ターゲットに基づく医薬品分類 [BR:jp08310]
 イオンチャネル
  電位開口型カチオンチャネル
   カルシウムチャネル, CACN alpha-1, CaVx.x
    カルシウムチャネルT型
     バルプロ酸
      D00304  ジバルプロエクスナトリウム
 酵素
  転移酵素
   ヒストンアセチルトランスフェラーゼ
    バルプロ酸
     D00304  ジバルプロエクスナトリウム
   GABAトランスアミナーゼ
    バルプロ酸
     D00304  ジバルプロエクスナトリウム
  加水分解酵素
   ヒストンデアセチラーゼ
    バルプロ酸
     D00304  ジバルプロエクスナトリウム
チトクローム P450 の相互作用 [BR:jp08309]
 基質
  CYP2C9
   バルプロ酸
    D00304  ジバルプロエクスナトリウム
BRITE hierarchy
リンク   
CAS: 
76584-70-8
PubChem: 
DrugBank: 
LigandBox: 

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