KEGG   DRUG: ジバルプロエクスナトリウムHelp
エントリ  
D00304                      Drug                                   

一般名   
ジバルプロエクスナトリウム;
バルプロ酸セミナトリウム;
Divalproex sodium (USP);
Valproate semisodium (INN)
米国の商品 
  後発品
DIVALPROEX SODIUM (Aidarex Pharmaceuticals LLC), DIVALPROEX SODIUMDELAYED-RELEASE (Aidarex Pharmaceuticals LLC), DIVALPROEX SODIUM (American Health Packaging), DIVALPROEX SODIUM (American Health Packaging), DIVALPROEX SODIUM (American Health Packaging), DIVALPROEX SODIUM (American Health Packaging), DIVALPROEX SODIUM (Amneal Pharmaceuticals LLC), DIVALPROEX SODIUM (Aphena Pharma Solutions - Tennessee), DIVALPROEX SODIUM (Aphena Pharma Solutions - Tennessee), DIVALPROEX SODIUM (Aphena Pharma Solutions - Tennessee), DIVALPROEX SODIUM (Aphena Pharma Solutions - Tennessee), DIVALPROEX SODIUM (Aurobindo Pharma Limited), DIVALPROEX SODIUM (Aurobindo Pharma Limited), DIVALPROEX SODIUM (AvPAK), DIVALPROEX SODIUM (Avera McKennan Hospital), DIVALPROEX SODIUM (Avera McKennan Hospital), DIVALPROEX SODIUM (Avera McKennan Hospital), DIVALPROEX SODIUM (Avera McKennan Hospital), DIVALPROEX SODIUM (Avera McKennan Hospital), DIVALPROEX SODIUM (BluePoint Laboratories), DIVALPROEX SODIUM (Bryant Ranch Prepack), DIVALPROEX SODIUM (Bryant Ranch Prepack), DIVALPROEX SODIUM (Bryant Ranch Prepack), DIVALPROEX SODIUM (Bryant Ranch Prepack), DIVALPROEX SODIUM (Cadila Healthcare Limited), DIVALPROEX SODIUM (Cadila Healthcare Limited), DIVALPROEX SODIUM (Cadila Healthcare Limited), DIVALPROEX SODIUM (Cardinal Health), DIVALPROEX SODIUM (Cardinal Health), DIVALPROEX SODIUM (Cardinal Health), DIVALPROEX SODIUM (Cardinal Health), DIVALPROEX SODIUM (Cardinal Health), DIVALPROEX SODIUM (Carilion Materials Management), DIVALPROEX SODIUM (Carilion Materials Management), DIVALPROEX SODIUM (Clinical Solutions Wholesale), DIVALPROEX SODIUM (Contract Pharmacy Services-PA), DIVALPROEX SODIUM (Contract Pharmacy Services-PA), DIVALPROEX SODIUM (Contract Pharmacy Services-PA), DIVALPROEX SODIUM (Contract Pharmacy Services-PA), DIVALPROEX SODIUM (Contract Pharmacy Services-PA), DIVALPROEX SODIUM (Contract Pharmacy Services-PA), DIVALPROEX SODIUM (Contract Pharmacy Services-PA), DIVALPROEX SODIUM (Contract Pharmacy Services-PA), DIVALPROEX SODIUM (Contract Pharmacy Services-PA), DIVALPROEX SODIUM (DIRECT RX), DIVALPROEX SODIUM (DIRECT RX), DIVALPROEX SODIUM (DirectRX), DIVALPROEX SODIUM (Dr. Reddy's Laboratories), DIVALPROEX SODIUM (Dr. Reddy's Laboratories), DIVALPROEX SODIUM (Dr. Reddy's Laboratories), DIVALPROEX SODIUM (Dr. Reddy's Laboratories), DIVALPROEX SODIUM (Impax Generics), DIVALPROEX SODIUM (Lupin Pharmaceuticals), DIVALPROEX SODIUM (Major Pharmaceuticals), DIVALPROEX SODIUM (Major Pharmaceuticals), DIVALPROEX SODIUM (Medsource Pharmaceuticals), DIVALPROEX SODIUM (Mylan Institutional), DIVALPROEX SODIUM (Mylan Pharmaceuticals), DIVALPROEX SODIUM (NCS HealthCare of KY), DIVALPROEX SODIUM (NCS HealthCare of KY), DIVALPROEX SODIUM (NCS HealthCare of KY), DIVALPROEX SODIUM (NCS HealthCare of KY), DIVALPROEX SODIUM (NCS HealthCare of KY), DIVALPROEX SODIUM (NCS HealthCare of KY), DIVALPROEX SODIUM (NorthStar Rx LLC), DIVALPROEX SODIUM (NuCare Pharmaceuticals), DIVALPROEX SODIUM (PD-Rx Pharmaceuticals), DIVALPROEX SODIUM (Par Pharmaceutical), DIVALPROEX SODIUM (Physicians Total Care), DIVALPROEX SODIUM (Physicians Total Care), DIVALPROEX SODIUM (Proficient Rx LP), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (Rebel Distributors Corp), DIVALPROEX SODIUM (Rising Health), DIVALPROEX SODIUM (Sandoz), DIVALPROEX SODIUM EXTENDED-RELEASE (State of Florida DOH Central Pharmacy), DIVALPROEX SODIUM (State of Florida DOH Central Pharmacy), DIVALPROEX SODIUM (State of Florida DOH Central Pharmacy), DIVALPROEX SODIUM (State of Florida DOH Central Pharmacy), DIVALPROEX SODIUM (State of Florida DOH Central Pharmacy), DIVALPROEX SODIUM (State of Florida DOH Central Pharmacy), DIVALPROEX SODIUM (State of Florida DOH Central Pharmacy), DIVALPROEX SODIUM (State of Florida DOH Central Pharmacy), DIVALPROEX SODIUM (State of Florida DOH Central Pharmacy), DIVALPROEX SODIUM (Sun Pharmaceutical Industries Limited), DIVALPROEX SODIUM (TYA Pharmaceuticals), DIVALPROEX SODIUM EXTENDED-RELEASE (TYA Pharmaceuticals), DIVALPROEX SODIUM (TYA Pharmaceuticals), DIVALPROEX SODIUM (Teva Pharmaceuticals USA), DIVALPROEX SODIUM (Unichem Pharmaceuticals (USA)), DIVALPROEX SODIUM (Unit Dose Services), DIVALPROEX SODIUM (Upsher-Smith Laboratories), DIVALPROEX SODIUM (WOCKHARDT LIMITED), DIVALPROEX SODIUM (WOCKHARDT LIMITED), DIVALPROEX SODIUM (Wockhardt USA LLC.), DIVALPROEX SODIUM (Wockhardt USA LLC.), DIVALPROEX SODIUM (Zydus Pharmaceuticals (USA)), DIVALPROEX SODIUM (Zydus Pharmaceuticals (USA)), DIVALPROEX SODIUM (Zydus Pharmaceuticals (USA)), DIVALPROEX SODIUM (Zydus Pharmaceuticals USA)
組成式   
(C8H15O2. Na)n. (C8H16O2)m
構造式   
Mol fileKCF fileDB searchJmolKegDraw
Simcomp    SIMCOMP
クラス   
精神神経系用薬
 DG02035  脂肪酸系抗てんかん薬
その他
 DG01575  カルシウムチャネル遮断薬
  DG01573  カルシウムチャネルT型遮断薬
Cyp 基質
 DG01633  CYP3Aにより代謝される薬剤
コード   
ATCコード: N03AG01
化学構造グループ: DG00849
商品 (DG00849): D00399<US> D00304<US> D00710<JP/US>
効能    
抗けいれん薬
コメント  
脂肪酸誘導体
バルプロ酸は尿素サイクル異常症 [DS:H00164 H00185 H00186 H00187 H01028 H01032] の患者には禁忌である。
ターゲット 
ABAT [HSA:18] [KO:K13524]
SSADH [HSA:7915] [KO:K00139]
GAD [HSA:2571 2572] [KO:K01580]
CACNA1-T [HSA:8911 8912 8913] [KO:K04856 K04855 K04854]
  パスウェイ
hsa04020  カルシウムシグナル伝達経路
hsa04727  GABA作動性シナプス
相互作用  
Drug interaction
構造マップ 
map07033  抗痙攣薬
map07036  カルシウムチャネル遮断薬
map07048  抗片頭痛薬
階層分類  
医療用医薬品のATC分類 [BR:jp08303]
 N 神経系
  N03 抗てんかん薬
   N03A 抗てんかん薬
    N03AG 脂肪酸誘導体
     N03AG01 バルプロ酸
      D00304  ジバルプロエクスナトリウム <US>
医療用医薬品のUSP分類 [BR:jp08302]
 抗けいれん薬
  ガンマアミノ酪酸(GABA)増強剤
   ジバルプロエクス
    D00304  ジバルプロエクスナトリウム
   バルプロ酸
    D00304  ジバルプロエクスナトリウム
 抗片頭痛薬
  予防薬
   ジバルプロエクス
    D00304  ジバルプロエクスナトリウム
   バルプロ酸
    D00304  ジバルプロエクスナトリウム
 双極性障害治療薬
  気分安定薬
   ジバルプロエクス
    D00304  ジバルプロエクスナトリウム
   バルプロ酸
    D00304  ジバルプロエクスナトリウム
Target-based classification of drugs  [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Calcium channels
    CACNA1-T
     D00304  Divalproex sodium (USP) <US>
 Enzymes
  Oxidoreductases (EC1)
   Dehydrogenases
    SSADH
     D00304  Divalproex sodium (USP) <US>
  Transferases (EC2)
   Aminotransferase
    ABAT
     D00304  Divalproex sodium (USP) <US>
  Lyases (EC4)
   Carboxy-lyases
    GAD
     D00304  Divalproex sodium (USP) <US>
治療薬の医薬品クラス [jp08360.html]
 神経性疾患薬
  D00304
 麻酔薬・鎮痛薬と抗炎症薬
  D00304
BRITE hierarchy
リンク   
CAS: 76584-70-8
PubChem: 7847370
ChEBI: 4667
DrugBank: DB00510
LigandBox: D00304

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