KEGG   DRUG: D00458Help
エントリ  
D00458                      Drug                                   

一般名   
クエチアピンフマル酸塩 (JP16);
Quetiapine fumarate (JP16/USAN)
商品名   
  後発品
クエチアピン (Meiji Seikaファルマ), クエチアピン (あすかActavis製薬), クエチアピン (サンド), クエチアピン (シオノケミカル), クエチアピン (テバ製薬), クエチアピン (ニプロ), クエチアピン (ニプロ), クエチアピン (ファイザー), クエチアピン (共和薬品工業), クエチアピン (大正薬品工業), クエチアピン (富士フイルムファーマ), クエチアピン (小林化工), クエチアピン (日医工), クエチアピン (日新製薬-山形), クエチアピン (日本ジェネリック), クエチアピン (東和薬品), クエチアピン (沢井製薬), クエチアピン (田辺三菱製薬), クエチアピン (田辺三菱製薬), クエチアピン (田辺三菱製薬), クエチアピン (第一三共エスファ), クエチアピン (高田製薬), クエチアピン (高田製薬)
米国の商品 
SEROQUEL (AstraZeneca Pharmaceuticals LP), SEROQUEL (AstraZeneca Pharmaceuticals LP), SEROQUEL (Bryant Ranch Prepack), SEROQUEL (Bryant Ranch Prepack), SEROQUEL (Bryant Ranch Prepack), SEROQUEL (Bryant Ranch Prepack), SEROQUEL (Bryant Ranch Prepack), SEROQUEL (Cardinal Health), SEROQUEL (Contract Pharmacy Services-PA), SEROQUEL (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), SEROQUEL (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), SEROQUEL (Lake Erie Medical DBA Quality Care Products LLC), SEROQUEL (Lake Erie Medical DBA Quality Care Products LLC), SEROQUEL (PD-Rx Pharmaceuticals), SEROQUEL (PD-Rx Pharmaceuticals), SEROQUEL (PD-Rx Pharmaceuticals), SEROQUEL (Physicians Total Care), SEROQUEL (Physicians Total Care), SEROQUEL (REMEDYREPACK), SEROQUEL (REMEDYREPACK), SEROQUEL (REMEDYREPACK), SEROQUEL (REMEDYREPACK), SEROQUEL (REMEDYREPACK), SEROQUEL (REMEDYREPACK), SEROQUEL (REMEDYREPACK), SEROQUEL (REMEDYREPACK), SEROQUEL (REMEDYREPACK), SEROQUEL (Rebel Distributors Corp), SEROQUEL (STAT RX USA LLC), SEROQUEL (TYA Pharmaceuticals), SEROQUEL (REMEDYREPACK)
  後発品
QUETIAPINE FUMARATE (Accord Healthcare), QUETIAPINE FUMARATE (Alembic Pharmaceuticals Limited), QUETIAPINE FUMARATE (American Health Packaging), QUETIAPINE FUMARATE (Aphena Pharma Solutions - Tennessee), QUETIAPINE FUMARATE (Aphena Pharma Solutions - Tennessee), QUETIAPINE FUMARATE (Apotex Corp.), QUETIAPINE FUMARATE (Ascend Laboratories), QUETIAPINE FUMARATE (Aurobindo Pharma Limited), QUETIAPINE FUMARATE (AvKARE), QUETIAPINE FUMARATE (BluePoint Laboratories), QUETIAPINE FUMARATE (Breckenridge Pharmaceutical), QUETIAPINE FUMARATE (Bryant Ranch Prepack), QUETIAPINE FUMARATE (Bryant Ranch Prepack), QUETIAPINE FUMARATE (Bryant Ranch Prepack), QUETIAPINE FUMARATE (Bryant Ranch Prepack), QUETIAPINE FUMARATE (Bryant Ranch Prepack), QUETIAPINE FUMARATE (Cardinal Health), QUETIAPINE FUMARATE (Cardinal Health), QUETIAPINE FUMARATE (Citron Pharma LLC), QUETIAPINE FUMARATE (Clinical Solutions Wholesale), QUETIAPINE FUMARATE (DIRECT RX), QUETIAPINE FUMARATE (Dr.Reddy's Laboratories Limited), QUETIAPINE FUMARATE (Golden State Medical Supply), QUETIAPINE FUMARATE (Jubilant Cadista Pharmaceuticals), QUETIAPINE FUMARATE (Lupin Pharmaceuticals), QUETIAPINE FUMARATE (Major Pharmaceuticals), QUETIAPINE FUMARATE (Major Pharmaceuticals), QUETIAPINE FUMARATE (McKesson Packaging Services a business unit of McKesson Corporation), QUETIAPINE FUMARATE (NCS HealthCare of KY), QUETIAPINE FUMARATE (NorthStar Rx LLC), QUETIAPINE FUMARATE (Physicians Total Care), QUETIAPINE FUMARATE (Preferred Pharmaceuticals), QUETIAPINE FUMARATE (Preferred Pharmaceuticals), QUETIAPINE FUMARATE (Proficient Rx LP), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (Roxane Laboratories), QUETIAPINE FUMARATE (STAT Rx USA LLC), QUETIAPINE FUMARATE (Safecor Health), QUETIAPINE FUMARATE (Sandoz), QUETIAPINE FUMARATE (Sun Pharma Global FZE), QUETIAPINE FUMARATE (TYA Pharmaceuticals), QUETIAPINE FUMARATE (TYA Pharmaceuticals), QUETIAPINE FUMARATE (TYA Pharmaceuticals), QUETIAPINE FUMARATE (Teva Pharmaceuticals USA), QUETIAPINE FUMARATE (Teva Pharmaceuticals USA), QUETIAPINE FUMARATE (Torrent Pharmaceuticals Limited), QUETIAPINE FUMARATE (Unit Dose Services)
組成式   
(C21H25N3O2S)2. C4H4O4
質量    
882.3445
分子量   
883.0864
構造式   
Mol fileKCF fileDB searchJmolKegDraw
効能    
精神神経用薬
コード   
薬効分類: 1179
ATCコード: N05AH04
医薬品グループ: DG00899
コメント  
多元受容体標的化抗精神病薬 (MARTA)
ベンゾジアゼピン系抗精神病薬
適応症: 統合失調症
ターゲット 
5-HT2A-receptor antagonist [HSA:3356] [KO:K04157];
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145];
H1-receptor antagonist [HSA:3269] [KO:K04149];
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135];
dopamine D3-receptor antagonist [HSA:1814] [KO:K04146];
dopamine D4-receptor antagonist [HSA:1815] [KO:K04147];
5-HT6-receptor antagonist [HSA:3362] [KO:K04162]
  パスウェイ
hsa04020  カルシウムシグナル伝達経路
hsa04080  神経刺激性リガンドとレセプターの相互作用
hsa04270  血管平滑筋の収縮
hsa04540  ギャップ結合
hsa04970  唾液の分泌  
 
代謝    
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
相互作用  
Drug interaction
構造マップ 
ドパミン受容体の作動薬と拮抗薬
階層分類  
医療用医薬品の薬効分類 [BR:jp08301]
 1  神経系及び感覚器官用医薬品
  11  中枢神経系用薬
   117  精神神経用剤
    1179  その他の精神神経用剤
     D00458  クエチアピンフマル酸塩 (JP16)
医療用医薬品のATC分類 [BR:jp08303]
 N 神経系
  N05 精神抑制薬
   N05A 抗精神病薬
    N05AH ジアゼピン、オクサゼピン、チアゼピン
     N05AH04 クエチアピン
      D00458  クエチアピンフマル酸塩 (JAN)
医療用医薬品のUSP分類 [BR:jp08302]
 抗うつ薬
  その他抗うつ薬
   クエチアピン
    D00458  クエチアピンフマル酸塩 (JAN)
 抗精神病薬
  第2世代/非定型
   クエチアピン
    D00458  クエチアピンフマル酸塩 (JAN)
 双極性障害治療薬
  その他双極性障害治療薬
   クエチアピン
    D00458  クエチアピンフマル酸塩 (JAN)
ターゲットに基づく医薬品分類 [BR:jp08310]
 Gタンパク質共役受容体
  ロドプシンファミリー
   アドレナリン
    α1-アドレナリン受容体
     クエチアピン
      D00458  クエチアピンフマル酸塩 (JAN)
   ドパミン
    ドパミンD2-受容体
     クエチアピン
      D00458  クエチアピンフマル酸塩 (JAN)
    ドパミンD3-受容体
     クエチアピン
      D00458  クエチアピンフマル酸塩 (JAN)
    ドパミンD4-受容体
     クエチアピン
      D00458  クエチアピンフマル酸塩 (JAN)
   ヒスタミン
    H1-受容体
     クエチアピン
      D00458  クエチアピンフマル酸塩 (JAN)
   セロトニン
    5-HT2A-受容体
     クエチアピン
      D00458  クエチアピンフマル酸塩 (JAN)
    5-HT6-受容体
     クエチアピン
      D00458  クエチアピンフマル酸塩 (JAN)
チトクローム P450 の相互作用 [BR:jp08309]
 基質
  CYP3A4
   クエチアピン
    D00458  クエチアピンフマル酸塩 (JP16)
  CYP3A5
   クエチアピン
    D00458  クエチアピンフマル酸塩 (JP16)
  CYP3A7
   クエチアピン
    D00458  クエチアピンフマル酸塩 (JP16)
日本薬局方収載医薬品 [BR:jp08311]
 化学薬品等
  D00458  クエチアピンフマル酸塩
  D00458  クエチアピンフマル酸塩細粒
  D00458  クエチアピンフマル酸塩錠
BRITE hierarchy
リンク   
CAS: 
111974-72-2
PubChem: 
DrugBank: 
LigandBox: 
日化辞: 

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