KEGG   DRUG: 塩酸メトクロプラミドHelp
エントリ  
D05008                      Drug                                   

一般名   
塩酸メトクロプラミド;
Metoclopramide hydrochloride (USAN);
Metoclopramide hydrochloride monohydrate
米国の商品 
  後発品
METOCLOPRAMIDE (A-S Medication Solutions), METOCLOPRAMIDE (ANI Pharmaceuticals), METOCLOPRAMIDE (Aidarex Pharmaceuticals LLC), METOCLOPRAMIDE (American Health Packaging), METOCLOPRAMIDE (Aphena Pharma Solutions - Tennessee), METOCLOPRAMIDE (Apotheca), METOCLOPRAMIDE (AvKARE), METOCLOPRAMIDE (Bryant Ranch Prepack), METOCLOPRAMIDE (Bryant Ranch Prepack), METOCLOPRAMIDE (Cardinal Health), METOCLOPRAMIDE (Carilion Materials Management), METOCLOPRAMIDE (Hospira), METOCLOPRAMIDE (Lake Erie Medical DBA Quality Care Products LLC), METOCLOPRAMIDE (Lake Erie Medical DBA Quality Care Products LLC), METOCLOPRAMIDE (Liberty Pharmaceuticals), METOCLOPRAMIDE (Mylan Institutional), METOCLOPRAMIDE (NCS HealthCare of KY), METOCLOPRAMIDE (NCS HealthCare of KY), METOCLOPRAMIDE (NCS HealthCare of KY), METOCLOPRAMIDE (NCS HealthCare of KY), METOCLOPRAMIDE (NuCare Pharmaceuticals), METOCLOPRAMIDE (NuCare Pharmaceuticals), METOCLOPRAMIDE (NuCare Pharmaceuticals), METOCLOPRAMIDE (NuCare Pharmaceuticals), METOCLOPRAMIDE (Par Pharmaceutical), METOCLOPRAMIDE (Physicians Total Care), METOCLOPRAMIDE (Preferred Pharmaceuticals), METOCLOPRAMIDE (Preferred Pharmaceuticals), METOCLOPRAMIDE (Proficient Rx LP), METOCLOPRAMIDE (REMEDYREPACK), METOCLOPRAMIDE (REMEDYREPACK), METOCLOPRAMIDE (REMEDYREPACK), METOCLOPRAMIDE (Ranbaxy Pharmaceuticals), METOCLOPRAMIDE (Rebel Distributors Corp.), METOCLOPRAMIDE (RedPharm Drug), METOCLOPRAMIDE (State of Florida DOH Central Pharmacy), METOCLOPRAMIDE (Teva Parenteral Medicines), METOCLOPRAMIDE (Teva Parenteral Medicines), METOCLOPRAMIDE (Teva Parenteral Medicines), METOCLOPRAMIDE (Teva Pharmaceuticals USA), METOCLOPRAMIDE (Unit Dose Services), METOCLOPRAMIDE HYDROCHLORIDE (Actavis Pharma), METOCLOPRAMIDE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), METOCLOPRAMIDE (Atlantic Biologicals Corps), METOCLOPRAMIDE (Atlantic Biologicals Corps), METOCLOPRAMIDE (Atlantic Biologicals Corps), METOCLOPRAMIDE HYDROCHLORIDE (Bryant Ranch Prepack), METOCLOPRAMIDE HYDROCHLORIDE (Bryant Ranch Prepack), METOCLOPRAMIDE HYDROCHLORIDE (Bryant Ranch Prepack), METOCLOPRAMIDE HYDROCHLORIDE (Cardinal Health), METOCLOPRAMIDE (Cardinal Health), METOCLOPRAMIDE (Cardinal Health), METOCLOPRAMIDE HYDROCHLORIDE (Cardinal Health), METOCLOPRAMIDE HYDROCHLORIDE (DIRECT RX), METOCLOPRAMIDE (Fresenius Kabi USA), METOCLOPRAMIDE (Heritage Pharmaceuticals), METOCLOPRAMIDE HYDROCHLORIDE (Impax Generics), METOCLOPRAMIDE HYDROCHLORIDE (Lupin Pharmaceuticals), METOCLOPRAMIDE HYDROCHLORIDE (Lupin Pharmaceuticals), METOCLOPRAMIDE HYDROCHLORIDE (McKesson Corporation), METOCLOPRAMIDE HYDROCHLORIDE (NCS HealthCare of KY), METOCLOPRAMIDE HYDROCHLORIDE (NCS HealthCare of KY), METOCLOPRAMIDE HYDROCHLORIDE (Novel Laboratories), METOCLOPRAMIDE HYDROCHLORIDE (NuCare Pharmaceuticals), METOCLOPRAMIDE HYDROCHLORIDE (NuCare Pharmaceuticals), METOCLOPRAMIDE HYDROCHLORIDE (NuCare Pharmaceuticals), METOCLOPRAMIDE (Pharmaceutical Associates), METOCLOPRAMIDE HYDROCHLORIDE (Preferred Pharmaceuticals), METOCLOPRAMIDE HYDROCHLORIDE (Preferred Pharmaceuticals), METOCLOPRAMIDE HYDROCHLORIDE (Rebel Distributors Corp), METOCLOPRAMIDE HYDROCHLORIDE (Rebel Distributors Corp), METOCLOPRAMIDE HYDROCHLORIDE (RedPharm Drug), METOCLOPRAMIDE HYDROCHLORIDE (RedPharm Drug), METOCLOPRAMIDE HYDROCHLORIDE (State of Florida DOH Central Pharmacy), METOCLOPRAMIDE (Unit Dose Services), METOCLOPRAMIDE HYDROCHLORIDE (VistaPharm)
組成式   
C14H22ClN3O2. HCl. H2O
質量    
353.1273
分子量   
354.2726
構造式   
Mol fileKCF fileDB searchJmolKegDraw
Simcomp    SIMCOMP
クラス   
精神神経系用薬
 DG01478  ドパミン拮抗薬
  DG01474  ドパミンD2-受容体拮抗薬
消化器系用薬
 DG01763  消化器運動改善薬
 DG01762  制吐薬
  DG01783  ベンズアミド系制吐薬
その他
 DG01489  5-HT3-受容体拮抗薬
Cyp 基質
 DG01644  CYP2D6により代謝される薬剤
Cyp 阻害
 DG01645  CYP2D6阻害薬
コード   
ATCコード: A03FA01
化学構造グループ: DG00055
商品 (DG00055): D00726<JP> D02213<JP> D05008<US>
効能    
制吐薬, 消化管運動改善薬, ドパミンD2受容体拮抗薬
コメント  
ベンズアミド誘導体
ターゲット 
DRD2 [HSA:1813] [KO:K04145]
  パスウェイ
hsa04080  神経刺激性リガンドとレセプターの相互作用
hsa04728  ドーパミン作動性シナプス
代謝    
Enzyme: CYP2D6 [HSA:1565]
相互作用  
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
構造マップ 
map07028  抗精神病薬
map07048  抗片頭痛薬
map07211  セロトニン受容体の作動薬と拮抗薬
階層分類  
医療用医薬品のATC分類 [BR:jp08303]
 A 消化管と代謝作用
  A03 機能的胃腸疾患用薬
   A03F 運動改善薬
    A03FA 運動改善薬
     A03FA01 メトクロプラミド
      D05008  塩酸メトクロプラミド <US>
医療用医薬品のUSP分類 [BR:jp08302]
 制吐薬
  その他制吐薬
   メトクロプラミド
    D05008  塩酸メトクロプラミド
 胃腸薬
  その他胃腸薬
   メトクロプラミド
    D05008  塩酸メトクロプラミド
動物用医薬品分類 [BR:jp08331]
 93  消化器官用薬
  932  整胃腸剤(止瘍、吸着、消泡剤を含む)
   9329  その他の整胃腸剤
    D05008  メトクロプラミド塩酸塩
Target-based classification of drugs  [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D05008  Metoclopramide hydrochloride (USAN) <US>
治療薬の医薬品クラス [jp08360.html]
 消化器官用薬
  D05008
BRITE hierarchy
リンク   
CAS: 54143-57-6
PubChem: 47206735
ChEBI: 6899
ChEMBL: CHEMBL1200940
DrugBank: DB01233
LigandBox: D05008
日化辞: J1.592.759C

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