KEGG   DRUG: KetoprofenHelp
Entry
D00132                      Drug                                   

Name
Ketoprofen (JP17/USP/INN);
Orudis (TN)
Product
  Generic
KETOPROFEN (A-S Medication Solutions), KETOPROFEN (A-S Medication Solutions LLC), KETOPROFEN (Aidarex Pharmaceuticals LLC), KETOPROFEN (Aidarex Pharmaceuticals LLC), KETOPROFEN (Avera McKennan Hospital), KETOPROFEN (Bryant Ranch Prepack), KETOPROFEN (Bryant Ranch Prepack), KETOPROFEN (H.J. Harkins Company), KETOPROFEN (Mylan Pharmaceuticals), KETOPROFEN (NuCare Pharmaceuticals), KETOPROFEN (PD-Rx Pharmaceuticals), KETOPROFEN (PD-Rx Pharmaceuticals), KETOPROFEN (PD-Rx Pharmaceuticals), KETOPROFEN (Physicians Total Care), KETOPROFEN (Preferred Pharmaceuticals), KETOPROFEN (Preferred Pharmaceuticals), KETOPROFEN (Proficient Rx LP), KETOPROFEN (Rebel Distributors Corp), KETOPROFEN (Rebel Distributors Corp), KETOPROFEN (RedPharm Drug), KETOPROFEN (STAT RX USA LLC), KETOPROFEN (Teva Pharmaceuticals USA)
  Other
Formula
C16H14O3
Exact mass
254.0943
Mol weight
254.2806
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01908  Antiinflammatory drug, propionic acid derivatives
 DG01504  Nonsteroidal antiinflammatory drug (NSAID)
  DG01908  Antiinflammatory drug, propionic acid derivatives
Remark
Same as: 
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor
Comment
Propionic acid derivative
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509];
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
Arachidonic acid metabolism
VEGF signaling pathway
Interaction
Transporter inhibition: OAT2 [HSA:10864]
Drug interaction
Structure map
Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AE Propionic acid derivatives
     M01AE03 Ketoprofen
      D00132  Ketoprofen (JP17/USP/INN)
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA10 Ketoprofen
      D00132  Ketoprofen (JP17/USP/INN)
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Ketoprofen
    D00132  Ketoprofen (JP17/USP/INN)
 Anti-inflammatory Agents
  Nonsteroidal Anti-inflammatory Drugs
   Ketoprofen
    D00132  Ketoprofen (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D00132  Ketoprofen (JP17/USP/INN)
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2649  Others
     D00132  Ketoprofen (JP17/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00132  Ketoprofen (JP17/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Ketoprofen
    D00132  Ketoprofen (JP17/USP/INN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Ketoprofen
    D00132  Ketoprofen (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   cyclooxygenase-1 (COX-1)
    Ketoprofen
     D00132  Ketoprofen (JP17/USP/INN)
   cyclooxygenase-2 (COX-2)
    Ketoprofen
     D00132  Ketoprofen (JP17/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Transporter inhibitors
  OAT2
   Ketoprofen
    D00132  Ketoprofen (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00132  Ketoprofen
Antirheumatic and antigout drugs [br08366.html]
 Antirheumatic drugs
  D00132
Anesthetics, analgesics and anti-inflammatory drugs [br08369.html]
 Anti-inflammatory drugs
  D00132
Rx-to-OTC switch list in the USA [br08315.html]
 D00132
Rx-to-OTC switch list in Japan [br08314.html]
 D00132
BRITE hierarchy
Other DBs
CAS: 
22071-15-4
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        19
            1   C8x C     6.4400  -15.7500
            2   C8x C     6.4400  -17.1500
            3   C8x C     7.6524  -17.8500
            4   C8x C     8.8649  -17.1500
            5   C8y C     8.8649  -15.7500
            6   C8x C     7.6524  -15.0500
            7   C8x C    11.2897  -17.1500
            8   C8y C    11.2897  -15.7500
            9   C5a C    10.0773  -15.0500
            10  C8x C    12.5022  -17.8500
            11  C8x C    13.7146  -17.1500
            12  C8y C    13.7146  -15.7500
            13  C8x C    12.5022  -15.0500
            14  O5a O    10.0773  -13.6500
            15  C1c C    14.9311  -15.0477
            16  C6a C    16.1286  -15.7392
            17  C1a C    14.9311  -13.6502
            18  O6a O    17.3149  -15.0543
            19  O6a O    16.1287  -17.1497
BOND        20
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15    9  14 2
            16   12  15 1
            17   15  16 1
            18   15  17 1
            19   16  18 1
            20   16  19 2

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