KEGG   DRUG: KetoprofenHelp
Entry
D00132                      Drug                                   

Name
Ketoprofen (JP17/USP/INN);
Orudis (TN)
Product
  Generic
Formula
C16H14O3
Exact mass
254.0943
Mol weight
254.2806
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01908  Antiinflammatory drug, propionic acid derivatives
 DG01504  Nonsteroidal antiinflammatory drug (NSAID)
  DG01908  Antiinflammatory drug, propionic acid derivatives
Remark
Same as: C01716
Therapeutic category: 1149 2649
ATC code: M01AE03 M02AA10
Chemical structure group: DG00753
Product (DG00753): D00132<JP/US>
Efficacy
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor
Comment
Propionic acid derivative
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Transporter inhibition: SLC22A7 [HSA:10864]
Drug interaction
Structure map
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AE Propionic acid derivatives
     M01AE03 Ketoprofen
      D00132  Ketoprofen (JP17/USP/INN) <JP/US>
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA10 Ketoprofen
      D00132  Ketoprofen (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Ketoprofen
    D00132  Ketoprofen (JP17/USP/INN)
 Anti-inflammatory Agents
  Nonsteroidal Anti-inflammatory Drugs
   Ketoprofen
    D00132  Ketoprofen (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D00132  Ketoprofen (JP17/USP/INN)
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2649  Others
     D00132  Ketoprofen (JP17/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00132  Ketoprofen (JP17/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Ketoprofen
    D00132  Ketoprofen (JP17/USP/INN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Ketoprofen
    D00132  Ketoprofen (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D00132  Ketoprofen (JP17/USP/INN) <JP/US>
    PTGS2 (COX2)
     D00132  Ketoprofen (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00132  Ketoprofen
Drug classes of therapeutic agents [br08360.html]
 Antirheumatic and antigout agents
  D00132
 Anesthetics, analgesics and anti-inflammatory drugs
  D00132
Rx-to-OTC switch list in the USA [br08315.html]
 D00132
Rx-to-OTC switch list in Japan [br08314.html]
 D00132
BRITE hierarchy
Other DBs
CAS: 22071-15-4
PubChem: 7847200
ChEBI: 6128
ChEMBL: CHEMBL571
DrugBank: DB01009
LigandBox: D00132
NIKKAJI: J3.468A
KCF data Show

ATOM        19
            1   C8x C     6.4400  -15.7500
            2   C8x C     6.4400  -17.1500
            3   C8x C     7.6524  -17.8500
            4   C8x C     8.8649  -17.1500
            5   C8y C     8.8649  -15.7500
            6   C8x C     7.6524  -15.0500
            7   C8x C    11.2897  -17.1500
            8   C8y C    11.2897  -15.7500
            9   C5a C    10.0773  -15.0500
            10  C8x C    12.5022  -17.8500
            11  C8x C    13.7146  -17.1500
            12  C8y C    13.7146  -15.7500
            13  C8x C    12.5022  -15.0500
            14  O5a O    10.0773  -13.6500
            15  C1c C    14.9311  -15.0477
            16  C6a C    16.1286  -15.7392
            17  C1a C    14.9311  -13.6502
            18  O6a O    17.3149  -15.0543
            19  O6a O    16.1287  -17.1497
BOND        20
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15    9  14 2
            16   12  15 1
            17   15  16 1
            18   15  17 1
            19   16  18 1
            20   16  19 2

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