KEGG   DRUG: D00132Help
Entry
D00132                      Drug                                   

Name
Ketoprofen (JP16/USP/INN);
Orudis (TN)
Product
  Generic
Formula
C16H14O3
Exact mass
254.0943
Mol weight
254.2806
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-inflammatory [DS:H00445 H00630]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Target
cyclooxygenase-1 (COX-1) inhibitor [HSA:5742] [KO:K00509];
cyclooxygenase-2 (COX-2) inhibitor [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
hsa04370  VEGF signaling pathway  
 
Interaction
Transporter inhibition: OAT2 [HSA:10864]
Drug interaction
Structure map
Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AE Propionic acid derivatives
     M01AE03 Ketoprofen
      D00132  Ketoprofen (JP16/USP/INN)
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA10 Ketoprofen
      D00132  Ketoprofen (JP16/USP/INN)
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Ketoprofen
    D00132  Ketoprofen (JP16/USP/INN)
 Anti-inflammatory Agents
  Nonsteroidal Anti-inflammatory Drugs
   Ketoprofen
    D00132  Ketoprofen (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D00132  Ketoprofen (JP16/USP/INN)
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2649  Others
     D00132  Ketoprofen (JP16/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00132  Ketoprofen (JP16/USP/INN)
  -- Analgesic and anti-inflammatory remedies (patches)
   D00132  Ketoprofen (JP16/USP/INN)
  -- Analgesic and anti-inflammatory remedies (embrocations)
   D00132  Ketoprofen (JP16/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Ketoprofen
    D00132  Ketoprofen (JP16/USP/INN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Ketoprofen
    D00132  Ketoprofen (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   cyclooxygenase-1 (COX-1)
    Ketoprofen
     D00132  Ketoprofen (JP16/USP/INN)
   cyclooxygenase-2 (COX-2)
    Ketoprofen
     D00132  Ketoprofen (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00132  Ketoprofen
BRITE hierarchy
Other DBs
CAS: 
22071-15-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        19
            1   C8x C     6.4400  -15.7500
            2   C8x C     6.4400  -17.1500
            3   C8x C     7.6524  -17.8500
            4   C8x C     8.8649  -17.1500
            5   C8y C     8.8649  -15.7500
            6   C8x C     7.6524  -15.0500
            7   C8x C    11.2897  -17.1500
            8   C8y C    11.2897  -15.7500
            9   C5a C    10.0773  -15.0500
            10  C8x C    12.5022  -17.8500
            11  C8x C    13.7146  -17.1500
            12  C8y C    13.7146  -15.7500
            13  C8x C    12.5022  -15.0500
            14  O5a O    10.0773  -13.6500
            15  C1c C    14.9311  -15.0477
            16  C6a C    16.1286  -15.7392
            17  C1a C    14.9311  -13.6502
            18  O6a O    17.3149  -15.0543
            19  O6a O    16.1287  -17.1497
BOND        20
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15    9  14 2
            16   12  15 1
            17   15  16 1
            18   15  17 1
            19   16  18 1
            20   16  19 2

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