KEGG   DRUG: D00140Help
Entry
D00140                      Drug                                   

Name
Erythromycin (JP16/USP/INN);
EM;
Akne-mycin (TN);
Eryc (TN);
Erygel (TN);
Pce (TN);
Staticin (TN);
T-stat (TN)
Product
  Generic
ERYTHROMYCIN (A-S Medication Solutions LLC), ERY-TAB (A-S Medication Solutions LLC), ERYTHROMYCIN (A-S Medication Solutions LLC), ERYTHROMYCIN (A-S Medication Solutions LLC), ERYTHROMYCIN (Aidarex Pharmaceuticals LLC), ERYTHROMYCIN (Akorn), ERYTHROMYCIN (Akorn), ERYTHROMYCIN (Arbor Pharmaceuticals), ERYTHROMYCIN (Arbor Pharmaceuticals), ERY-TAB (Arbor Pharmaceuticals), ERYTHROMYCIN (Bausch & Lomb Incorporated), ERYTHROMYCIN BASE FILMTAB (Cardinal Health), ERYTHROMYCIN (Cardinal Health), ERYTHROMYCIN (Cardinal Health), ERY-TAB (Carilion Materials Management), ERY-TAB (Carilion Materials Management), ERYTHROMYCIN (Carilion Materials Management), ERYTHROMYCIN (Direct Rx), ERYTHROMYCIN (Dispensing Solutions), ERYTHROMYCIN (E. FOUGERA &), ERYTHROMYCIN (E. Fougera & Co. a division of Fougera Pharmaceuticals), ERYTHROMYCIN (Fera Pharmaceuticals), ILOTYCIN (Fera Pharmaceuticals), ERYTHROMYCIN (H.J. Harkins Company), ERYTHROMYCIN (KAISER FOUNDATION HOSPITALS), ERY-TAB (KAISER FOUNDATION HOSPITALS), ERYTHROMYCIN (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), ERYTHROMYCIN BASE FILMTAB (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), ERYTHROMYCIN (Lake Erie Medical DBA Quality Care Products LLC), ERYTHROMYCIN (Midlothian Laboratories), ERYTHROMYCIN (Morton Grove Pharmaceuticals), ERY-TAB (PD-Rx Pharmaceuticals), ERY-TAB (PD-Rx Pharmaceuticals), ERYTHROMYCIN BASE (PD-Rx Pharmaceuticals), ERYTHROMYCIN BASE (PD-Rx Pharmaceuticals), ERYTHRA-DERM (Paddock Laboratories), ERYTHROMYCIN (Paddock Laboratories), ILOTYCIN (Paddock Laboratories), ERYTHROMYCIN (Perrigo New York), ERY (Perrigo New York), ERYTHROMYCIN (Perrigo New York), ERYTHROMYCIN (Physicians Total Care), ERY-TAB (Physicians Total Care), ERYTHROMYCIN (Physicians Total Care), ERYTHROMYCIN (Physicians Total Care), ERYTHROMYCIN (Preferred Pharmaceuticals), ERYTHROMYCIN (Preferred Pharmaceuticals), ERYTHROMYCIN (Preferred Pharmaceuticals), ERYGEL (Prestium Pharma), ERYTHROMYCIN BASE (REMEDYREPACK), ERYTHROMYCIN BASE (REMEDYREPACK), ERY-TAB (REMEDYREPACK), ERYTHROMYCIN (REMEDYREPACK), ERYTHROMYCIN BASE (REMEDYREPACK), ERYTHROMYCIN (REMEDYREPACK), ERY-TAB (REMEDYREPACK), ERYTHROMYCIN (Rebel Distributors Corp), ERY-TAB (Rebel Distributors Corp), ERYTHROMYCIN BASE FILMTAB (Rebel Distributors Corp), ERYTHROMYCIN (STAT RX USA LLC), ERY-TAB (STAT Rx USA LLC), ERY-TAB (STAT Rx USA LLC), ERYTHROMYCIN (Stat Rx USA), ERYTHROMYCIN (Stat Rx USA), ERYTHROMYCIN (VersaPharm Incorporated)
Formula
C37H67NO13
Exact mass
733.4612
Mol weight
733.9268
Structure
Mol fileKCF fileDB searchJmolKegDraw
Sequence
0 Pyk  1 Mtk  2 Mtn  3 Mte  4 Mtk  5 Mtk  6 Mtn
  Type
PK
Source
Saccharopolyspora erythraea [TAX:1836]
Activity
Antibacterial
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Natural product
Target
23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor [KO:K01980]
  Pathway
ko03010  Ribosome  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A7 [HSA:1551]
Transporter: OAT2 [HSA:10864]
Interaction
CYP inhibition: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551], CYP2C19 [HSA:1557]
Transporter inhibition: ABCB1 [HSA:5243], SLCO1B1 [HSA:10599]
Drug interaction
Structure map
Macrolides and ketolides
Other map
Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF02 Erythromycin
      D00140  Erythromycin (JP16/USP/INN)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA01 Erythromycin
      D00140  Erythromycin (JP16/USP/INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA17 Erythromycin
      D00140  Erythromycin (JP16/USP/INN)
USP drug classification [BR:br08302]
 Antibacterials
  Macrolides
   Erythromycin
    D00140  Erythromycin (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   614  Acting mainly on gram-positive bacteria and mycoplasma
    6141  Erythromycins
     D00140  Erythromycin (JP16/USP/INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   23S rRNA of 50S ribosomal subunit inhibitor
    Macrolides
     Erythromycin
      D00140  Erythromycin (JP16/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Erythromycin
    D00140  Erythromycin (JP16/USP/INN)
  CYP3A5
   Erythromycin
    D00140  Erythromycin (JP16/USP/INN)
  CYP3A7
   Erythromycin
    D00140  Erythromycin (JP16/USP/INN)
 Inhbitors
  CYP2C19
   Erythromycin
    D00140  Erythromycin (JP16/USP/INN)
  CYP3A4
   Erythromycin
    D00140  Erythromycin (JP16/USP/INN)
  CYP3A7
   Erythromycin
    D00140  Erythromycin (JP16/USP/INN)
  CYP3A
   Erythromycin
    D00140  Erythromycin (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00140  Erythromycin
  D00140  Erythromycin enteric-coated tablets
BRITE hierarchy
Other DBs
CAS: 
114-07-8
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        51
            1   C1y C    29.5344  -13.7288
            2   C1z C    29.5344  -12.3594
            3   C1y C    28.3449  -14.4078
            4   O2a O    31.5246  -14.4484
            5   C1x C    28.3449  -11.6747
            6   O1a O    30.5672  -11.3672
            7   C1a C    30.8225  -12.7945
            8   C1y C    28.3449  -15.7772
            9   C1a C    27.3697  -13.3814
            10  C1y C    33.1096  -13.7303
            11  C1y C    28.3449  -10.2995
            12  O2a O    29.0876  -17.1408
            13  C1y C    27.1669  -16.4620
            14  C1y C    34.2830  -14.4247
            15  O2x O    33.1216  -12.3614
            16  C5x C    27.1669   -9.6205
            17  C1a C    29.5344   -9.6205
            18  C1y C    30.6105  -17.5606
            19  C7x C    25.9774  -15.7772
            20  C1a C    27.1669  -17.8312
            21  C1y C    35.4739  -13.7601
            22  O1a O    34.2739  -15.7986
            23  C1y C    34.3175  -11.6941
            24  C1y C    25.9774  -10.2995
            25  O5x O    27.1669   -8.2511
            26  C1x C    30.6105  -18.9243
            27  O2x O    31.8001  -16.8760
            28  O7x O    25.9774  -14.4078
            29  O6a O    24.9155  -16.7288
            30  C1x C    35.4884  -12.3963
            31  N1c N    36.6522  -14.4516
            32  C1a C    34.3373  -10.3274
            33  C1y C    25.9774  -11.6747
            34  C1a C    24.7937   -9.6205
            35  C1z C    31.8001  -19.6148
            36  C1y C    32.9779  -17.5606
            37  C1y C    24.7937  -13.7288
            38  C1z C    24.7937  -12.3594
            39  O1a O    27.1669  -12.3594
            40  C1y C    32.9779  -18.9243
            41  O2a O    31.8001  -20.9437
            42  C1a C    33.2507  -20.6013
            43  C1a C    34.1675  -16.8818
            44  C1b C    23.6099  -14.4078
            45  C1a C    23.5404  -12.9279
            46  O1a O    23.5404  -11.6690
            47  O1a O    34.1675  -19.6148
            48  C1a C    32.9026  -21.9069
            49  C1a C    23.5747  -15.5334
            50  C1a C    37.9042  -13.7409
            51  C1a C    36.7130  -15.8195
BOND        53
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     2   6 1 #Up
            6     2   7 1 #Down
            7     3   8 1
            8     3   9 1 #Down
            9    10   4 1 #Down
            10    5  11 1
            11    8  12 1 #Down
            12    8  13 1
            13   10  14 1
            14   10  15 1
            15   11  16 1
            16   11  17 1 #Down
            17   18  12 1 #Down
            18   13  19 1
            19   13  20 1 #Up
            20   14  21 1
            21   14  22 1 #Up
            22   15  23 1
            23   16  24 1
            24   16  25 2
            25   18  26 1
            26   18  27 1
            27   19  28 1
            28   19  29 2
            29   21  30 1
            30   21  31 1 #Down
            31   23  32 1 #Down
            32   24  33 1
            33   24  34 1 #Up
            34   26  35 1
            35   27  36 1
            36   28  37 1
            37   33  38 1
            38   33  39 1 #Up
            39   35  40 1
            40   35  41 1 #Down
            41   35  42 1
            42   36  43 1 #Up
            43   37  44 1 #Down
            44   38  45 1 #Down
            45   38  46 1 #Up
            46   40  47 1 #Down
            47   41  48 1
            48   44  49 1
            49   23  30 1
            50   36  40 1
            51   37  38 1
            52   31  50 1
            53   31  51 1

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