KEGG   DRUG: D00248Help
Entry
D00248                      Drug                                   

Name
Busulfan (JP16/USP/INN);
Myleran (TN)
Product
Formula
C6H14O6S2
Exact mass
246.0232
Mol weight
246.3018
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antineoplastic [DS:H00004 H00012 H00035]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
alkylating agent
Busulfan is clearly less effective in patients with chronic myelogenous leukemia who lack the Philadelphia (Ph1) chromosome.
Target
DNA
Interaction
Genomic biomarker: BCR-ABL [HSA:613 25]
Drug interaction
Structure map
Antineoplastics - alkylating agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01A ALKYLATING AGENTS
    L01AB Alkyl sulfonates
     L01AB01 Busulfan
      D00248  Busulfan (JP16/USP/INN)
USP drug classification [BR:br08302]
 Antineoplastics
  Alkylating Agents
   Busulfan
    D00248  Busulfan (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   421  Alkylating agents
    4213  Sulfonate esters
     D00248  Busulfan (JP16/USP/INN)
Antineoplastics [BR:br08308]
 Alkylating agents
  Alkyl sulfonates
   Busulfan
    D00248  Busulfan (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00248  Busulfan
BRITE hierarchy
Other DBs
CAS: 
55-98-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        14
            1   S4a S    16.2149  -21.9100
            2   O2a O    17.4273  -22.6100
            3   C1b C    18.6397  -21.9100
            4   C1b C    19.8522  -22.6100
            5   C1b C    21.0646  -21.9100
            6   C1b C    22.2770  -22.6100
            7   O2a O    23.4895  -21.9100
            8   S4a S    24.7019  -22.6100
            9   C1a C    15.0024  -21.2100
            10  O3c O    16.9209  -20.6867
            11  O3c O    15.5214  -23.1115
            12  C1a C    25.9144  -23.3100
            13  O3c O    25.4243  -21.4059
            14  O3c O    23.9838  -23.8069
BOND        13
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     6   7 1
            7     7   8 1
            8     1   9 1
            9     1  10 2
            10    1  11 2
            11    8  12 1
            12    8  13 2
            13    8  14 2

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