KEGG   DRUG: D00334Help
Entry
D00334                      Drug                                   

Name
Gemfibrozil (JAN/USP/INN);
Lopid (TN)
Product
  Generic
GEMFIBROZIL (A-S Medication Solutions LLC), GEMFIBROZIL (Aidarex Pharmaceuticals LLC), GEMFIBROZIL (American Health Packaging), GEMFIBROZIL (Aphena Pharma Solutions - Tennessee), GEMFIBROZIL (Aphena Pharma Solutions - Tennessee), GEMFIBROZIL (Apotex Corp.), GEMFIBROZIL (AvPAK), GEMFIBROZIL (Blu Pharmaceuticals), GEMFIBROZIL (Blu Pharmaceuticals), GEMFIBROZIL (Bryant Ranch Prepack), GEMFIBROZIL (Camber Pharmaceuticals), GEMFIBROZIL (Caraco Pharmaceutical Laboratories), GEMFIBROZIL (Cardinal Health), GEMFIBROZIL (Cardinal Health), GEMFIBROZIL (Clinical Solutions Wholesale), GEMFIBROZIL (Contract Pharmacy Services-PA), GEMFIBROZIL (Contract Pharmacy Services-PA), GEMFIBROZIL (DAVA Pharmaceuticals), GEMFIBROZIL (Dispensing Solutions), GEMFIBROZIL (Exelan Pharmaceuticals), GEMFIBROZIL (Global Pharmaceuticals), GEMFIBROZIL (Golden State Medical Supply), GEMFIBROZIL (Golden State Medical Supply), GEMFIBROZIL (Hikma Pharmaceutical), GEMFIBROZIL (KAISER FOUNDATION HOSPITALS), GEMFIBROZIL (KAISER FOUNDATION HOSPITALS), GEMFIBROZIL (Major Pharmaceuticals), GEMFIBROZIL (Major Pharmaceuticals), GEMFIBROZIL (McKesson Contract Packaging), GEMFIBROZIL (Med-Health Pharma), GEMFIBROZIL (NCS HealthCare of KY), GEMFIBROZIL (Northstar RxLLC), GEMFIBROZIL (PD-Rx Pharmaceuticals), GEMFIBROZIL (Physicians Total Care), GEMFIBROZIL (Preferred Pharmaceuticals), GEMFIBROZIL (Proficient Rx LP), GEMFIBROZIL (REMEDYREPACK), GEMFIBROZIL (REMEDYREPACK), GEMFIBROZIL (REMEDYREPACK), GEMFIBROZIL (REMEDYREPACK), GEMFIBROZIL (REMEDYREPACK), GEMFIBROZIL (Rebel Distributors Corp), GEMFIBROZIL (St Marys Medical Park Pharmacy), GEMFIBROZIL (State of Florida DOH Central Pharmacy), GEMFIBROZIL (State of Florida DOH Central Pharmacy), GEMFIBROZIL (State of Florida DOH Central Pharmacy), GEMFIBROZIL (State of Florida DOH Central Pharmacy), GEMFIBROZIL (State of Florida DOH Central Pharmacy), GEMFIBROZIL (Teva Pharmaceuticals USA), GEMFIBROZIL (UDL Laboratories), GEMFIBROZIL (Unit Dose Services), GEMFIBROZIL (West-ward Pharmaceutical Corp), GEMFIBROZIL (West-ward Pharmaceutical Corp)
Formula
C15H22O3
Exact mass
250.1569
Mol weight
250.3334
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihyperlipidemic
Remark
Same as: 
ATC code: 
Drug group: 
Target
peroxisome proliferator-activated receptor (PPAR) alpha agonist [HSA:5465] [KO:K07294]
  Pathway
hsa03320  PPAR signaling pathway
hsa04920  Adipocytokine signaling pathway  
 
Interaction
CYP inhibition: CYP2C8 [HSA:1558]
Transporter inhibition: SLCO1B1 [HSA:10599]
Drug interaction
Structure map
Peroxisome proliferator-activated receptor (PPAR) agonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AB Fibrates
     C10AB04 Gemfibrozil
      D00334  Gemfibrozil (JAN/USP/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Dyslipidemics, Fibric Acid Derivatives
   Gemfibrozil
    D00334  Gemfibrozil (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Peroxisome proliferator-activated receptor (PPAR)
    peroxisome proliferator-activated receptor (PPAR) alpha
     Gemfibrozil
      D00334  Gemfibrozil (JAN/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Inhbitors
  CYP2C8
   Gemfibrozil
    D00334  Gemfibrozil (JAN/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
25812-30-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        18
            1   C8x C     9.4500  -21.2100
            2   C8x C     9.4500  -22.6100
            3   C8y C    10.6624  -23.3100
            4   C8y C    11.8749  -22.6100
            5   C8x C    11.8749  -21.2100
            6   C8y C    10.6624  -20.5100
            7   C1a C    10.6624  -19.1102
            8   C1a C    10.6624  -24.7098
            9   O2a O    13.1060  -23.3210
            10  C1b C    14.3112  -22.6253
            11  C1b C    15.4935  -23.3081
            12  C1b C    16.6875  -22.6188
            13  C1d C    17.8754  -23.3048
            14  C6a C    19.0665  -22.6171
            15  O6a O    20.2559  -23.3039
            16  O6a O    19.0667  -21.2103
            17  C1a C    17.1178  -24.5033
            18  C1a C    18.5957  -24.4949
BOND        18
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     3   8 1
            9     4   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16   14  16 2
            17   13  17 1
            18   13  18 1

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