KEGG   DRUG: D00407Help
Entry
D00407                      Drug                                   

Name
Methylprednisolone (JP16/USP/INN);
Medrol (TN)
Product
  Generic
METHYLPREDNISOLONE (A-S Medication Solutions LLC), METHYLPREDNISOLONE (Aidarex Pharmaceuticals LLC), METHYLPREDNISOLONE (American Health Packaging), METHYLPREDNISOLONE (BluePoint Laboratories), METHYLPREDNISOLONE (Breckenridge Pharmaceutical), METHYLPREDNISOLONE (Bryant Ranch Prepack), METHYLPREDNISOLONE (Clinical Solutions Wholesale), METHYLPREDNISOLONE (Dispensing Solutions), METHYLPREDNISOLONE (Greenstone LLC), METHYLPREDNISOLONE (JUBILANT CADISTA PHARMACEUTICALS), METHYLPREDNISOLONE (KAISER FOUNDATION HOSPITALS), METHYLPREDNISOLONE (Lake Erie Medical DBA Quality Care Products LLC), METHYLPREDNISOLONE (Physicians Total Care), METHYLPREDNISOLONE (Physicians Total Care), METHYLPREDNISOLONE (Preferred Pharmaceuticals), METHYLPREDNISOLONE (Qualitest Pharmaceuticals), METHYLPREDNISOLONE (REMEDYREPACK), METHYLPREDNISOLONE (REMEDYREPACK), METHYLPREDNISOLONE (REMEDYREPACK), METHYLPREDNISOLONE (Rebel Distributors Corp.), METHYLPREDNISOLONE (STAT Rx USA LLC), METHYLPREDNISOLONE (STAT Rx USA LLC), METHYLPREDNISOLONE (Sandoz), METHYLPREDNISOLONE (Unit Dose Services)
Formula
C22H30O5
Exact mass
374.2093
Mol weight
374.4706
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Glucocorticoid [DS:H00080]
Remark
Therapeutic category: 
ATC code: 
Target
glucocorticoid receptor agonist [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Glucocorticoid and meneralocorticoid receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2456  Prednisolones
     D00407  Methylprednisolone (JP16/USP/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA01 Methylprednisolone
      D00407  Methylprednisolone (JP16/USP/INN)
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA02 Methylprednisolone
      D00407  Methylprednisolone (JP16/USP/INN)
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB04 Methylprednisolone
      D00407  Methylprednisolone (JP16/USP/INN)
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Methylprednisolone
   D00407  Methylprednisolone (JP16/USP/INN)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Methylprednisolone
    D00407  Methylprednisolone (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    glucocorticoid receptor [HSA:2908] [KO:K05771]
     Methylprednisolone [ATC:D07AA01 D10AA02 H02AB04]
      D00407  Methylprednisolone (JP16/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
83-43-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        27
            1   C2x C    26.6700  -18.6900
            2   C5x C    26.6700  -20.0900
            3   C2x C    27.8600  -20.7900
            4   C2y C    29.1200  -20.0900
            5   C1z C    29.1200  -18.6900
            6   C2x C    27.8600  -17.9900
            7   C1y C    30.3100  -20.7900
            8   C1x C    31.5000  -20.0900
            9   C1y C    31.5000  -18.6900
            10  C1y C    30.3100  -17.9900
            11  C1y C    32.7600  -17.9900
            12  C1z C    32.7600  -16.5900
            13  C1x C    31.5000  -15.8900
            14  C1y C    30.3100  -16.5900
            15  C1x C    35.1400  -17.9900
            16  C1x C    35.1400  -16.5900
            17  C1z C    33.9500  -15.8900
            18  O5x O    25.4800  -20.7900
            19  C1a C    29.1200  -17.2900
            20  O1a O    29.1200  -15.8900
            21  C1a C    32.7600  -15.1900
            22  C5a C    33.9500  -14.2100
            23  C1a C    30.3100  -22.1900
            24  O1a O    35.1400  -15.1900
            25  C1b C    35.1400  -13.5100
            26  O5a O    32.7600  -13.5100
            27  O1a O    36.3300  -14.2100
BOND        30
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   14  20 1 #Up
            24   12  21 1 #Up
            25   17  22 1 #Up
            26    7  23 1 #Down
            27   17  24 1 #Down
            28   22  25 1
            29   22  26 2
            30   25  27 1

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