KEGG   DRUG: D00769Help
Entry
D00769                      Drug                                   

Name
Clopidogrel sulfate (JP16);
Clopidogrel bisulfate (USAN);
Clopidogrel sulfate tablets (JP16);
Isocover (TN);
Plavix (TN)
Product
  Generic
CLOPIDOGREL (American Health Packaging), CLOPIDOGREL (Amneal Pharmaceuticals of New York), CLOPIDOGREL (Bryant Ranch Prepack), CLOPIDOGREL BISULFATE (Cardinal Health), CLOPIDOGREL BISULFATE (Cardinal Health), CLOPIDOGREL (International Labs), CLOPIDOGREL (Legacy Pharmaceutical Packaging), CLOPIDOGREL (Legacy Pharmaceutical Packaging), CLOPIDOGREL (Macleods Pharmaceuticals Limited), CLOPIDOGREL (MedVantx), CLOPIDOGREL BISULFATE (Mylan Institutional), CLOPIDOGREL BISULFATE (Mylan Pharmaceuticals), CLOPIDOGREL BISULFATE (REMEDYREPACK), CLOPIDOGREL (St Marys Medical Park Pharmacy), CLOPIDOGREL (Teva Pharmaceuticals USA), CLOPIDOGREL (Wockhardt Limited), CLOPIDOGREL (Wockhardt USA LLC.), CLOPIDOGREL (Aidarex Pharmaceuticals LLC), CLOPIDOGREL (American Health Packaging), CLOPIDOGREL (American Health Packaging), CLOPIDOGREL (Apotex Corp.), CLOPIDOGREL (Aurobindo Pharma Limited), CLOPIDOGREL BISULFATE (Blenheim Pharmacal), CLOPIDOGREL BISULFATE (Cardinal Health), CLOPIDOGREL BISULFATE (Cardinal Health), CLOPIDOGREL BISULFATE (Dr.Reddy's Laboratories Limited), CLOPIDOGREL BISULFATE (Dr.Reddy's Laboratories Limited), CLOPIDOGREL BISULFATE (Golden State Medical Supply), CLOPIDOGREL BISULFATE (Major Pharmaceuticals), CLOPIDOGREL BISULFATE (PD-Rx Pharmaceuticals), CLOPIDOGREL BISULFATE (Physicians Total Care), CLOPIDOGREL BISULFATE (Preferred Pharmaceuticals), CLOPIDOGREL BISULFATE (REMEDYREPACK), CLOPIDOGREL BISULFATE (REMEDYREPACK), CLOPIDOGREL (REMEDYREPACK), CLOPIDOGREL BISULFATE (REMEDYREPACK), CLOPIDOGREL (REMEDYREPACK), CLOPIDOGREL BISULFATE (REMEDYREPACK), CLOPIDOGREL BISULFATE (REMEDYREPACK), CLOPIDOGREL (ReadyMeds), CLOPIDOGREL BISULFATE (State of Florida DOH Central Pharmacy), CLOPIDOGREL (State of Florida DOH Central Pharmacy), CLOPIDOGREL BISULFATE (Sun Pharma Global FZE), CLOPIDOGREL BISULFATE (Torrent Pharmaceuticals Limited), CLOPIDOGREL (Unit Dose Services), CLOPIDOGREL (Accord Healthcare)
Formula
C16H16ClNO2S. H2SO4
Exact mass
419.0264
Mol weight
419.9002
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Inhibitor [platelet]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
CYP2C19 poor metabolizer status is associated with diminished response to Clopidogrel.
Target
P2Y12 receptor antagonist [HSA:64805] [KO:K04298]
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP1A2 [HSA:1544], CYP2C19 [HSA:1557], CYP2B6 [HSA:1555]
Interaction
Genomic biomarker: CYP2C19 [HSA:1557]
CYP inhibition: CYP2B6 [HSA:1555]
Drug interaction
Structure map
Antithrombosis agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AC Platelet aggregation inhibitors excl. heparin
     B01AC04 Clopidogrel
      D00769  Clopidogrel sulfate (JAN); Clopidogrel bisulfate (USAN)
USP drug classification [BR:br08302]
 Blood Products/Modifiers/Volume Expanders
  Platelet Modifying Agents
   Clopidogrel
    D00769  Clopidogrel sulfate (JAN); Clopidogrel bisulfate (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   339  Miscellaneous
    3399  Others
     D00769  Clopidogrel sulfate (JP16); Clopidogrel bisulfate (USAN); Clopidogrel sulfate tablets (JP16)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Purine / pyrimidine
    P2Y12 receptor
     Clopidogrel
      D00769  Clopidogrel sulfate (JAN); Clopidogrel bisulfate (USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Clopidogrel
    D00769  Clopidogrel sulfate (JAN); Clopidogrel bisulfate (USAN)
  CYP2B6
   Clopidogrel
    D00769  Clopidogrel sulfate (JAN); Clopidogrel bisulfate (USAN)
  CYP2C19
   Clopidogrel
    D00769  Clopidogrel sulfate (JAN); Clopidogrel bisulfate (USAN)
  CYP3A4
   Clopidogrel
    D00769  Clopidogrel sulfate (JAN); Clopidogrel bisulfate (USAN)
 Inhbitors
  CYP2B6
   Clopidogrel
    D00769  Clopidogrel sulfate (JAN); Clopidogrel bisulfate (USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00769  Clopidogrel sulfate
  D00769  Clopidogrel sulfate tablets
BRITE hierarchy
Other DBs
CAS: 
120202-66-6
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        26
            1   N1y N    21.9223  -14.0768
            2   C1c C    20.7116  -14.7786
            3   C1x C    23.1271  -14.7786
            4   C1x C    21.9164  -12.6791
            5   C8y C    19.5011  -14.0768
            6   C7a C    20.7116  -16.1766
            7   C8y C    24.3378  -14.0827
            8   C1x C    23.1271  -11.9773
            9   C8y C    19.5011  -12.6791
            10  C8x C    18.2904  -14.7786
            11  O7a O    19.5011  -16.8782
            12  O6a O    21.9223  -16.8725
            13  C8y C    24.3378  -12.6791
            14  C8x C    25.6771  -14.5154
            15  C8x C    18.2904  -11.9773
            16  X   Cl   20.7116  -11.9773
            17  C8x C    17.0797  -14.0768
            18  C1a C    18.2904  -16.1766
            19  S2x S    25.6712  -12.2405
            20  C8x C    26.5018  -13.3751
            21  C8x C    17.0797  -12.6791
            22  S4a S    29.6520  -14.3900
            23  O1d O    29.6520  -12.9900
            24  O1d O    29.6520  -15.7900
            25  O1d O    28.2519  -14.3900
            26  O1d O    31.0519  -14.3900
BOND        27
            1     2   5 1
            2     2   6 1 #Down
            3     3   7 1
            4     4   8 1
            5     5   9 1
            6     5  10 2
            7     6  11 1
            8     6  12 2
            9     7  13 2
            10    7  14 1
            11    9  15 2
            12    9  16 1
            13   10  17 1
            14   11  18 1
            15   13  19 1
            16   14  20 2
            17   15  21 1
            18    8  13 1
            19   17  21 2
            20   19  20 1
            21    1   2 1
            22    1   3 1
            23    1   4 1
            24   22  23 2
            25   22  24 2
            26   22  25 1
            27   22  26 1

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