| Entry |
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| Name |
Gliclazide (JP16/INN);
Glimicron (TN)
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| Formula |
C15H21N3O3S
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| Exact mass |
323.1304
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| Mol weight |
323.4105
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| Structure |
     |
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| Activity |
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| Remark |
Therapeutic category: ATC code: |
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| Comment |
The effects of the sulfonylureas are initiated by binding to and blocking an ATP-sensitive K+ channel, which has been cloned.
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| Target |
sulfonylurea receptor 1 agonist [HSA: 6833] [KO: K05032] |
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| Pathway |
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| Interaction |
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| Structure map |
| Sulfonamide derivatives - hypoglycemic agents |
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
3 Agents affecting metabolism
39 Other agents affecting metabolism
396 Antidiabetic agents
3961 Sulfonylureas
D01599 Gliclazide (JP16/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A10 DRUGS USED IN DIABETES
A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
A10BB Sulfonamides, urea derivatives
A10BB09 Gliclazide
D01599 Gliclazide (JP16/INN)
Target-based classification of drugs [BR:br08310]
Transporters
ABC transporters
ABCC (CFTR/MRP) subfamily
ABCC8 (sulfonylurea receptor 1) [HSA:6833] [KO:K05032]
Gliclazide [ATC:A10BB09]
D01599 Gliclazide (JP16/INN)
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| Other DBs |
CAS: 21187-98-4 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 22
1 S4a S 33.2747 -15.6715
2 C8y C 34.4380 -16.3579
3 N1b N 31.7621 -16.4102
4 O3c O 32.4719 -14.4847
5 O3c O 34.2578 -14.4265
6 C8x C 35.6364 -15.6832
7 C8x C 34.4380 -17.6898
8 C5a C 30.6222 -15.6948
9 C8x C 36.8114 -16.3520
10 C8x C 35.6132 -18.3880
11 N1b N 29.4296 -16.3287
12 C8y C 36.8114 -17.7074
13 C1a C 37.9923 -18.3880
14 N1y N 28.2494 -15.5910
15 C1x C 28.2488 -14.1937
16 C1x C 26.9257 -16.0160
17 C1y C 26.1076 -14.8904
18 C1y C 26.9249 -13.7579
19 C1x C 26.1004 -12.6304
20 C1x C 24.7737 -13.0663
21 C1x C 24.7779 -14.4629
22 O5a O 30.6084 -14.3147
BOND 24
1 6 9 2
2 7 10 1
3 8 11 1
4 9 12 1
5 12 13 1
6 10 12 2
7 11 14 1
8 1 2 1
9 1 3 1
10 14 15 1
11 15 18 1
12 17 16 1
13 16 14 1
14 1 4 2
15 1 5 2
16 2 6 1
17 2 7 2
18 3 8 1
19 17 18 1
20 18 19 1
21 19 20 1
22 20 21 1
23 21 17 1
24 8 22 2
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